High quality medical services for marginalized groups in Cairo and the region.

Mersal Foundation for Charity and Development is a non-profit organization that serves in the health field and works on providing all types of healthcare with high quality to whoever is in need.

**Vision**
To be the number one medical organization in Egypt and the Arab region and proactive in ensuring the right in healthcare for the marginalized groups and those who are in need the most.

**Message**
Working on analyzing and filling the gaps of the healthcare system to provide high quality medical services on the basis of equality and dignity through enabling a charitable healthcare system for whoever cannot afford it, as well as contributing to the development of the health sector.

**Objectives**  

- Providing medical services to whoever deserves them regardless the cost or for how long they will be needed.
- Spreading medical awareness in all the places it serves in.
- Achieving sustainability in funding its activities Core Values.
- Privacy: Mersal ensures the patient's eligibility to receive its services without hurting their dignity or exposing them to any kind of embarrassment.
- Healthcare With No Discrimination: Mersal is an open arm to all patients with no discrimination whatsover; whatever religion, nationality, color, or language, all patients in need are welcomed to receive the organization services.
- High Quality: Mersal provides all types of medical services in the highest possible quality through its network of specialized medical personnel.
- Credibility and Transparency: Mersal announces the size and sources of its fund as well as its administrative and medical expenditures, The foundation financial reports and annual budgets are available through several outlets through which any person can explore how resources are managed. Mersal believes in the importance of being specialized in specific fields and its early choice was the healthcare services.

In the past six years, the organization registered over 25,000 patients from 27 provinces.  Mersal has been seeking to enable access to its services all over the country. And the dream of helping those who are in need whoever they are and whatever the cost and time is still alive, Mersal has worked over the past six years on getting close to its patients throughout their treatment journey.

Mersal Foundation for Charity and Development 

We are a research hospital that treats patients in all medical disciplines, focusing on oncology, neurology, and diagnosis.

The Fondazione Casa Sollievo della Sofferenza – Opera di San Pio da Pietrelcina (transl. Home for the Relief of Suffering Foundation – Work of Saint Pio of Pietrelcina) is a not-for-profit research hospital located in the city of San Giovanni Rotondo (FG), in the Puglia Region, Southern Italy.
As per Canon 1303 §1 of the Code of Canon Law, it has public, canonical and civil legal personality; it is therefore subject to the supervision of the Holy See and, on its behalf, of the pro-tempore Cardinal Secretary of State. 
Many of the stages that have thus far marked the history of the Work of San Pio of Pietrelcina have been achieved thanks to the loving generosity of many benefactors who, sharing the mission indicated by San Pio da Pietrelcina, the relief of suffering, wanted to donate to his work.

HISTORY
The hospital was founded and inaugurated by Saint Pio of Pietrelcina on May 5, 1956 with a capacity of 250 beds. It took on the status of Provincial Hospital on 4 August 1971 and then of Regional General Hospital on 2 June 1980, thus becoming part of the Italian National Healthcare System. Since 16 July 1991, with a Decree of the Minister of Health and the Minister of University and Scientific Research, it has been a Research Hospital. Originally, the object of its scientific activity was limited to genetic and hereditary-familial diseases; subsequently, the Minister of Health, by the 5 December 2012 Decree, extended the research areas of its competence to "Genetic diseases, innovative therapies and regenerative medicine". Recently, on the occasion of the presentation of the research lines for the three-year programme of the Italian Research Hospitals 2022-2024, Casa Sollievo identified “Diagnostic acitivity, Neurology and Oncology” as its main research thematic areas, thus becoming a polythematic Research Hospital.

MISSION
The Foundation's mission is to provide health care and carry out research activities. In addition, the Foundation offers training activities for its personnel.
Around 2,750 people work at the Foundation.
The Foundation (hereinafter “CSS”) consists of three structures based in San Giovanni Rotondo: the hospital Casa Sollievo, the polyclinic Giovanni Paolo II, where outpatient activities are carried out, and the ISBReMIT research center for regenerative medicine (Institute for Stem-cell Biology, Regenerative Medicine and Innovative Therapies); and the Mendel Institute in Rome, where research and diagnostic activities are carried out. In San Giovanni Rotondo, it also owns and runs a retirement home for the elderly.
In addition, CSS owns 3 hospitality facilities where affordable accommodation is offered to hospitalized patients’ relatives who have to assist them; and another facility (Casa Zeni) where accommodation is offered free of charge to the parents of the little patients hospitalized in the oncology-hematology unit.
Moreover, the Foundation includes the Padre Pio Prayer Groups Centre, which was also founded by San Pio and coordinates the Padre Pio prayers groups throughout the world, according to the Founder’s wish that Prayers Groups live and testify the importance of prayer and pray for CSS.
Lastly, CSS publishes a monthly periodical and posts on the Foundation’s official channels on the web updates on its research and clinical activity and its spiritual activity and the teachings of the Founder.
The hospital offers assistance also to people from underdeveloped countries. 
Moreover, a free-of-charge shuttle service has been provided for many years to radiotherapy patients coming from Bari and surrounding cities (Southern Puglia).

