High quality medical services for marginalized groups in Cairo and the region.

Mersal Foundation for Charity and Development is a non-profit organization that serves in the health field and works on providing all types of healthcare with high quality to whoever is in need.

**Vision**
To be the number one medical organization in Egypt and the Arab region and proactive in ensuring the right in healthcare for the marginalized groups and those who are in need the most.

**Message**
Working on analyzing and filling the gaps of the healthcare system to provide high quality medical services on the basis of equality and dignity through enabling a charitable healthcare system for whoever cannot afford it, as well as contributing to the development of the health sector.

**Objectives**  

- Providing medical services to whoever deserves them regardless the cost or for how long they will be needed.
- Spreading medical awareness in all the places it serves in.
- Achieving sustainability in funding its activities Core Values.
- Privacy: Mersal ensures the patient's eligibility to receive its services without hurting their dignity or exposing them to any kind of embarrassment.
- Healthcare With No Discrimination: Mersal is an open arm to all patients with no discrimination whatsover; whatever religion, nationality, color, or language, all patients in need are welcomed to receive the organization services.
- High Quality: Mersal provides all types of medical services in the highest possible quality through its network of specialized medical personnel.
- Credibility and Transparency: Mersal announces the size and sources of its fund as well as its administrative and medical expenditures, The foundation financial reports and annual budgets are available through several outlets through which any person can explore how resources are managed. Mersal believes in the importance of being specialized in specific fields and its early choice was the healthcare services.

In the past six years, the organization registered over 25,000 patients from 27 provinces.  Mersal has been seeking to enable access to its services all over the country. And the dream of helping those who are in need whoever they are and whatever the cost and time is still alive, Mersal has worked over the past six years on getting close to its patients throughout their treatment journey.

Mersal Foundation for Charity and Development 

The Rapid Response Fund will fill critical time-sensitive funding gaps created by the suspension of US foreign aid.

The U.S. government's cuts to foreign aid have created an urgent crisis — high-impact, evidence-based programs in global health, extreme poverty, and humanitarian aid are suddenly at risk. Organizations delivering lifesaving interventions now face unexpected shortfalls that could cost lives. We can’t afford to let that happen.

Times of crisis require swift and decisive action. That’s why The Life You Can Save and Founders Pledge have jointly launched the Rapid Response Fund — a fast, strategic way to bridge gaps in funding and keep the most effective programs running at full capacity open for donations from all who care about the impact of this crisis.

We’ve already done the hard work of identifying and supporting the most cost-effective interventions in global health & development. Our recommended partners are among the best in the world at turning dollars into impact, but they now face an unprecedented funding crunch.

This fund will provide urgent bridge support and sustain essential services for our current recommended funding opportunities while also allowing us the agility to seize new high-impact opportunities as they arise in this rapidly shifting landscape. Every dollar you donate goes where it’s needed most — help us act now before it’s too late.

Founders Pledge & The Life You Can Save: Rapid Response Fund

LifeStraw operates the Safe Water Fund, a 501(c)3 project to support the provision of safe water where it is needed most.  

In addition to our retail-funded Give back program, LifeStraw's Safe Water Fund supports provision of safe water during humanitarian emergencies and natural disasters. We also utilize funds to support the implementation of long-term, sustainable safe water programs around the world. We work with incredible grassroots organizations and local partners to help identify and reach communities and families most in need. LifeStraw also implements special initiatives in the cities where our employees live, including our headquarters in Baltimore City – as well as on Giving Tuesday each year.

Your contribution helps us reach more families with safe drinking water!

**100% of donated funds go toward the cost of products and distribution of supplies. Vestergaard Frandsen, Inc. (d/b/a “LifeStraw”) does not profit from your donation.**

*LifeStraw’s Safe Water Fund operates through a fiscal sponsorship with Players Philanthropy Fund, a Texas nonprofit corporation recognized by the IRS as a tax-exempt public charity under Section 501(c)(3) of the Internal Revenue Code (Federal Tax ID: 27-6601178, ppf.org/pp). Contributions to LifeStraw’s Safe Water Fund qualify as tax-deductible.*

LifeStraw Safe Water Fund

Our School's global impact would not be possible without the crucial support of our community of committed donors and friends. 

The London School of Hygiene & Tropical Medicine (LSHTM) is renowned for its world-leading research, postgraduate studies and continuing education in public and global health.

With your help, we can increase the number of scholarships we are able to offer. We receive thousands of applications every year, with funding only available to support a small number. 

Our diverse student body is what makes our community so special. Each year, your support funds our LSHTM Fund Scholars, enabling exceptional students to study at our School. We receive thousands of applications every year, with funding only available to support a small number. Without support, many brilliant students like this year's LSHTM Fund Scholar, Judy Baariu (MSc Public Health for Development, 2023) would not have been able to study with us.

LSHTM has over 3,500 staff conducting research in more than 100 countries, with core hubs in London and at the MRC Units in The Gambia and Uganda. Our outstanding, diverse and committed staff make an impact where it is most needed - deploying research in real time in response to crises, developing innovative programmes for major health threats, or training the next generations of public and global health leaders and researchers.

We help shape health policy and translate research findings into tangible impact. We are uniquely placed to lead on transformative approaches to global health and have 120 years of experience tackling big challenges. We are focused on finding new solutions to complex problems and acting upon this knowledge.

We work in collaboration with friends, partners, and supporters to achieve large-scale, long-term impact. Researchers at LSHTM explore all aspects of health challenges, from fundamental laboratory science to policy appraisal and analysis, encompassing statistical, clinical, laboratory, epidemiological and social science research globally.

Our aim is to build strong and dynamic leadership, push the frontiers of knowledge and make an impact where it is most needed. Philanthropy helps us achieve our mission; to improve health and health equity worldwide; working in partnership to achieve excellence in public and global health research, education and translation of knowledge into policy and practice.

London School of Hygiene & Tropical Medicine

The Voice of Rare Disease Patients in Europe

EURORDIS is a patient-driven, non-governmental alliance of patient organisations and people living with a rare disease, representing 989 rare disease patient organisations in 74 countries, covering over 4,000 rare diseases. EURORDIS is the voice of 30 million people affected by rare diseases throughout Europe. 

EURORDIS - European Organization for Rare Diseases 

Odylia Therapeutics is a nonprofit biotech working to accelerate the development of treatments for people with rare diseases.

At Odylia, we accelerate therapeutic development for people with rare diseases, changing the way treatments are brought from the lab to the clinic. We strive to bring life altering treatments to people with genetic disease regardless of prevalence or commercial interest. 
Odylia is shifting the paradigm to focus on proven science and removing traditional roadblocks. We work to lower costs, reduce development time, focus research, and continuously drive successful programs towards clinical trials and regulatory approval. Strategic collaborations with patient groups, research labs, and commercial partners facilitate our work to ensure treatments are safe, effective, and ultimately reach patients who need them.

Odylia challenges the traditional approach to drug development through:

1. Lower cost of development
Lower licensing fees to decrease development costs and ensure continued commitment to program success

2. Increase speed of development
Challenge traditional approaches through regulatory engagement

Streamline development through strategic partnerships and a platform approach to drug development

3. Enable the entire ecosystem
Provide expertise through in-house Brydge Solutions and leveraging the Odylia Board

Enable the entire ecosystem through Initiatives that impact the broader field

Odylia Therapeutics

Delivering medical aid where it's needed most — independent, neutral, impartial.

Doctors Without Borders/Médecins Sans Frontières (MSF) is an international medical humanitarian organization created by doctors and journalists in France in 1971.

In over 70 countries around the world, MSF saves lives by providing medical aid where it is needed most—in armed conflicts, epidemics, natural disasters, and other crises.  The people who work for MSF are doctors, nurses, midwives, epidemiologists, water-and-sanitation experts and many others who combine their professional expertise with a commitment to the world’s most vulnerable people.  Each year, these medical teams run close to 470 projects where they care for millions of people.  

As an organization, MSF is neutral and operates independently of any political, military, or religious agendas. It does not take sides in armed conflicts, provides care based on needs alone, and advocates for increased independent access to victims of conflict and disaster as required under international humanitarian law. Medical teams conduct evaluations on the ground to determine a population's medical needs before opening programs, aiming to fill gaps that exist (rather than replicating services that are already offered) or reach communities that are not being assisted.  Over the years, the organization has been the recipient of several awards that recognize its work, including the 1998 Conrad N. Hilton Humanitarian Prize, the 1999 Nobel Peace Prize, the 2012 J. William Fulbright Prize for International Understanding, the 2015 Lasker-Bloomberg Public Service Award, and the 2017 Pardes Humanitarian Prize for Mental Health.

Doctors Without Borders/Médecins Sans Frontières (MSF) 

DMT Quest focuses on discovering innate pathways to unveil the mysteries of human perception as well as potential.

The mission encompasses truths so deep that they can seem “movie-like” at times. It signifies the ultimate quest for answers about life. It will comprise of a comprehensive, interdisciplinary study of the mechanisms related to and responsible for internal dimethyltryptamine (DMT) production within the human body. We believe that the significance regarding naturally produced DMT is potentially far greater than simply providing “hallucinatory” visions within the mind. A combination of transparency in terms of lab results, finances, open discussion, and the journey of the study in video documentary format (as well as audio/written) will provide the platform for the general public to comprehend the implications.

DMT Quest

Dhody Research Institute examines medical history to address health challenges and fosters curiosity through education.

The Dhody Research Institute (DRI) is a 501(c) 3 non-profit dedicated to scientific and museological research,  consultation, and education. Through partnerships with historic, scientific or medical institutions, DRI conducts  research with historical medical collections to improve  21st –century human health. The Institute also provides consultation to institutions and researchers who seek to create museums or exhibitions with a medical historical dimension or maintain their collections of anatomical/pathological anatomy. The DRI also engages in accessible science communication through various social media channels to promote STEM engagement, encourage careers in STEM fields, and engage in science dialog with our wide audience.



Dhody Research Institute

Esophageal Cancer Action Network is a national nonprofit organization. It received its 501(C)(3) nonprofit status in 2008.

**ECAN's mission is to SAVE LIVES.**

We do it by:

- Sounding the alarm that reflux disease can cause deadly Esophageal Cancer,
- Promoting early detection of Esophageal Cancer and its precursor, Barrett's Esophagus,
- Supporting increased medical research to prevent, detect, treat, and *cure* Esophageal Cancer, and 
- Providing patients and families with important education and compassionate support.