THE CLINICAL ACTIVITY
CSS has around 756 beds, 38 medical and surgical inpatient units, 26 operating rooms, in addition to services, diagnostic and multi-specialist outpatient units.
In 2022, the hospital recorded over 30,000 hospitalizations and 870,000 outpatient performances. 
Regarding the advanced technological equipment, CSS has 1 "Da Vinci" surgical robot, 1 PET/CT device, 3 linear accelerators, 4 CT devices, 1 CT simulator for radiotherapy, 4 NMR equipment, 3 digital angiographs, 2 gamma cameras and a RIS/PACS system for the filmless management of the radiology department.
Furthermore, CSS hosts an Umbilical Cord Bank and a Human Milk Bank.
Recent Achievements
In addition to the many important activities carried out in CSS, 3 new units have been opened: 1. a new Emergency Room hosting an Observation and Assessment Ward; 2. an Hematopoietic Stem Cell Transplant Center. 3. an Sub-Intensive Geriatric Unit. 
CSS has also established a Stroke Unit, a Lung Unit, a Breast Unit, a Head and Neck Unit, and a Molecular Tumor Board to guarantee appropriate, quality and homogeneous procedures.
Future goals
Important technological investments have been planned for the years 2023-2025 in the following areas: oncology/nuclear medicine, diagnostic imaging, ICU, and surgery. 

THE RESEARCH ACTIVITY
The research activity is conducted in the Polyclinic, the ISBReMIT research center and at the Mendel Institute, for a total of 17 research groups.
Recent achievements
The consolidated experience of the staff working in CSS in the study of genetic diseases since 1991 and the continuous updating of technologies, instrumentation and genomics and post-genomics skills have made it possible to direct the research and clinical-assistance activity towards two complementary research lines: "personalized medicine - system biomedicine" and "regenerative medicine" based on the study of tumor stem cells and the use of normal stem cells.
The scientific fields in which the Institute is mostly involved in "personalized medicine" concern the identification of the genetic causes of rare diseases and the identification of diagnostic, prognostic and predictive markers in complex pathologies, including tumor pathologies. Regarding the identification of the genetic causes of rare diseases, we use the new next generation sequencing (NGS) technologies and the skills acquired by the bioinformatics unit, one of the first established at national level. In parallel, the Institute boasts a large collection of induced pluripotent stem cells (iPSCs), produced from patient fibroblasts, in which pathogenetic variants have been identified, and use the skills acquired in differentiating them into mature cells, in particular astrocytes, neurons and oligodendrocytes.
Regarding regenerative medicine, two important studies were conducted and concluded: a phase I trial on anti-Multiple Sclerosis therapy based on the use of human neural stem cells, approved by the Ministry of Health and the Italian Medicines Authority AIFA (EudraCT code 2015-004855-37); and a phase I/II trial on anti-glioma therapy with biological drugs (EudraCT code: 2016-001761-92). The results of these studies will published in prestigious international journals.
In 2015, the new ISBReMIT Regenerative Medicine Research Center was started. It is a cutting-edge structure in terms of conception and equipment in the field of translational medicine for genetic, degenerative and oncological diseases. The structure hosts, together with the highly technologically equipped laboratories, a cell factory and a laboratory for the production of biopharmaceuticals under Good Manufacturing Practice, i.e. for clinical use, including somatic stem cells and iPS, vectors for gene therapy and biomaterials.
It should be noted that CSS has recently become part of three Networks of the Italian Research Centers: since 2016 it has been an Ordinary Associate of Alleanza Contro il Cancro; since December 2018, of the National Research Network on Aging; and, finally, since March 2020 of the Neuroscience Network. Starting from 2022, CSS has been part of the European reference networks for rare and uncommon diseases (European Reference Networks - ERN), in particular ERN-SKIN on diseases of dermatological interest, and ERN ReCONNET on musculoskeletal diseases and pathologies of the connective tissue.
Researchers publish about 200 scientific articles in the most renowned journals (Science, New England Journal of Medicine, Nature Genetics) every year. They are engaged both as Principal Investigators and as partners in research projects in the biomedical field and ICT, obtaining funds from the EU (H2020 and FP7) and national or regional calls.
CSS is also a partner in Research and Innovation projects funded by private and public bodies, e.g. from the EU both under Horizon 2020 and Horizon Europe, in the field of digital transformation of healthcare. The main areas of involvement concern Assistive Robotics, Artificial Intelligence, Big Data generated by consumer devices, eHealth, Digital Therapies, the Internet of Things and Cybersecurity.
Future goals
Starting from the identification of the genetic causes of diseases, the goal is to develop advanced therapies to bring to the patient's bedside and tailored to him/her.
Furthermore, at the end of 2023, the phase II study "Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis: A multicenter, randomized placebo controlled and biological endpoints clinical Trial" (EudraCt 2018-002373-22) will be launched. This involves the use of neural stem cells on patients suffering from Amyotrophic Lateral Sclerosis.