ECAN’s Board of Directors is comprised of top medical professionals, business leaders, patients, and family members who have been touched by Esophageal Cancer. A national non-profit organization based in Baltimore, Maryland, 

ECAN provides patients and families with support during their journey, tools to raise awareness, and a chance to advocate for progress to increase survival and quality of life for patients – and slow the increase of this disease in the future.

ECAN's advocacy has increased the federal research budget for Esophageal Cancer by nearly $20 million over the past four years. ECAN's awareness-raising efforts reach more than a million individuals each year. Our educational programming gives patients and caregivers up-to-date, reliable information they need to make well-informed decisions.

Esophageal Cancer Action Network

One of GiveWell's top charities for the past several years, AMF provides anti-malarial bednets to people in need. 

From Givewell: 
What do they do? AMF (againstmalaria.com) provides funding for long-lasting insecticide-treated net (LLIN) distributions (for protection against malaria) in developing countries. (More)

Does it work? There is strong evidence that distributing LLINs reduces child mortality and malaria cases. AMF conducts post-distribution surveys of completed distributions to determine whether LLINs have reached their intended destinations and how long they remain in good condition. AMF's post-distribution surveys have generally found positive results but have some methodological limitations. (More)

What do you get for your dollar? We estimate that the cost to purchase and distribute an AMF-funded net is $4.95, or $4.65 excluding in-kind contributions from governments. The numbers of deaths averted and other benefits of distributing LLINs are a function of a number of difficult-to-estimate factors, which we discuss in detail below. (More)

Is there room for more funding? We believe that AMF is likely to be constrained by funding. We estimate that AMF could use up to an additional $37.8 million to support LLIN distributions that will occur between now and late 2023. 

AMF is recommended because of its:

Focus on a program with excellent evidence of effectiveness and cost-effectiveness.
Processes for ensuring that nets reach their intended recipients and monitoring whether they remain in homes and in good condition over the long-term.
Room for more funding – we believe AMF will be able to use additional funds to deliver additional nets.
Transparency – AMF shares significant information about its work with us and we are able to closely follow and understand its work.

The Against Malaria Foundation

ConnectMyVariant's mission is to end hereditary disease by bringing families together.

ConnectMyVariant is an educational health-focused 501(c)3 nonprofit organization that supports individuals and families with hereditary disease in their early detection and prevention efforts. We provide unique value by leveraging our evidenced-based family connection protocols to help people identify other at-risk relatives and help those relatives access genetic testing so that they can get optimal medical care. ConnectMyVariant brings people with the same genetic risk together through our variant database and community engagement events to share experiences and find common ancestors. ConnectMyVariant also works to increase awareness of the benefits of family outreach among physicians, others who provide prevention care, and the broader genealogy community.
 
Our key activities are:
   - Working with patients to implement personalized family outreach plans
   - Interactive educational workshops about sharing information on inherited disease risk
   - Variant specific family reunions to share stories and plan outreach to cousins
   - Genealogy assistance to help connect individuals in variant groups
   - Individual equity and inclusion grants for family and community outreach

Need and Impact:
When hereditary disease risk is known, family outreach has been proven to be the most effective and cost-effective intervention for early detection and prevention. This family outreach, also known as cascade testing, is recommended by multiple guidelines. Despite overwhelming evidence, family outreach assistance is not reimbursed by insurance or integrated into healthcare. Many people suffer and die from hereditary disease that could have been prevented or caught early.
 
We have shown that our strategies to encourage family outreach can act as a communication multiplier. Our pilot research at the University of Washington showed that this approach enhanced patient experience, was considered ethical, and was appreciated by newly identified relatives. Our approach is low-cost and is 25 to 50 times more effective than awareness and education interventions that target the general population.

Equity and Inclusion:
ConnectMyVariant is committed to being a leader for equity, diversity, and inclusion in hereditary disease prevention. ConnectMyVariant’s goal is to spread awareness among all individuals and families about inherited disease risk. All project staff, participants, and partners in ConnectMyVariant have an equal voice in developing innovative ways to improve hereditary disease outreach and prevention for all people. By fostering a diverse and inclusive community, we can provide knowledge and opportunities that have been historically inaccessible to millions of people.

ConnectMyVariant

YOU bring real, lasting social change in the Democratic Republic of Congo(DRC). Join us.

“Women are the first victims of war, but only they hold the unique key to peace.” – Julienne Lusenge 
 
 The Fund for Congolese Women (FFC)   supports women's grassroots organizations through financial and technical assistance.  FFC is unique - the only women-led grant-giving NGO in the entire DRC. We provide grants to local women-led organizations that are often in the most remote, difficult to reach areas.   Why? We are unshakable believers in local solutions to local issues.  We know that the brave women and girls working at the grassroots level have the solutions. We know that when women become agents of change, they benefit, their families benefit, their communities benefit. Since its inception in 2007, FFC has funded more than 386 projects throughout the Democratic Republic of Congo. We support projects focusing on eliminating sexual violence against women, delivering empowerment programs for women and girls, educating women about HIV/AIDS and reproductive health, and advocating for environmental justice and access to resources and land for women.  Generous individuals like you make our work possible.  Thank you! 
 
 
 Join the conversation and follow us on Twitter and like us on Facebook.

Fund for Congolese Women (FFC)

We provide cash incentives for childhood vaccinations. It’s one of the most cost-effective ways known to save lives.


New Incentives’ mission is to save lives in a way that does the **most good per dollar**.
Guided by evidence, we provide cash incentives to increase childhood vaccination rates.

- We [raise awareness](https://www.newincentives.org/blog-posts/awareness-activities) about the benefits of childhood vaccinations.
- We [provide cash incentives](https://www.newincentives.org/blog-posts/a-day-in-the-life-abubakar-aliyu-field-officer) at government clinics after children receive vaccinations.
- We [help improve the vaccine supply chain](https://www.newincentives.org/blog-posts/supporting-government-partners-with-vaccine-supply-efforts) to ensure enough vaccines are available at clinics.

Together, these efforts are proven to double vaccination rates and save lives.
Learn more about the [randomized controlled trial](https://www.newincentives.org/rct-results).

As of March 2024, New Incentives has reached more the 3 million infants in northern Nigeria.

New Incentives

We are a research hospital that treats patients in all medical disciplines, focusing on oncology, neurology, and diagnosis.

The Fondazione Casa Sollievo della Sofferenza – Opera di San Pio da Pietrelcina (transl. Home for the Relief of Suffering Foundation – Work of Saint Pio of Pietrelcina) is a not-for-profit research hospital located in the city of San Giovanni Rotondo (FG), in the Puglia Region, Southern Italy.
As per Canon 1303 §1 of the Code of Canon Law, it has public, canonical and civil legal personality; it is therefore subject to the supervision of the Holy See and, on its behalf, of the pro-tempore Cardinal Secretary of State. 
Many of the stages that have thus far marked the history of the Work of San Pio of Pietrelcina have been achieved thanks to the loving generosity of many benefactors who, sharing the mission indicated by San Pio da Pietrelcina, the relief of suffering, wanted to donate to his work.

HISTORY
The hospital was founded and inaugurated by Saint Pio of Pietrelcina on May 5, 1956 with a capacity of 250 beds. It took on the status of Provincial Hospital on 4 August 1971 and then of Regional General Hospital on 2 June 1980, thus becoming part of the Italian National Healthcare System. Since 16 July 1991, with a Decree of the Minister of Health and the Minister of University and Scientific Research, it has been a Research Hospital. Originally, the object of its scientific activity was limited to genetic and hereditary-familial diseases; subsequently, the Minister of Health, by the 5 December 2012 Decree, extended the research areas of its competence to "Genetic diseases, innovative therapies and regenerative medicine". Recently, on the occasion of the presentation of the research lines for the three-year programme of the Italian Research Hospitals 2022-2024, Casa Sollievo identified “Diagnostic acitivity, Neurology and Oncology” as its main research thematic areas, thus becoming a polythematic Research Hospital.

MISSION
The Foundation's mission is to provide health care and carry out research activities. In addition, the Foundation offers training activities for its personnel.
Around 2,750 people work at the Foundation.
The Foundation (hereinafter “CSS”) consists of three structures based in San Giovanni Rotondo: the hospital Casa Sollievo, the polyclinic Giovanni Paolo II, where outpatient activities are carried out, and the ISBReMIT research center for regenerative medicine (Institute for Stem-cell Biology, Regenerative Medicine and Innovative Therapies); and the Mendel Institute in Rome, where research and diagnostic activities are carried out. In San Giovanni Rotondo, it also owns and runs a retirement home for the elderly.
In addition, CSS owns 3 hospitality facilities where affordable accommodation is offered to hospitalized patients’ relatives who have to assist them; and another facility (Casa Zeni) where accommodation is offered free of charge to the parents of the little patients hospitalized in the oncology-hematology unit.
Moreover, the Foundation includes the Padre Pio Prayer Groups Centre, which was also founded by San Pio and coordinates the Padre Pio prayers groups throughout the world, according to the Founder’s wish that Prayers Groups live and testify the importance of prayer and pray for CSS.
Lastly, CSS publishes a monthly periodical and posts on the Foundation’s official channels on the web updates on its research and clinical activity and its spiritual activity and the teachings of the Founder.
The hospital offers assistance also to people from underdeveloped countries. 
Moreover, a free-of-charge shuttle service has been provided for many years to radiotherapy patients coming from Bari and surrounding cities (Southern Puglia).

THE CLINICAL ACTIVITY
CSS has around 756 beds, 38 medical and surgical inpatient units, 26 operating rooms, in addition to services, diagnostic and multi-specialist outpatient units.
In 2022, the hospital recorded over 30,000 hospitalizations and 870,000 outpatient performances. 
Regarding the advanced technological equipment, CSS has 1 "Da Vinci" surgical robot, 1 PET/CT device, 3 linear accelerators, 4 CT devices, 1 CT simulator for radiotherapy, 4 NMR equipment, 3 digital angiographs, 2 gamma cameras and a RIS/PACS system for the filmless management of the radiology department.
Furthermore, CSS hosts an Umbilical Cord Bank and a Human Milk Bank.
Recent Achievements
In addition to the many important activities carried out in CSS, 3 new units have been opened: 1. a new Emergency Room hosting an Observation and Assessment Ward; 2. an Hematopoietic Stem Cell Transplant Center. 3. an Sub-Intensive Geriatric Unit. 
CSS has also established a Stroke Unit, a Lung Unit, a Breast Unit, a Head and Neck Unit, and a Molecular Tumor Board to guarantee appropriate, quality and homogeneous procedures.
Future goals
Important technological investments have been planned for the years 2023-2025 in the following areas: oncology/nuclear medicine, diagnostic imaging, ICU, and surgery. 