CONCLUSION
Casa Sollievo della Sofferenza was born of the visionary mind of a poor friar, one of the most important, recent and internationally recognized and prayed Saints, Saint Pio of Pietrelcina, right after the II World War, in a poor corner of the Southern Italy of those times. 
CSS, by its Statutes, is a not-for-profit organization. All the good work that has been done until now for the sick has been possible thanks to the generosity of donors and to the public and private funds that have been collected through the hard work of the Foundation’s researchers and clinicians, thus contributing importantly to the care of citizens from Southern Italy and underdeveloped countries and to the world research.

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza - Opera di San Pio da Pietrelcina

We provide cash incentives for childhood vaccinations. It’s one of the most cost-effective ways known to save lives.


New Incentives’ mission is to save lives in a way that does the **most good per dollar**.
Guided by evidence, we provide cash incentives to increase childhood vaccination rates.

- We [raise awareness](https://www.newincentives.org/blog-posts/awareness-activities) about the benefits of childhood vaccinations.
- We [provide cash incentives](https://www.newincentives.org/blog-posts/a-day-in-the-life-abubakar-aliyu-field-officer) at government clinics after children receive vaccinations.
- We [help improve the vaccine supply chain](https://www.newincentives.org/blog-posts/supporting-government-partners-with-vaccine-supply-efforts) to ensure enough vaccines are available at clinics.

Together, these efforts are proven to double vaccination rates and save lives.
Learn more about the [randomized controlled trial](https://www.newincentives.org/rct-results).

As of March 2024, New Incentives has reached more the 3 million infants in northern Nigeria.

New Incentives

ConnectMyVariant's mission is to end hereditary disease by bringing families together.

ConnectMyVariant is an educational health-focused 501(c)3 nonprofit organization that supports individuals and families with hereditary disease in their early detection and prevention efforts. We provide unique value by leveraging our evidenced-based family connection protocols to help people identify other at-risk relatives and help those relatives access genetic testing so that they can get optimal medical care. ConnectMyVariant brings people with the same genetic risk together through our variant database and community engagement events to share experiences and find common ancestors. ConnectMyVariant also works to increase awareness of the benefits of family outreach among physicians, others who provide prevention care, and the broader genealogy community.
 
Our key activities are:
   - Working with patients to implement personalized family outreach plans
   - Interactive educational workshops about sharing information on inherited disease risk
   - Variant specific family reunions to share stories and plan outreach to cousins
   - Genealogy assistance to help connect individuals in variant groups
   - Individual equity and inclusion grants for family and community outreach

Need and Impact:
When hereditary disease risk is known, family outreach has been proven to be the most effective and cost-effective intervention for early detection and prevention. This family outreach, also known as cascade testing, is recommended by multiple guidelines. Despite overwhelming evidence, family outreach assistance is not reimbursed by insurance or integrated into healthcare. Many people suffer and die from hereditary disease that could have been prevented or caught early.
 
We have shown that our strategies to encourage family outreach can act as a communication multiplier. Our pilot research at the University of Washington showed that this approach enhanced patient experience, was considered ethical, and was appreciated by newly identified relatives. Our approach is low-cost and is 25 to 50 times more effective than awareness and education interventions that target the general population.