THE RESEARCH ACTIVITY
The research activity is conducted in the Polyclinic, the ISBReMIT research center and at the Mendel Institute, for a total of 17 research groups.
Recent achievements
The consolidated experience of the staff working in CSS in the study of genetic diseases since 1991 and the continuous updating of technologies, instrumentation and genomics and post-genomics skills have made it possible to direct the research and clinical-assistance activity towards two complementary research lines: "personalized medicine - system biomedicine" and "regenerative medicine" based on the study of tumor stem cells and the use of normal stem cells.
The scientific fields in which the Institute is mostly involved in "personalized medicine" concern the identification of the genetic causes of rare diseases and the identification of diagnostic, prognostic and predictive markers in complex pathologies, including tumor pathologies. Regarding the identification of the genetic causes of rare diseases, we use the new next generation sequencing (NGS) technologies and the skills acquired by the bioinformatics unit, one of the first established at national level. In parallel, the Institute boasts a large collection of induced pluripotent stem cells (iPSCs), produced from patient fibroblasts, in which pathogenetic variants have been identified, and use the skills acquired in differentiating them into mature cells, in particular astrocytes, neurons and oligodendrocytes.
Regarding regenerative medicine, two important studies were conducted and concluded: a phase I trial on anti-Multiple Sclerosis therapy based on the use of human neural stem cells, approved by the Ministry of Health and the Italian Medicines Authority AIFA (EudraCT code 2015-004855-37); and a phase I/II trial on anti-glioma therapy with biological drugs (EudraCT code: 2016-001761-92). The results of these studies will published in prestigious international journals.
In 2015, the new ISBReMIT Regenerative Medicine Research Center was started. It is a cutting-edge structure in terms of conception and equipment in the field of translational medicine for genetic, degenerative and oncological diseases. The structure hosts, together with the highly technologically equipped laboratories, a cell factory and a laboratory for the production of biopharmaceuticals under Good Manufacturing Practice, i.e. for clinical use, including somatic stem cells and iPS, vectors for gene therapy and biomaterials.
It should be noted that CSS has recently become part of three Networks of the Italian Research Centers: since 2016 it has been an Ordinary Associate of Alleanza Contro il Cancro; since December 2018, of the National Research Network on Aging; and, finally, since March 2020 of the Neuroscience Network. Starting from 2022, CSS has been part of the European reference networks for rare and uncommon diseases (European Reference Networks - ERN), in particular ERN-SKIN on diseases of dermatological interest, and ERN ReCONNET on musculoskeletal diseases and pathologies of the connective tissue.
Researchers publish about 200 scientific articles in the most renowned journals (Science, New England Journal of Medicine, Nature Genetics) every year. They are engaged both as Principal Investigators and as partners in research projects in the biomedical field and ICT, obtaining funds from the EU (H2020 and FP7) and national or regional calls.
CSS is also a partner in Research and Innovation projects funded by private and public bodies, e.g. from the EU both under Horizon 2020 and Horizon Europe, in the field of digital transformation of healthcare. The main areas of involvement concern Assistive Robotics, Artificial Intelligence, Big Data generated by consumer devices, eHealth, Digital Therapies, the Internet of Things and Cybersecurity.
Future goals
Starting from the identification of the genetic causes of diseases, the goal is to develop advanced therapies to bring to the patient's bedside and tailored to him/her.
Furthermore, at the end of 2023, the phase II study "Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis: A multicenter, randomized placebo controlled and biological endpoints clinical Trial" (EudraCt 2018-002373-22) will be launched. This involves the use of neural stem cells on patients suffering from Amyotrophic Lateral Sclerosis.

CONCLUSION
Casa Sollievo della Sofferenza was born of the visionary mind of a poor friar, one of the most important, recent and internationally recognized and prayed Saints, Saint Pio of Pietrelcina, right after the II World War, in a poor corner of the Southern Italy of those times. 
CSS, by its Statutes, is a not-for-profit organization. All the good work that has been done until now for the sick has been possible thanks to the generosity of donors and to the public and private funds that have been collected through the hard work of the Foundation’s researchers and clinicians, thus contributing importantly to the care of citizens from Southern Italy and underdeveloped countries and to the world research.

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza - Opera di San Pio da Pietrelcina

Protecting sight and fighting for disability rights

Sightsavers works in more than 30 countries worldwide, focusing on Africa and Asia.
We work with local, regional, national and international partners and governments. With their help, we distribute treatments to prevent disease, carry out eye operations, advocate for disability rights and improve health services to create sustainable development projects. 

Our vision is of a world where avoidable blindness is eliminated, and people with disabilities have the same rights as everyone else. We can only get there thanks to the generosity of our supporters, so we aim to be as transparent as possible so you can be sure your money is being used wisely.

Sightsavers



This is about bringing permanent changes to healthcare safety and quality! 

Mission Statement-
National Nurses March, we value peaceful lifting of our nurse
voices united on a national level in an effort to be heard that
will promote change nationally for nurses for fair realistic
wages; including no caps, safe staffing, no violence against
healthcare workers, and changing the culture of the biases and
discriminations in the nursing profession.

National Nurses March is a project of Players Philanthropy Fund, Inc., a Texas nonprofit corporation recognized by IRS as a tax-exempt public charity under Section 501(c)(3) of the Internal Revenue Code (Federal Tax ID: 27-6601178, [ppf.org/pp](https://ppf.org/pp)). Contributions to National Nurses March qualify as tax-deductible to the fullest extent of the law.

National Nurses March

Supports highly-impactful, evidence-based solutions to the challenges of global poverty and inequality.

The Global Health & Development Fund addresses the vast inequalities in health, wealth, and opportunity.

While many people alive today can expect to have greater wealth than generations before us, millions of people live in poverty, and billions more struggle to get by. They may lack access to basic healthcare and vaccinations, making them far more vulnerable to deadly diseases, or to quality education, which strengthens their economic future. These are complex, but not unsolvable, problems. Researchers, advocates, and organizations around the world are working to scale up solutions to these problems. By taking a thoughtful, evidence-based approach to philanthropy that accelerates the best of these solutions, we can do immense good.

The Founders Pledge Global Health and Development Fund identifies and supports highly-impactful and neglected development initiatives. By pooling donations and collaborating with other funding and research organizations, this Fund allows individuals to make contributions when and where they will have the largest impact. We aim to:

- Significantly improve the lives of the world's most vulnerable people;
- Eliminate deaths from easily preventable disease;
- Support sustainable, systemic change.

### Our Approach to Grantmaking

When evaluating potential grants, we consider several key points:

- **Counterfactual impact**. Our grants are designed to create a meaningful outcome that would not otherwise have happened. This means that you can rely on the Funds to create meaningful, real change, rather than just maintaining the status quo.
- **Impact-driven philanthropy**. This fund prioritizes the highest-impact solutions to challenges. We assess where the gaps are, which opportunities may be neglected by other funders, and where the biggest wins are in terms of making the biggest difference.
-  **The organization’s funding gap**. Not all organizations are set up to scale up their programming and some may not be able to productively absorb large amounts of unsolicited funding at any given point. We evaluate all potential grantees’ capacity for growth and consider how much money they could put to good use.
-  **Organizational strength**. Particularly with unrestricted funding, it’s important to have trust in the leadership and capacity of the organizations we support. We look at their track record of success and their transparency about failures as well as successes, and we only support those organizations which are exceptionally well run.
- **Time-critical opportunities and funding certainty**. While Founders Pledge members give to our top climate charities regularly, sometimes there are time-critical opportunities which require fast decisions. We will use the Fund to make grants that enable such short-term opportunities and stability for high-impact funding opportunities thereby increasing the impact compared to individual giving to specific organizations.

### Frequently-Asked Questions

**Can charities apply for money from the Fund?**

The Funds do not generally accept applications from charities, and we request that charities do not send unsolicited applications for funding. If the Fund Managers choose to open up an application round, this will be publicized. 

**How frequently will you make grants from the Fund?**

In general, Fund Managers will review grantmaking decisions on a quarterly basis. Decisions will be made based on the value of Funds and the available options for high-impact grantmaking. We may disburse funds outside of quarterly review dates if we become aware of a particularly promising and time-sensitive funding.

**How will my contribution be used?**

All funds are granted out. The Fund is not an investment vehicle. The Fund does not use any percentage of contributions to cover staff time or other overhead costs. Every dollar contributed to the Fund will be used to make grants directly to end-user organizations creating a real difference.

### More Questions?

To learn more about the Founders Pledge Global Health and Development Fund, please visit [founderspledge.com](https://founderspledge.com/funds/global-health-and-development-fund) or email the Fund Managers at [funds@founderspledge.com](mailto:funds@founderspledge.com).

Founders Pledge: Global Health & Development Fund

Our mission is to protect LGBTQ+ youth in Poland from the harms of homelessness and refugeehood. 

The Warsaw House Foundation's mission is to protect homeless and refugee  LGBTQ+ youth in Poland and provide them with the tools they need to live independently. Our inspiration was the  Ali Forney Center  (AFC)  n NYC, which is largest organization in the world offering support to homeless LGBTQ+ youth. We are honored that Carl Siciliano, the AFC's founder is on the board of the Warsaw House Foundation and works as an advisor. We place extra attention on HIV and STI education, support and prevention with the help of board member Dr. Joanna Kubica and the Smart Life Clinic in Warsaw.  After we took in our first LGBTQ+ youth to house on February 14th, 2023  we have been flooded with calls for housing and support from young people in need.  These are Polish Trans 18 year-olds from the Polish countryside in desperate need to escape their abusive and intolerant homes, young queer people with PTSD and untreated mental illness who need housing and support immediately, LGBTQ+ refugees from Ukraine and several young gay men from Iraq who suffered torture in their homeland, were detained and imprisoned at the Polish/Belarussian border for up to two years, and are now trying to build their lives in Poland.  We are also housing and supporting young LGBTQ+ people from Uganda and Egypt,  We are raising money to support the young people under our care, to house and feed them and pay for their medical needs and courses needed for them to start an independent life,  We are also raising money to hire staff (all of WH's work is now done by volunteers), to continue the renovation of our residential building and for short term emergency rentals.  We have a committed and professional team and a well planned strategy for both emergency and long term care.  Any help would be greatly appreciated!! We will be in regular contact if you'd like to hear of our progress and  if you'll be in Warsaw, we'd be delighted to meet with you personally and show you the work we do.

Warsaw House Foundation

Caritas Manila is the social service and development ministry of the Archdiocese of Manila.

Caritas Manila is one of the largest church-based nonprofit organizations in the Philippines. It is a Spirit-led community committed to serving the poor—the “least, last, and lost” in society.

Its programs are geared towards total human development, poverty alleviation, and the creation of a Christian community with a strong social conscience.

*Programs:*

**Youth Servant Leadership and Education Program (YSLEP)**

Caritas Manila believes that *education* is the *best social equalizer.*

YSLEP is Caritas Manila's flagship program. It forms future leaders from the poor by *providing scholarships and formation sessions* to around 5,000 youths nationwide.

**Caritas Damayan**

Damayan is the umbrella program of Caritas Manila that covers: (1) preventive health, (2) plant-based food security, (3) feeding and nutrition, (4) crisis intervention, and (5) disaster relief and rehabilitation.

Its sub-programs are:

1. **All is Well** - Through the help of its partners in the medical field, Caritas Manila *offers health services in 28 clinics* in Mega Manila.
2. **Gen129** -** This program advocates lifestyle change through plant-based living. In this program, we teach the poor *how to grow their own food* for a more sustainable future.
3. **Munting Pag-asa** -** This program aims to *counter malnutrition* by providing healthy supplemental meals to poor malnourished children for 120 days.
4. **Unang Yakap** -This program provides healthy meals and vitamins to *poor pregnant/lactating mothers* for 120 days to ensure the optimum health of the mother and their child. Beneficiaries also receive seminars on financial literacy to improve their living condition.
5. **Caritas in Action** - In cooperation with Radio Veritas 846, the CIA program provides medical, legal, hospital bill, laboratory, psychosocial, and burial assistance.
6. **Cadamay** - It *provides emergency relief response* within 24 to 72 hours by distributing food packs, hygiene kits, bedding materials, and shelter repair kits. It also provides livelihood assistance to victims of calamities and church reconstruction assistance to affected parishes.

**Restorative Justice**

It is a program designed to *help Persons Deprived of Liberty (PDLs)* heal their relationships with their families and the community. It also aims to help them be reintegrated into society as self-sufficient individuals.

**Sanlakbay**

Sanlakbay para sa Pagbabago ng Buhay is a parish/community-based rehabilitation program that aims to transform lives, restore human dignity, and *reintegrate* d*rug dependents* into their communities.

**Segunda Mana**

It is the donated goods program of Caritas Manila that *converts in-kind donations into cash* in our 47 charity outlets in Mega Manila to:

- Fund over 5000 tech-voc and college YSLEP scholars
- Support the livelihood of over 300 micro-entrepreneurs and their families from informal sectors like BASECO and Payatas
- Strongly promote the 3Rs (Reduce, Reuse, and Recycle)

**Institute for Servant Leadership and Stewardship (ISLaS)**

ISLaS is the *volunteer arm of Caritas Manila* which mobilizes around 5,000 volunteers within the Archdiocese of Manila.

Parish-based leaders and volunteers undergo continuous training and values formation that mold them to become committed servant leaders. These volunteers enable us to efficiently and effectively implement various social services and development programs for poor families in their communities.

*"For the love of Christ urges us on..." - Corinthians II*

Caritas Manila, Inc.

Fighting HIV/AIDS through innovative research and education 

First established in 1996 during the height of the HIV/AIDS epidemic in Botswana, the Botswana Harvard Health Partnership (BHP, formerly the Botswana Harvard AIDS Institute) is a collaborative research and training initiative undertaken jointly by the Government of Botswana and the Harvard TH Chan School of Public Health. Located in Gaborone, Botswana, BHP houses the Botswana Harvard HIV Reference Laboratory, one of the largest HIV/AIDS laboratories in Africa, which serves as the reference testing lab for all HIV activities in Botswana.  A world-renowned educational institution of excellence in research and education pertinent to HIV/AIDS and other emerging public health challenges, BHP has between 250 and 300 employees at any given time, several active clinical research sites throughout the country, and high-functioning data, research laboratory, regulatory/ethics, human resource, finance, and administrative offices. One of the core missions of BHP is to build capacity through training African researchers, clinicians, and public health leaders. Dozens of African investigators and thousands of health workers have trained through BHP, at least half of them women.

BHP has partnered with the US branch of the Belgium-based King Baudouin Foundation (KBFUS) and their partner Every.org to accept donations from outside Botswana on BHP’s behalf. Both KBFUS and Every.org are 501(c)(3) public charities in the United States (EIN 58-2277856 and 61-1913297, respectively), so US-based donors may claim the maximum tax benefits allowed by US law for their contributions. A donation acknowledgement will be provided for this purpose. Additional information is available at the Donate link above and at https://kbfus.org/, or feel free to contact Lendsey Melton at Harvard, either by email at lmelton@hsph.harvard.edu or by telephone at +1-617-432-0975, if you have any questions.

Botswana Harvard Health Partnership

LEEP advocates to prevent lead poisoning and improve the health, wellbeing, and potential of children worldwide. 

LEEP advocates for regulation on lead paint to reduce lead poisoning and improve the health, wellbeing, and potential of children worldwide. Lead poisoning is a colossal issue causing disability in 815 million children worldwide.

Currently, we are working on programs in Malawi, Zimbabwe, Madagascar and Pakistan, and are looking to expand to another 7 countries in the next year.

To learn more about our work, check out:
https://leadelimination.org/projects/
https://leadelimination.org/faqs/
https://leadelimination.org/blog/

Thank you for helping us to address the problem of lead poisoning, and improve the health of children worldwide.

Lead Exposure Elimination Project (LEEP)

A care center for patients with thalassemia, hemophilia, or other blood disorders.

Dastak Welfare Foundation

Helen Keller, our co-founder, envisioned a world without barriers to human potential. We are continuing her work.


Helen Keller, our co-founder, envisioned a world without barriers to human potential. Guided by her fierce optimism, we have been working on the front lines of health and well-being for more than 100 years. We deliver life-changing health care to vulnerable families in places where the need is great, but access is limited. Our proven, science-based programs empower people to create opportunities in their own lives.


Helen Keller International

We help people in crisis by providing emergency health services, and then promote self-reliance through training.

We are a global humanitarian organization dedicated to saving lives and relieving suffering. Established in 1984 by volunteer doctors and nurses, we are a nonprofit with no political or religious affiliation, and now have more than 7,500 staff members around the world, more than 97% of whom are local. Our mission is to improve the quality of life through health interventions and related activities that strengthen underserved communities worldwide. With the flexibility to respond rapidly to emergencies, we offer medical services and training to people at the highest risk, always working to strengthen local healthcare systems and promote self-reliance.

International Medical Corps

We give small mills everything they need to add vital nutrients into the food that millions of malnourished people eat the most.

Sanku combats hidden hunger and saves lives by giving small mills the tools needed to fortify maize flour, an East African staple. Our mission: Guarantee that every meal consumed by every mother & child contains vital nutrients, forever. 

Worldwide, 8,000 children die every day and 2 billion suffer from preventable illness because their diets lack basic vitamins and minerals. Fortification (adding life-saving micronutrients to processed foods) is the most cost-effective nutrition intervention, but it has failed to reach the 6.5 billion people in developing countries who rely on small, often rural, mills for most of their food.

Sanku developed a technology and business model to enable the small mills that feed the most malnourished people to conveniently and affordably fortify staple grains. Our technology adds precise levels of nutrients into flour during processing and our business model leverages economies of scale to offset any additional costs for millers and their customers, providing Sanku with revenue margins that increase as we scale. We are currently reaching 3 million East Africans with the basic human right of nutritious food and have a plan to reach 100 million this decade, which will prevent millions from death and disease, boost productivity, and save billions of dollars in GDP.  

A donation of ~$1 is enough to give one person access to nutritious food for an entire year, so even a small donation can go a long way in the fight against malnutrition.

Sanku

The END Fund is the only private philanthropic initiative solely dedicated to ending the most common neglected tropical diseases.

Our Mission: To control and eliminate the most prevalent neglected tropical diseases (NTDs) among the world's most vulnerable communities and people by 2030. 


NTDs are a group of parasitic and bacterial diseases largely prevalent in tropical regions that currently receive little attention on the global health agenda yet have a significant impact hampering the potential of individuals and communities at large. The devastating effects of NTDs include irreversible blindness, severe disfigurement, stunted cognitive and physical development, especially in children, malnutrition, social isolation, and more. NTDs also cause 170,000 deaths per year. Their comprehensive impact on all aspects of daily life means that the presence of NTDs costs affected countries billions of dollars per year in lost productivity, out-of-pocket expenses, and reduced socioeconomic and educational attainment. 

Currently, 1.7b individuals are affected by such diseases. However, the treatments and knowledge required to eliminate these diseases are readily available, with the annual cost of treatment per individual averaging 50 cents per year. Demonstrating the uniquely cost-effective impact of NTD treatment, studies have shown treatment is the single most efficient means of improving children’s school attendance and capacity to learn. A recent report by Deloitte on Nigeria showcases the significant gains affected economies stand to make should NTDs be eliminated, with Nigeria’s economy estimated to receive an $18.9b boost from now until 2030. The report is available to view here - https://www2.deloitte.com/za/en/nigeria/pages/strategy/articles/Ending_The_Neglect.html

The END Fund helps ensure those at risk of NTDs need not experience such preventable suffering but can live healthy and prosperous lives instead. We do so by working in close partnership with stakeholders across the global NTD community to identify and fulfill gaps and needs in NTD funding, design programs, strengthen the capacity of local actors, provide technical support, and assist with monitoring and evaluation, amongst various additional activities. Our work helps children stay healthy and in school, prevents advanced cases that cause disability and restrain individuals' productive potential, and alleviates the disproportionate disease burden faced by women and girls, as well as the economic burden of disease on families. We have distributed more than 1.2b treatments since our founding in 2012, with 118m individuals treated in 2021 alone.

We envision living in a world in which all have the opportunity to achieve their full potential, with these diseases that have plagued humans for millennia confined to history once and for all.

The END Fund

Ladli Foundation Trust is  Fostering gender equality, promoting Indian traditional practices for sustainable living globally.

​Ladli Foundation USA, A 501 (C)(3) registered charity organization, incorporated in the 2021 as NJ non-profit organization. It is an international wing of Ladli Foundation Trust India, a well-known non-profit organization. It is an International wing of Ladli Foundation Trust, India, a grassroots level organization known for implementing incredibly impactful & innovative social initiatives to uplift vulnerable people in urban & rural slums and directly impacted over **Two Million beneficiaries** through its action-research initiatives. It was granted the Special Consultative Status in Economic and Social Council since-2020 and conferred with the National Award by the Govt of India for its effective social development non-profit works across the India & also **working with USAID for enhancing the Coverage of Routine Immunization, Covid-19 vaccination & Eradication of Tuberculosis in India**.