Equity and Inclusion:
ConnectMyVariant is committed to being a leader for equity, diversity, and inclusion in hereditary disease prevention. ConnectMyVariant’s goal is to spread awareness among all individuals and families about inherited disease risk. All project staff, participants, and partners in ConnectMyVariant have an equal voice in developing innovative ways to improve hereditary disease outreach and prevention for all people. By fostering a diverse and inclusive community, we can provide knowledge and opportunities that have been historically inaccessible to millions of people.

ConnectMyVariant

VillageReach transforms health care delivery to reach everyone. 

VillageReach transforms health care delivery to reach everyone, so each person has the health care they need to thrive. 

Last year, we increases the availability of quality health care for more than 58 million people across sub-Saharan Africa by increasing access to medicines and vaccines, improving the capacity of the health workforce and enabling better decision-making for patients, health workers and policy-makers.

VillageReach

One of GiveWell's top charities for the past several years, AMF provides anti-malarial bednets to people in need. 

From Givewell: 
What do they do? AMF (againstmalaria.com) provides funding for long-lasting insecticide-treated net (LLIN) distributions (for protection against malaria) in developing countries. (More)

Does it work? There is strong evidence that distributing LLINs reduces child mortality and malaria cases. AMF conducts post-distribution surveys of completed distributions to determine whether LLINs have reached their intended destinations and how long they remain in good condition. AMF's post-distribution surveys have generally found positive results but have some methodological limitations. (More)

What do you get for your dollar? We estimate that the cost to purchase and distribute an AMF-funded net is $4.95, or $4.65 excluding in-kind contributions from governments. The numbers of deaths averted and other benefits of distributing LLINs are a function of a number of difficult-to-estimate factors, which we discuss in detail below. (More)

Is there room for more funding? We believe that AMF is likely to be constrained by funding. We estimate that AMF could use up to an additional $37.8 million to support LLIN distributions that will occur between now and late 2023. 

AMF is recommended because of its:

Focus on a program with excellent evidence of effectiveness and cost-effectiveness.
Processes for ensuring that nets reach their intended recipients and monitoring whether they remain in homes and in good condition over the long-term.
Room for more funding – we believe AMF will be able to use additional funds to deliver additional nets.
Transparency – AMF shares significant information about its work with us and we are able to closely follow and understand its work.

The Against Malaria Foundation

StrongMinds provides life-changing mental health services to women in Africa using innovative community-based group therapy.

According to the WHO, depression is the leading cause of disability worldwide, and is a major contributor to the global burden of disease. In Africa, an estimated 66M women have depression and 85% have no access to treatment. Since 2014, StrongMinds has treated over 200,000 individuals for depression symptoms, with 80% measuring as depression-free after therapy. When a woman recovers from depression, she is more engaged in the community and her economic activity increases. Her family eats more meals and her children go to school more often. When you invest in mental health, you invest in the future of an individual, their family, and their community.

StrongMinds Inc

Prevention, control and treatment of malaria and other communicable diseases  among vulnerable populations.

Our mission is to improve lives in Africa and Asia through sustainable, evidence-based programs  that combat targeted diseases and promote child and maternal health. 

We will accomplish this together with partners and all levels of government, by:

designing and implementing cutting edge research, surveillance and monitoring and evaluation;
selectively scaling up and delivering sustainable evidence-based health programmes;
providing technical assistance and consulting services that shape and strengthen national and international health policies, strategies and systems and build local capacity;
seeking to ensure that our experience, thought leadership, practical findings and research results are effectively communicated and contribute to the coordinated improvement of access to and quality of healthcare. 
Our areas of expertise include: 
disease prevention, diagnosis and treatment
disease control and elimination
health systems strengthening
research, monitoring and evaluation leading to best practice
behavior  change communication
national and international advocacy, and policy development


Malaria Consortium

Odylia Therapeutics is a nonprofit biotech working to accelerate the development of treatments for people with rare diseases.

At Odylia, we accelerate therapeutic development for people with rare diseases, changing the way treatments are brought from the lab to the clinic. We strive to bring life altering treatments to people with genetic disease regardless of prevalence or commercial interest. 
Odylia is shifting the paradigm to focus on proven science and removing traditional roadblocks. We work to lower costs, reduce development time, focus research, and continuously drive successful programs towards clinical trials and regulatory approval. Strategic collaborations with patient groups, research labs, and commercial partners facilitate our work to ensure treatments are safe, effective, and ultimately reach patients who need them.