**​Inception- Ladli Foundation, India**

Driven by concerns of health, education &amp; equality for vulnerable women as an integral and critical dimension of human rights, Ladli Foundation became a reality in 2012 as a grassroots social catalyst. It was founded by Devendra Kumar, whose incredible journey began as a child laborer in a poverty-stricken environment. Where he faced numerous hardships and atrocities during his orphaned and challenging childhood. Born in a crime-prone slum, he endured abandonment by his parents, who left him with his three-day-old infant sister when he was just two years old. Despite these adversities, Devendra's indomitable spirit and resilience led him to find solace and purpose in serving others.

Driven by his determination to protect his sister from child marriage and dowry, Devendra founded the Ladli Foundation with the noble mission of uplifting the oppressed and disadvantaged. His personal experiences as a child laborer and his encounters with delinquents and drug addicts further fueled his commitment to making a positive impact in the lives of those facing similar challenges.

Listed as a credible public charity organization by the Niti Aayog- the highest policy-making body of the Government of India and accredited with various union, states governments It has been and is known to bring positive reformative changes in society with a mission of building gender-sensitized inclusive society with equal access to basic, essential amenities and services, healthcare, education, work-force participation etc by women- the foundation has been diligently working in 50
districts across 12 states in India.

Ladli Foundation USA

A social initiative of Udhavum Ullangal Public Charitable Trust, poised to transform the landscape of cancer care in Tamil Nadu.

We are 24yr old charitable trust, in Chennai, working in the areas of cancer care, women empowerment and education. We channel the goodwill of communities and bring hope to people in need.

Since 2011 our Nellai Cancer Care Centre in Tirunelveli has been offering comprehensive cancer care services to underprivileged people. **We have so far raised awareness for over 200k+ people, screened more than 60k+ individuals, conducted over 2800 cancer camps, treated over 1500 patients, and currently provide home-based mobile palliative care services to over 300 patients**. All our initiatives align with the **WHO framework** for cancer care and **SDG Goal 3** for health and wellbeing.

We are now working towards establishing our very own cancer speciality hospital to bridge the growing access-affordability gap in cancer care in Tirunelveli.

Our **[Nellai Cancer Hospital](http://www.nellaicancerhospital.org/)** - a 70-bed facility - will be situated on [a 5.35-acre lush landscape in Sengulam](https://youtu.be/Ij3ErArnajw?si=Gkau13HtITZ3k9Bl) to serve 2 million across the region, spanning several districts.  Equipped with state-of-the-art diagnostics and inpatient care, it is poised to deliver high-quality and holistic cancer care services to patients.

The entire project is being **guided by the Cancer Institute (WIA)** in Adyar, Chennai and several eminent advisors across industries.

So far we have

1. Acquired 5.35 acres of land for the hospital, generously donated to us.
2. Developed a comprehensive architectural plan for a 70-bed hospital, with the initial phase 1 covering approximately 29,000 sq. ft. 
3. Secured the necessary approvals to construct up to 40,000 sq. ft. at the site. 
4. Conducted the ***[Bhoomi Puja](https://www.youtube.com/live/qNl9qWsvjqg?si=6E1LBlWtNRqTWTG4)*** for the project, in the presence of the District Collector of Tirunelveli
5. Began construction in May 2024
6. Assembled an expert programme management team

Generous philanthropists have supported this initiative due to our high credibility and financial transparency. We are

- **Foreign Contribution Regulation Act (FCRA) Complainant**
- 80G Tax exemptions under the IT Act
- CSR Registration, Ministry of Corporate Affairs.
- **1st NGO in Chennai to be** was **registered on the Social Stock Exchange.**
- Due Diligence was carried out by Charity Aid Foundation (CAF), Give2Asia and several MNCs including Accenture, Cognizant Foundation, United Way of Chennai, BankAM, NatWest Group, and WIPRO.

Nellai Cancer Hospital 

Re-imagining healthcare for vulnerable and underprivileged people in Athens, Greece.

**IRIS Humanitarian Response** is a health focused Christian non-profit organisation based in Athens, Greece.

We are dedicated to advancing access to healthcare and delivering high quality medical care for individuals and communities in need. Our goal is to bridge the gap in health disparities and improve health outcomes for disadvantaged and underserved people. Through our work, we strive to make a lasting impact by promoting health equity and the human right to health.

Our mission is to serve vulnerable, marginalised, underprivileged individuals and communities by improving their health and wellbeing - with the ultimate goal to alleviate suffering and restore their dignity and hope.

We are committed to achieving this through:

• upholding the right to health
• providing medical services in the areas of promotion, prevention, treatment and rehabilitation
• ensuring access to medicines and health products
• implementing public health interventions
• removing obstacles and creating innovative ways to access and navigate essential healthcare services

IRIS Humanitarian Response

A movement of people revolutionizing charitable giving to end extreme poverty.

We motivate people to donate 1% or more of their income to the world’s most cost-effective charities, every month, for life. We update this portfolio every year, so your donations are always as impactful as possible.

One For The World Inc

Dedicated to the understanding, treatment and ultimate cure of substance use disorder by funding cutting-edge research. 


Cure Addiction Now (CAN) is dedicated to the understanding, treatment and ultimate cure of drug addiction. Funding basic research and its clinical translation through a collaborative program is the core focus of the foundation. In addition to creating new therapies to help stop the deadly cycle of addiction, we hope to eliminate the negative stigma of this disease and ultimately find a cure for the brain’s addiction to drugs. 

Background:
Nancy Davis founded CAN in 2018 with her son Jason Davis who tragically passed away in 2020. Jason’s dream was to fund ground-breaking research to find therapies to help stop the vicious cycle of substance use disorder (SUD) and help people not only detox but stay in permanent recovery. CAN also has plans to fund educational campaigns to remove the negative stigma of SUD and change the narrative. Our mission is to cure addiction now. 

At the beginning of Covid 19, one person in the US would die every 11 minutes of an opioid overdose. That number has multiplied dramatically to one person every minute and a half and this does not include other drug overdoses. 70 percent of all deaths are now caused by Fentanyl. Yes, addiction is a real disease and needs to be treated. There is no other disease claiming so many lives. We need to take the stigma of shame away that addicts suffer and treat them with dignity, kindness and compassion the same way we treat everybody else suffering from any disease. We need to raise important funds for our brilliant doctors that represent Mount Sinai, Harvard, UCLA, Scripps, University of Washington and Johns Hopkins and start saving lives. Please Visit our website for more information and a detailed list of our esteemed Scientific Advisory Board and Collaborating Scientists. Below are the currently funded grants from this year. Thank you for your consideration and support!

2021 Grant Awardees: Research Progress Report as of 10/1/2021

Research Project #1: Developing a Strategy to Prevent Relapse to Opioid, Nicotine, 
Alcohol and Cocaine Use with a Single Use Medication
Courtney A. Miller, PhD, Scripps Research

Substance use disorder (SUD) is a chronic, relapsing disorder with a severe lack of treatment options. Associations that have formed during periods of drug use serve as powerful relapse factors by triggering motivation to seek the drug. Recently, we identified the molecular ATPase and driver of synaptic actin polymerization, nonmuscle myosin II (NMII), as a biological target for the selective disruption of these associations. A single treatment with the NMII inhibitor Blebbistatin (Blebb) produces an immediate, seemingly permanent loss of motivation for methamphetamine (METH) and amphetamine (e.g. Adderall) by targeting the associated memories. This occurs without the need for retrieval and without affecting other types of memories, including those associated with other drugs of abuse. In addition to its efficacy in animal relapse models following a single treatment, several properties made Blebb an excellent starting point for medication development. Paramount among these are the molecule’s high brain penetration (thus, lower doses can be used) and rapid clearance from the body and brain (limiting unwanted peripheral and central effects on the body). Unfortunately, Blebb’s activity at cardiac muscle myosin II (CMMII), a protein critical for heart function, was a liability. Through work funded by the NIH, including NIDA, we have developed a preclinical candidate compound, MT-110, that retains Blebb’s high brain penetrance and rapid clearance, but no longer inhibits CMMII. The result is a dramatically improved safety profile and a therapeutic index (ratio of the lowest dose that achieves the desired effect and the highest tolerable dose) of at least 25x. We have filed a non-provisional patent in the US and ten other countries, declared a preclinical candidate, and are now preparing to file an IND with FDA and designing our first in human Phase 1 trial. Recognizing that it would be powerful to utilize the Blebb-based NMII inhibitor to target motivation for other widely used drugs of abuse, particularly opioids, alcohol, nicotine and cocaine, we have begun working on a strategy. Blebb disrupts restabilization of these memories when animals are exposed to reminders associated with the drug of abuse. However, for individuals that use drugs, associations capable of motivating drug seeking can number in the hundreds and even be unconscious motivators. Therefore, it is not feasible for subjects to actively retrieve all “triggers” in a clinical setting for reconsolidation targeting. Interestingly, recent evidence in animal and human studies indicates a similar disruption can be achieved by pairing a reconsolidation disrupting intervention with a small amount of the drug of abuse itself. We now have promising preliminary preclinical data using this strategy that points to the potential for MT-110 in cocaine, nicotine and opioid use disorders. Additional studies to validate and extend these findings are underway. 

Research Project #2: 
Role of chemosensory processing in choroid plexus circuit in drug addiction
Paul J. Kenny, Ph.D. and Stephanie P.B. Caligiuri, M.D., Mount Sinai, New York

Sensitivity to the aversive properties of addictive drugs influences vulnerability to substance use disorders (SUDs). Indeed, aversive reactions to drugs of abuse upon their first usage decreases the likelihood that subsequent use will transition from occasional to habitual. Little is known about the mechanisms of drug aversion. Taste systems guide ingestive behaviors to ensure survival by detecting sweet, salty, & umami flavors, which represent carbohydrates, electrolytes, and protein respectively. Taste systems also detect sour and bitter tastes, which often reflects spoiled or poisonous substances. Intriguingly, most addictive drugs are bitter-tasting plant-derived alkaloids, a class of compounds known to activate taste-2 receptors (T2Rs). In addition to their abundant expression in the oral cavity, accumulating evidence suggest that T2Rs are also expressed outside the oral cavity. Individuals carrying genetic variation in genes that encode components of the T2Rs and related signaling machineries are at increased risk of developing SUDs. With the support of Cure Addiction Now (CAN), we are testing the hypothesis that oral and/or extra-oral T2Rs are activated by opioids and other classes of addictive drugs, and that this action contributes to their aversive properties that protect against SUDs. Using genome editing technologies and cellular assays of T2R function, we have collected compelling data suggesting that drugs of abuse stimulate T2R signaling. We have also shown that the same neurons in brain aversion centers that are activated by consumption of noxious bitter compounds such as quinine are also recruited by drugs of abuse. Moreover, we have shown that genetic manipulations that selectively perturb T2R signaling attenuated aversive responses to drugs of abuse and increases their consumption. Perhaps most surprisingly, we found that T2R-mediated aversive sensory information related to drugs of abuse is routed to the choroid plexus in the fourth ventricle, a secretory organ in the brain, and that manipulating genes in the choroid plexus regulates aversive behavioral responses to addictive drugs. These data reveal a novel chemosensory mechanism that regulates addiction-relevant behavioral responses to drugs of abuse that may serve as a substrate for the development of target therapeutics for SUDs. 

Research Project #3
The Kappa Opioid Receptor: A Therapeutic Target for Negative Affect in Pain and Addiction
Catherine Cahill, Ph.D. and Edythe London, Ph.D., UCLA

Anhedonia is the impaired capacity to experience pleasure from naturally rewarding objects and events.  It is defined as a state of ‘markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day’.  While it is relatively undertreated, it occurs in many neuropsychiatric disorders including substance use disorders and chronic pain. Considering the high comorbidity between negative affective states, such as depression and chronic pain, it is not surprising that anhedonia may be a driver of opioid addiction, where opioid misuse is a predictor of anhedonia. 

Kappa opioid receptor agonists produce dysphoria, depressive-like symptoms and psychotomimetic effects in humans, and they elicit aversion and depressive-like behaviors in preclinical models. A novel kappa receptor antagonist JNJ-67953964 produced anti-anhedonic effects in a recent, multicenter, double-blind, placebo-controlled, randomized clinical trial.  Given the involvement of this receptor in negative affective states and the positive preliminary clinical study in alleviating anhedonia, our studies focus on kappa receptors with the goal of facilitating the development of medications for Opioid Use Disorder.

Our first aim was to determine the association of kappa binding in limbic regions of brain with measures of negative affect in a model of chronic pain. To date, we have demonstrated kappa receptor binding in the striatum using microPET and 18F]LY2459989, a novel kappa radiotracer. Binding of this tracer was blocked by both a kappa-receptor selective antagonist the nonselective opioid antagonist naloxone.  We have also conducted longitudinal studies were animals were imaged over time to correlate changes in receptor binding with the development of negative affective states.  Analysis of these data are ongoing.

Studies in people who misuse heroin show that acute opioid withdrawal increases opioid craving and seeking behavior, and that the severity of withdrawal predicts the response to treatment.  We therefore have conducted microPET imaging in opioid-dependent rats during the acute phase of opioid withdrawal. Analysis of these studies are ongoing.



Cure Addiction Now

StrongMinds provides life-changing mental health services to women in Africa using innovative community-based group therapy.

According to the WHO, depression is the leading cause of disability worldwide, and is a major contributor to the global burden of disease. In Africa, an estimated 66M women have depression and 85% have no access to treatment. Since 2014, StrongMinds has treated over 200,000 individuals for depression symptoms, with 80% measuring as depression-free after therapy. When a woman recovers from depression, she is more engaged in the community and her economic activity increases. Her family eats more meals and her children go to school more often. When you invest in mental health, you invest in the future of an individual, their family, and their community.

StrongMinds Inc

Connecting scientists and public officials to improve the management of Global Catastrophic Risks in Latin America and Spain.

[Observatorio de Riesgos Catastróficos Globales (ORCG)](https://orcg.info) is a science diplomacy organization working to improve global risk management in Spanish-speaking countries. To achieve our mission, we connect decision makers with experts and produce evidence-based publications.Our team works together with experts and public officials to co-create policies that identify, prevent and mitigate the effects of global risk.

Our current focus areas include 1) Artificial Intelligence regulation, 2) food security against global catastrophic food failure, 3) Pandemic biosecurity in Latin America, and 4) improving global catastrophic risk management (all-hazards).

Your support will enable our research and advocacy efforts.

*Observatorio de Riesgos Catastróficos Globales is a project of Players Philanthropy Fund, Inc. a Texas nonprofit corporation recognized by IRS as a tax-exempt public charity under Section 501(c)(3) of the Internal Revenue Code (Federal Tax ID: 27-6601178, [ppf.org/pp](http://ppf.org/pp)). Contributions to Observatorio de Riesgos Catastróficos Globales qualify as tax-deductible to the fullest extent of the law.*

Observatorio de Riesgos Catastróficos Globales (RCG)

Peek Vision is a social enterprise that powers eye health programme providers to strengthen systems and service delivery. 

Peek Vision is a social enterprise.  The Peek Vision Foundation is a registered charity in the UK which wholly owns a not-for-profit company, Peek Vision Ltd.  Together, we are known as Peek Vision and we exist to bring better vision and eye health to everyone. 

**What we do:**

Peek's software and data intelligence platform powers our partners to optimise eye health screening and referral pathways so that no one is left behind. Together, we aim to make large-scale, sustainable improvements to health systems.  By 2050, we aim to prevent 1.25 billion people from needlessly losing their eyesight.

With Peek, eye health providers can identify gaps and inequalities in their services.  People who would have been invisible to health workers or hard to reach are made visible so that nobody is left behind.

**We offer partners:**

Population-level eye health surveys & tools to understand prevalence rates and aid programme design
Screening and data capture by anyone, anywhere, using a clinically validated vision screening app
Scalable programme design and continuous optimisation
Powerful software to monitor journeys to care to produce actionable insights
This approach enables our partners to design programmes with multiple stakeholders engaged and with a population-level approach, continuously improve their programmes and track patients’ journeys to care using our data intelligence platform.

Our research is published in peer-reviewed scientific journals, and rigorous evidence is at the heart of everything we do. All of our work is impact-driven, supported by a talented, multidisciplinary team. We are united by the belief that by working together, we can make the invisible, visible in eye health.

Peek Vision Foundation

Help us prevent, diagnose, and cure heart rhythm diseases, a leading cause of sudden cardiac arrest and death worldwide.

**Heart Rhythm Diseases: Over 50 million people affected worldwide**

Atrial fibrillation, sudden death, heart failure—these heart rhythm diseases, whether chronic or acute, and sometimes silent, can affect anyone at any age. They lead to serious complications and cause hundreds of thousands of deaths each year. Thanks to our research, improved screening for at-risk individuals and new treatments will help protect the health and lives of more patients in the future.Bringing together national and international expertise from many disciplines within a single institute, Liryc is committed to  advancing medicine and providing better care for patients with heart rhythm disorders. 

**Bringing innovative and personalized therapies to life:**

Liryc teams aim to develop innovative technologies for diagnosing and treating heart rhythm disorders. Liryc, through its unique multidisciplinary and international infrastructure, promotes collaboration between research teams, clinical teams and economic players, which enables the emergence of innovative projects to invent diagnostic tools, cutting-edge medical devices, and therapies of the future. 

**Why support Liryc?**

Heart rhythm disorders are responsible for 30% of cardiovascular diseases. These disorders—such as atrial fibrillation, ventricular fibrillation, and heart failure—stem from electrical failures in the heart and affect millions globally. Whether chronic, acute, or immediately fatal, these conditions do not discriminate by age and could affect anyone, including you or your loved ones. Heart rhythm disorders result in:

- 20% of all strokes worldwide,
- 325,000 sudden cardiac deaths annually in the United States, 90% of which are fatal,
- 1 million hospitalizations for heart failure each year in the United States.


**Donate to advance cardiology research**:

The devastating toll on lives makes finding solutions urgent. Your support allows us to combat heart rhythm disorders by improving prevention, treatments, and training for healthcare professionals. Donations help:

- Fund new research projects to better understand cardiac electrical disorders,
- Purchase state-of-the-art equipment to provide experts with the best technology available to drive medical innovation,
- Support education and training programs to spread knowledge to more healthcare centers worldwide, ensuring patients benefit from the latest advances in treatment.

As Professor Michel Haïssaguerre, Founder and Honorary President of Liryc, explains:
*"Sudden death causes as many deaths in France as breast, lung, and colon cancer combined—50,000 deaths per year, or one death every 10 minutes."*

Liryc Heart Rhythm Disease Institute

Whistler Adaptive Sports offers a full range of adaptive sports programs and a dynamic learning centre in Whistler, BC. Canada. 

For over 20 years, the Whistler Adaptive Sports Program Society has been removing barriers to adventure for people with disabilities and neurodiversity, offering a full range of adaptive sports programs and a dynamic learning centre in Whistler, BC. Canada. We currently operate in Squamish, Whistler, Pemberton and Mount Currie. We also serve locals from across B.C. and visitors from Canada and around the world. 
 
Whistler Adaptive is committed to introducing individuals with a disability to sport, recreation and therapeutic sport programming. Whistler Adaptive supports sport for life by breaking down the financial, physical and social barriers as well as creating skills that will lead to future employment within sport and beyond. Whistler Adaptive empowers individuals through access to one of the world's best mountain resorts, providing them with the environment, support and opportunity to become physically active and focus on their abilities rather than disabilities. Programs are accessible to both children and adults with cognitive and physical disabilities. 

Whistler Adaptive serves locals in its community and visitors from across Canada and around the globe. All activities are run in a safe and supportive environment, allowing athletes to learn at their own pace. We pride ourselves on being able to change lives through the innovative sports programs we offer and the help we provide. Whistler Adaptive paves the way by increasing knowledge of adaptive sports through training and coaching clinics and values the consistent support that we receive from our volunteers. We seek to remove barriers to adventure and learning by training athletes with a real sense of passion. OVER 20 YEARS, 18 SPORTS PROGRAMS AND GROWING… The Whistler Adaptive Sports Program Society has been in operation for over 20 years with a record 3,000+ lessons taught in 18 adaptive sports. Through generous donations, we allocate resources for equipment and volunteer training to work with a range of individuals and athletes. Alpine skiing and racing, snowboarding, Nordic skiing, hiking and trail riders, hand-cycling, biking, canoeing, kayaking, rowing, swimming, triathlons, running, yoga and gymnastics are all part of Whistler Adaptive programming and our philosophies on "Grassroots to the Podium" and "Sport for Life". How we do it...The people here at Whistler Adaptive feel that sport builds socialization, leadership skills, healthy growth and development for everyone, whether they have just acquired a disability or have been active all their lives. By providing access to a vast number of sports across the winter and summer seasons, we are opening doors to endless opportunities and creating new levels of independence for individuals with disabilities. 