Odylia challenges the traditional approach to drug development through:

1. Lower cost of development
Lower licensing fees to decrease development costs and ensure continued commitment to program success

2. Increase speed of development
Challenge traditional approaches through regulatory engagement

Streamline development through strategic partnerships and a platform approach to drug development

3. Enable the entire ecosystem
Provide expertise through in-house Brydge Solutions and leveraging the Odylia Board

Enable the entire ecosystem through Initiatives that impact the broader field

Odylia Therapeutics

Will you help to support life-saving healthcare for Palestinians?

To provide immediate medical aid to Palestinians in need  
 
 Medical Aid for Palestinians (MAP) works for the health and dignity of Palestinians living under occupation and as refugees. We provide immediate medical aid to those in great need, while also developing local capacity and skills to ensure the long-term development of the Palestinian healthcare system.   For over 30 years, Medical Aid for Palestinians (MAP) has been reaching out to Palestinian communities, striving to deliver health and medical care to those worst affected by conflict, occupation and displacement.  MAP's vision is a future where all Palestinians can access an effective, sustainable and locally-led system of healthcare and the full realisation of their rights to health and dignity.   Through our offices in the West Bank, Gaza, East Jerusalem, Lebanon and London, we work with trusted and experienced local partners to achieve this vision. Our programmes provide access to essential health services and build local knowledge and skills to address local health problems. In times of humanitarian emergency, we are ready to respond rapidly with aid and assistance. MAP is also committed to bearing witness to the injustices caused by occupation, displacement and conflict. We speak out in the UK and internationally to ensure the political and social barriers to Palestinian health and dignity are addressed.

Medical Aid for Palestinians

The Magdi Yacoub Heart Foundation provides free, world-class medical services to the less privileged in Egypt.

The Magdi Yacoub Heart Foundation (Egypt) provides free, world-class medical services to the less privileged in Egypt and throughout the region, in the field of cardiovascular diseases. It was founded in 2008 by world renowned surgeon Magdi Yacoub, along with Nobel Prize Laureate Ahmed Zewail and Ambassador Mohamed Shaker. 

Magdi Yacoub Heart Foundation 

Helen Keller, our co-founder, envisioned a world without barriers to human potential. We are continuing her work.


Helen Keller, our co-founder, envisioned a world without barriers to human potential. Guided by her fierce optimism, we have been working on the front lines of health and well-being for more than 100 years. We deliver life-changing health care to vulnerable families in places where the need is great, but access is limited. Our proven, science-based programs empower people to create opportunities in their own lives.


Helen Keller International

Protecting sight and fighting for disability rights

Sightsavers works in more than 30 countries worldwide, focusing on Africa and Asia.
We work with local, regional, national and international partners and governments. With their help, we distribute treatments to prevent disease, carry out eye operations, advocate for disability rights and improve health services to create sustainable development projects. 

Our vision is of a world where avoidable blindness is eliminated, and people with disabilities have the same rights as everyone else. We can only get there thanks to the generosity of our supporters, so we aim to be as transparent as possible so you can be sure your money is being used wisely.

Sightsavers

The Voice of Rare Disease Patients in Europe

EURORDIS is a patient-driven, non-governmental alliance of patient organisations and people living with a rare disease, representing 989 rare disease patient organisations in 74 countries, covering over 4,000 rare diseases. EURORDIS is the voice of 30 million people affected by rare diseases throughout Europe. 

EURORDIS - European Organization for Rare Diseases 

Fighting to overcome the challenges of living with epilepsy, accelerating therapies to stop seizures, find cures, and save lives.

For more than five decades, the Epilepsy Foundation has shone a light on epilepsy. The Foundation and its nationwide network of nearly 50 partners connects people to treatment, support and resources; leads advocacy efforts; funds innovative research and the training of specialists; and educates the public about epilepsy and seizure first aid.

Our local network provides direct services and connections in communities across the United States for individuals and families impacted by seizures and epilepsy. Each local foundation provides education and outreach to community organizations like school systems, emergency services, and local governments.

We provide educational support for individuals and families to help make sure they can manage and control their seizures to the best of their ability. Special initiatives help individuals and caregivers improve their overall health and raise awareness about the risk of sudden unexpected death in epilepsy (SUDEP). In addition, we educate the general public to help improve understanding of epilepsy, seizure recognition, and first aid. Epilepsy.com is the largest online education and community portal in the world for epilepsy education and awareness, with over 19 million global visitors a year.