Whistler Adaptive Sports Program Society

CHILA seeks to provide quality healthcare to our Q’eqchi communities while respecting their cultural practices and traditions.

What are you supporting when you support CHILA’s mission?

When you support CHILA’s mission, you are saving lives
When you support CHILA’s mission, you are alleviating suffering
When you support CHILA’s mission, you are making magic happen…

There is a magic in seeing someone smile because they finally found someone who is listening.  There is magic in the relief that is felt when you help someone feel better.  There is magic when you connect and engage and show someone that you understand.

CHILA is a non-profit health clinic in Chisec Guatemala and all of our services are offered free of charge to anyone who walks into our clinic.  We rely on supporters like you to help us provide the highest quality of care for the residents of Chisec and her surrounding regions and connect our patients to living healthier lives.

Your gift provides:
~Highest quality of primary medical care
~Medication and treatment for acute and chronic medical conditions such as diabetes and high blood pressure, etc.
~Diagnostic Tests such as blood tests, ultrasound, radiological exams, biopsies etc.
~Specialty Consults such as orthopedic, pediatric, oncology, surgical etc.
~Transportation to hospital and clinic visits in Coban (2 hours), Guatemala City (6-8 hours) and other locations
~Translator services in their Q'eqchi language
~Monthly Diabetes Clinic

And so much more….

Your support does more than just provide medical services for the community.  Through educational opportunities, healthcare professionals and ancillary personnel are trained by CHILA to continue to provide care to their community in conjunction with telemedicine support with Dr. Smith.  By growing opportunities for the the local community, your support helps to strengthen their healthcare structure from within and helps to encourage local independence.

Access to healthcare is so much more than an open clinic door.  It is access to clean water, access to education, women’s rights and gender equity, food security, addressing domestic violence, access to functioning roads, transportation systems.  The health of a person is reliant on so many factors that are happening in a culture and in a community.  Your support is helping CHILA address the many issues that continue to affect health outcomes and access to healthcare in the Chisec community.

COVID-19 response:

In March of 2020, CHILA just completed what would be, unknowingly,  the last annual dental and medical mission with Kindness in Action due to the pandemic.  2 weeks later, the COVID-19 pandemic was declared and the border was closed and just like that, our in-person clinics ceased operations for over a year.   Like all the countries in the world, COVID-19 hit the communities of poor and disenfranchised the hardest.  But the CHILA team of Chisec rised to the occasion.  The team immediately gathered all the reliable scientific information that was being presented and they were one of the first to organize educational videos on virus information and prevention, proper hand washing techniques, and self-care and mental health awareness during quarantine all in the Q’eqchi Maya language.  They organized seamstresses to mass produce masks for the community with proper distancing and mask wearing observed.  They put together and delivered PPE packs to the staff of the local Centro de Salud and delivered food parcels to those communities that were having hardships with food security.  Here is what your support is provided:

~Oxygen concentrator machines
~Oxygen delivery supplies such as masks, nasal cannulas, nebulizers
~Medications packs with Tylenol, steroids, cough medicine etc.
~Vaccination education and outreach with the local healthcare system
~PPE and disinfectant supplies



CHILA’s Mission:

~Provide high-quality primary care for the populations of rural Guatemala
~Strengthen and work with the existing community healthcare system
~Preserve Q'eqchi Maya traditions and incorporate traditional Maya herbal medicine as part of our treatment modality
~Strengthen the activities of the local Women's Groups as partners in healthcare access
~Provide all healthcare in the native Q’eqchi Maya language
~Deliver excellence in healthcare no matter the ability to pay

Our History and Our Present:

CHILA was started by Brian Smith, MD in the town of Chisec, Guatemala.  Brian served as a member of the Peace Corps in the region and witnessed firsthand the lack of access to healthcare for the population in the area.  Once he returned to the United States, he changed his vocation from engineering to medicine.  He entered medical school and became a physician while concurrently traveling back and forth to Chisec to build and open a medical clinic.  CHILA has grown with the belief that no person should die or be denied healthcare because of where you were born.  After years of providing care to many people in the region, CHILA was recognized as a nonprofit organization in 2019.

Currently, CHILA funds a small group of local medical professionals in Chisec who we pay to provide ongoing  and prescribed care for chronic and complex medical conditions.  Dr. Smith and a contingency of volunteer medical providers from the United States travels to Chisec several times a year to hold clinics in our Chisec location as well as a variety of villages in the region.  During these clinic days, we see cases of varying levels of complexity.  We are able to treat common ailments during these clinic days as well as establish longer term care plans for more complex and chronic issues.  We provide all these services with translators who can speak in the native Q’eqchi language.

Chila Inc

Providing low-income uninsured neighbors with free medical, dental, and mental health care as an expression of Jesus Christ's love

34,000 low-income uninsured neighbors in Idaho's Treasure Valley can't afford healthcare. 

Genesis Community Health is a 501(c)(3) nonprofit clinic providing them with free medical dental and mental health care as an expression of the love of Jesus Christ.

We are a grassroots organization supported by over 200 active volunteers as well as donors, businesses, churches, and foundations throughout the Treasure Valley.

Genesis Community Health

VillageReach transforms health care delivery to reach everyone. 

VillageReach transforms health care delivery to reach everyone, so each person has the health care they need to thrive. 

Last year, we increases the availability of quality health care for more than 58 million people across sub-Saharan Africa by increasing access to medicines and vaccines, improving the capacity of the health workforce and enabling better decision-making for patients, health workers and policy-makers.

VillageReach

MTF advances the knowledge and practice of massage therapy by supporting scientific research, education, and community service 

The Massage Therapy Foundation advances the knowledge and practice of massage therapy by supporting scientific research, education, and community service.  Guiding Principles   The Foundation commits to:  • Upholding the principles of philanthropy • Contributing to the understanding and appreciation of massage therapy. • Increasing the Foundation’s visibility in health and wellness. • Sustaining the Foundation’s organizational effectiveness. • Fostering the spirit of collaboration.  Goals  1. Advance research on therapeutic massage and bodywork  2. Foster massage therapy initiatives that serve populations in need   3. Promote research literacy and capacity in the profession  4. Support the evidence-informed practice of therapeutic massage and bodywork based upon available research, client factors, and practitioner experience and judgment  5. Fortify the Foundation’s resources and organizational effectiveness  History  The Massage Therapy Foundation was founded in 1990 with the mission of bringing the benefits of massage therapy to the broadest spectrum of society through the generation, dissemination, and application of knowledge in this field. We do this by receiving donations and granting funds for research, community service, educational initiatives, and conferences, as well as by providing resources to the medical and research communities, and by educating massage therapists about the world of research.

Massage Therapy Foundation

We want to help lead the fight against cancer.

The Cancer Association of South Africa (CANSA) is a leader in the fight against cancer since 1931. Our purpose is to lead the fight against cancer. Our mission is to be the preferred non-profit leader that enables research in lowering cancer risk, educating the public regarding symptoms, screening and risk reduction, and providing care and support to all those affected by cancer.


CANSA is committed to connecting people facing cancer with information, day-to-day help and much-needed emotional support. We aim to ensure that cancer survivors and their loved ones do not face cancer alone.


While we are not privy to medical diagnoses and the onus falls on the patient or their family (with their permission) to contact CANSA for assistance, we are here to support them through every step of their cancer journey.


Through the selfless support of our sponsors like yours, we can continue the fight against cancer in South Africa and advance closer to the goal of a cancer-free society in our generation.

OUR SERVICES
CANSA offers a wide range of services to those affected by cancer:
• Health Awareness Programmes - comprises health education campaigns centred on creating awareness of cancer symptoms, the importance of screening and lowering cancer risk.
• Mobile Health Clinics – bring awareness to men and women in rural areas who would otherwise not have access and operates on sponsored funds.
• Promote early detection - CANSA Care Centres countrywide offer screenings and early detection programmes.


CANSA ORGANISATIONAL PROFILE
• CANSA Care Centres - offer care and support services to those affected by cancer, including employee wellness programmes, stoma support, wigs, prostheses, assistive devices and medical equipment hire, clinical support, counselling (face-to-face and Tele Counselling), support groups and home-based care.
• CANSA Care Homes – provide patient care and support to the main metropolitan areas for out-of-town cancer patients undergoing treatment.
• CANSA TLC Lodging – provides lodging and support services for parents and guardians of children undergoing cancer treatment.
• CANSA Help Desk - Toll free 0800 22 66 22.
• WhatsApp helplines – offer multilingual support services in English, Afrikaans, isiXhosa, isiZulu, Sesotho and Siswati.
• Online support groups and platforms – help patients and loved one’s cope with a cancer diagnosis or connect with others walking a similar path as they fight cancer.
• Social media platforms and CANSA Website – make information available to the public.
• CANSA Tele-Counselling – offers a confidential, professional, cancer-related telephonic counselling service to cancer patients, caregivers and their families, and parents or guardians of children living with cancer. This service is free of charge and available in seven languages - English, Afrikaans, isiXhosa, isiZulu, siSwati, Sesotho and Setswana.


CANSA VOLUNTEERS
CANSA is a volunteer-driven organisation, relying on our trained volunteers to assist in delivering our services to local communities across South Africa. We have various volunteer opportunities and trainings available.


CANSA IS COMMITTED TO SUPPORTING THE GLOBAL UNITED NATIONS SUSTAINABLE DEVELOPMENT GOALS (SDGs)
The Sustainable Development Goals or Global Goals are a collection of 17 interlinked goals designed to be a ‘blueprint for achieving a better and more sustainable future for all". The SDGs were introduced in 2015 by the United Nations General Assembly and are intended to be achieved by 2030. CANSA strives toward achieving these goals within our capabilities.


We have identified the Global Goals (SDGs) CANSA has contributed to, in some capacity, during the reporting period with an emphasis on Goals 3 (Good health and wellbeing), 4 (Quality Education), 5 (Gender Equality), 7 (Affordable and clean energy),  8 (Decent Work and economic growth), 9 (Industry innovation and infrastructure), 10 (Reduced inequalities), 11 (Sustainable cities and communities), 12 (Responsible consumption and production), 13 (Climate action), 14 (Life below water), 15 (Life on land), 16 (Peace, justice and strong institutions), and 17 (Partnership for the goals).

CANCER SCREENINGS (Stats 2020/21)
• Over 54 210 conducted in total (with abnormalities referred accordingly).
• Conducted over 6 260 pap smears and facilitated 2 989 in partnership with the Department of Health (DoH).
• Carried out more than 20 570 clinical breast examinations.
• 8 848 Prostate Specific Antigen (PSA) tests completed and 351 done in partnership with DoH.
• Over 3 010 skin examinations using the FotoFinder Mole Analysis device took place.
• Expanded workplace screening and wellness programmes.


HEALTH SCREENING, EDUCATION AND AWARENESS (Stats 2020/21)
• Approximately 40 727 individual information and education sessions conducted with screenings.
• Over 7 560 people assessed to determine their lifestyle risk, with 2 361 glucose tests performed for diabetes.
• More than 465 900 people reached through 1 738 talks and 4 531 exhibitions with the help of 795 health promotion volunteers.
• Over 150 radio talks hosted for cancer education.
• Distributed over 71 110 information leaflets to promote health awareness campaigns.


CANSA ORGANISATIONAL PROFILE
• More than 79 700 youth reached through 402 school programmes.
• Our CANSA Helpdesk responded to over 12 680 enquiries for support and information via telephone, WhatsApp, email, website and social media.


CURRENT PLANS AND THE FUTURE
CANSA’s service and income generation is managed and deployed centrally with national teams, placed across the country. We streamline and modernise our service and fundraising efforts regularly. We have CANSA Care Centres around the country with certain CANSA Care Centres operating as ‘Virtual CANSA Care Centres’ where employees work remotely to offer services within their surrounding communities assisted by willing volunteers.


Our country’s economic recovery post COVID-19 will take a few years. The need for our normal services continues and even more patients and caregivers need help. We are aware of our duty to continue to educate South Africa about the cancer burden and find innovative ways to help lower the cancer risk, while providing support and care to the communities we serve.

Cancer Association of South Africa (CANSA)

The world's-first funding vehicle to collectively grow our resources to support the long-term flourishing of humanity. 


Join this first-of-its-kind philanthropic fund designed for the long-term future. Our Patient Philanthropy Fund addresses a crucial gap: humans spend too little on protecting and benefiting our future generations. However, we can positively affect the lives of our descendants, and avoid major catastrophes that could destroy their future.
 
Contributions are invested for long-term gains, initially in a low-fee Global Stock Index Fund. When a critical time, need, or opportunity arises, we step in to make a grant. Taking a patient approach allows us to wait for a point in time when the highest-impact opportunities are available, which may be years, decades, or even centuries ahead.

### Our Approach to Grantmaking
We're not designed to be a frequent grantmaker; we are primarily an investment account until we reach an extraordinary time and opportunity. Until those moments arise, each year we will make small grants at less than 1% of the Fund's size to the best available opportunities we are able to find in that year. These small grants will build up our grant-making infrastructure and track record. Grant decisions will be made by a dedicated management committee, all with a strong network and expertise on how well-timed grant-making can safeguard the future.

### Frequently-Asked Questions
**Can charities apply for money from the Fund?**
The Funds do not generally accept applications from charities, and we request that charities do not send unsolicited applications for funding. If the Fund Managers choose to open up an application round, this will be publicized. 

### More Questions? 

To learn more about the Founders Pledge Patient Philanthropy Fund, please visit [www.founderspledge.com](https://www.founderspledge.com/funds/patient-philanthropy-fund) or email the Fund Managers at funds@founderspledge.com.

Founders Pledge: Patient Philanthropy Fund

Not for profit, founded as a 501C3 charity in 2006 in NYC. Providing Health, Education, and Empowerment opportunities.

Our cornerstone project was building East & Central Africa's 1st Public Children's Hospital.  Since opening in 2015, we have treated over 1.2 million kids. The impact does not end there, we have also constructed six public (free-to-attend) schools, a dairy project, a community house and more. We also run a vibrant Women's Empowerment Project focusing on agri-biz and domestic violence survivors.  Our latest major project is constructing the first children's cancer hospital in sub-Saharan Africa.

visit our Learn About Us page on shoe4africa.org

Shoe4Africa

We enable working professionals to maximize their positive impact by supporting them in donating their various resources.

We empower working professionals to have the biggest positive impact possible. We are building a community of professionals working together for the greater good, contributing not only through their money but also with their time and skills according to the principles of effective altruism.

High Impact Professionals is a project of Charity Entrepreneurship operating through a fiscal sponsorship with Players Philanthropy Fund (Federal Tax ID: 27-6601178), a Maryland charitable trust with federal tax-exempt status as a public charity under Section 501(c)(3) of the Internal Revenue Code. Contributions to High Impact Professionals are tax-deductible to the fullest extent of the law.

High Impact Professionals

Providing affordable, quality, medical, dental, mental health & pharmacy services through our 5 Los Angeles locations since 1967. 

We’ve come a long way since we opened our doors as the Los Angeles Free Clinic in the Summer of Love, 1967. From a single storefront on Fairfax Avenue, we are now the Saban Community Clinic, with four health centers and one satellite site providing comprehensive medical, behavioral health and dental care plus access to social services.

While a lot has changed over the past 50 years, our founding belief remains the same: that healthcare is a right, not a privilege. The integrated and holistic approach to treating the entire individual, which we pioneered five decades ago, is practiced today as Whole Person Care.

Saban Community Clinic

Water is a human right and a vital necessity.

Help people access safe and clean water.  
 
Almost a billion human beings in the world lack basic access to clean, safe drinking water. Autour de l'Eau's mission is to assist people in rural Cameroon build and maintain sustainable, efficient water systems.  In addition to financing and organizing the physical construction of these systems, we work closely with our local partners to ensure that our projects meet their economic, social, and cultural needs. Over the past eleven years, Autour de L'Eau has facilitated the construction of numerous sanitary toilets and mechanized water pumps in the city of Kribi. Having already built a water tower in Grand Batanga, our current focus is on completing a new water distribution system that will bring drinking water into the homes of four thousand people. Access to safe water leads to positive and sustainable change in terms of health, education, higher literacy rates and quality of life. Please join us in helping people in Cameroon enjoy the benefits of purified, safe water for drinking and sanitation.  The American Friends of About Water In Africa is a branch of the French nongovernmental organization, Autour de l'Eau. Check out our Facebook  page. 
 
Increase access to water.  
 
Contribute to the American Friends of Autour de l'Eau  via credit card. For gifts by check:  Write your check to KBFUS, write "Autour de l'Eau " in the memo section of the check, and send it to KBFUS, 551 Fifth Avenue, Suite 2400, New York, NY 10176 . Gifts by wire transfer or to contribute other types of property:  Email KBFUS at: info@kbfus.org or phone (212) 713 7660.

About Water in Africa (Autour de l'Eau) 

Hood Medicine is a nonprofit public health collective dedicated to protecting black and brown lives during the pandemic & beyond.

We focus on health equity, public health communications, and combating health-related dis/misinformation in BIPOC communities to serve our primary mission of using science and technology to improve health outcomes for historically marginalized communities, empower families to make healthy choices & help them find trusted healthcare & vital resources. 

We have research collaborators across industry and academia working with us to understand how health misinformation affects intersectional patient populations and evaluate interventional strategies for public health advocacy at the grassroots level.

We provide vaccine education and promotion to various civic & health organizations using our culturally tailored public health communications framework to develop equity-focused messaging targeting intersectional BIPOC communities.

Hood Medicine Initiative Inc

Support So They Can to ensure that no girl is left behind. To receive a tax receipt for NZ or AU, please donate via sotheycan.org

Every child deserves access to education. It is a basic human right. Yet in Sub-Saharan Africa, over one fifth of primary school aged children are not in school. That’s just not right. 

So They Can is an international NGO on a mission to change this. They work with vulnerable communities and their governments in Kenya and Tanzania to educate and empower children, so they can break the poverty cycle, realise their own potential and meet their own needs. 

Over a 7-10 year development cycle, So They Can works closely with a community to understand their needs and implement projects that will best support them. Throughout the cycle, they develop relationships and ensure transfer of knowledge and management skills to these communities to ensure sustainability of the programs. This enables them to eventually shift to a governance role so we can expand our focus and core resources to help other vulnerable communities.

Since being founded in 2008, the DFAT accredited NGO has partnered with 42 schools and helped deliver quality education to over 24,000 students.

Visit www.sotheycan.org find out more about So They Can's projects, the impact they make and how you could get involved.

Upcoming online event

Join So They Can for one hour on Sunday 26th June (San Francisco time) to learn how you can make a real, life-changing difference to a child's life in East Africa.

Meet our Founder, Cassandra Treadwell, to discover how our work began over a decade ago, and the incredible impact we're having together as a global organisation today.

Enjoy a livestream to Kenya and say hello to some of the children our amazing Sponsor and Donor Community empower through education in East Africa. Hear from the students and discover how through our Student Sponsorship Program, their lives and their families' lives have changed for the better.

Who is this event for?
- People who are interested in joining our community and making a difference through Sponsorship
- Existing supporters and sponsors who want to feel connected to the impact their support is having in East Africa
- Individuals and businesses who are new to So They Can and want to learn more about our education and empowerment work

Event times for our supporters around the world...
San Francisco: Sunday 9pm, Sunday 26th June
Australia: 2pm AEST, Monday 27th June
New Zealand 4pm, Monday 27th June
Kenya: 7am, Monday 27th June
London: 5am, Monday 27th June
Singapore: 12pm, Monday 27th June

Sponsorship is life changing, for the student and for the sponsor. We would love for you to walk away with the inspiration and commitment of joining our global community of student sponsors. 


So They Can

Further Health helps you advance amazing biomedical research that are reshaping how people live healthier for longer.

Further Health focuses on advancing the most incredible biomedical research efforts that make it possible for people to enjoy healthier lives for longer.

Your donations help our team expand public awareness and advance scientific understanding on how to prevent and reverse diseases, injuries, and disorders using next-generation treatments.

Further Health, Inc.

Founders Pledge is a global nonprofit empowering entrepreneurs to do the most good possible with their charitable giving. 

We equip members with everything needed to maximize their impact, from evidence-led research and advice on the world’s most pressing problems, to comprehensive infrastructure for global grant-making, alongside opportunities to learn and connect. We’re grateful to be funded by our members and other generous donors. 

Founders Pledge

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We are a nonprofit, so instead of charging fees we rely on the generosity of donors like you.