Epilepsy Foundation



This is about bringing permanent changes to healthcare safety and quality! 

Mission Statement- 
National Nurses March, we value peaceful lifting of our nurse
voices united on a national level in an effort to be heard that
will promote change nationally for nurses for fair realistic
wages; including no caps, safe staffing, no violence against
healthcare workers, and changing the culture of the biases and
discriminations in the nursing profession.

National Nurses March

Save lives and donate to the world's most effective charities!

## Our Goal

High Impact Professionals' mission is to help professionals do the most good possible with their resources.  We created this drive to spread the word about effective giving and raise funds for some of the most impactful charities in the world.  

All 4 charities on this page are recommended as top charities by GiveWell, the world's most rigorous charity evaluator, and are estimated to be **100 to 1,000 times more effective** than an average charity.  

## Mechanics

Your donation will be **evenly split** between all 4 of these highly effective nonprofits. Your donation is made to Every.org, and Every.org then grants to these organizations.  

After donating, if you leave the option to share your email address with every.org checked, you will receive a link via email to redeem a copy of Doing Good Better for free from Amazon.

Thank you for your support!

Effective Giving for Global Health

Funding research with the highest probability of preventing, slowing, or reversing Alzheimer’s disease

Alzheimer’s disease was discovered over 110 years ago. Little was known about the disease and, since then, little more has been learned, until recently.

Frustrated with the slow pace of research about the disease, our founders applied their experience in venture capital and corporate startups to build an organization specifically designed to accelerate research, make bold bets, and eradicate the disease. They also insisted on four key principles to ensure success:

- Fund the world’s leading Alzheimer’s researchers
- Provide rapid review and approvals for submitted grants
- Insist on collaboration among funded scientists
- The board of directors pays for all overhead expenses so that 100% of donations go directly to research

Since our founding in 2004, our unwavering focus has been providing research grants to the worlds’ leading scientists researching Alzheimer’s disease. To date, Cure Alzheimer’s Fund has contributed more than $132,000,000 to Alzheimer’s research. Many of the projects we have funded resulted in significant breakthroughs, developing a deeper understanding of Alzheimer’s disease, and getting closer to a cure.

Cure Alzheimer's Fund

Our School's global impact would not be possible without the crucial support of our community of committed donors and friends. 

The London School of Hygiene & Tropical Medicine (LSHTM) is renowned for its world-leading research, postgraduate studies and continuing education in public and global health.

With your help, we can increase the number of scholarships we are able to offer. We receive thousands of applications every year, with funding only available to support a small number. 

Our diverse student body is what makes our community so special. Each year, your support funds our LSHTM Fund Scholars, enabling exceptional students to study at our School. We receive thousands of applications every year, with funding only available to support a small number. Without support, many brilliant students like this year's LSHTM Fund Scholar, Judy Baariu (MSc Public Health for Development, 2023) would not have been able to study with us.

LSHTM has over 3,500 staff conducting research in more than 100 countries, with core hubs in London and at the MRC Units in The Gambia and Uganda. Our outstanding, diverse and committed staff make an impact where it is most needed - deploying research in real time in response to crises, developing innovative programmes for major health threats, or training the next generations of public and global health leaders and researchers.

We help shape health policy and translate research findings into tangible impact. We are uniquely placed to lead on transformative approaches to global health and have 120 years of experience tackling big challenges. We are focused on finding new solutions to complex problems and acting upon this knowledge.

We work in collaboration with friends, partners, and supporters to achieve large-scale, long-term impact. Researchers at LSHTM explore all aspects of health challenges, from fundamental laboratory science to policy appraisal and analysis, encompassing statistical, clinical, laboratory, epidemiological and social science research globally.

Our aim is to build strong and dynamic leadership, push the frontiers of knowledge and make an impact where it is most needed. Philanthropy helps us achieve our mission; to improve health and health equity worldwide; working in partnership to achieve excellence in public and global health research, education and translation of knowledge into policy and practice.

London School of Hygiene & Tropical Medicine

Empowering individuals with limited resources to establish and maintain good health.

We are dedicated to providing health services for the uninsured, underinsured or those lacking access to affordable, high-quality preventive health care. We annually serve thousands of people in Mecklenburg County and we are a leader in collaborative efforts to improve community health.

Care Ring

The END Fund is the only private philanthropic initiative solely dedicated to ending the most common neglected tropical diseases.

Our Mission: To control and eliminate the most prevalent neglected tropical diseases (NTDs) among the world's most vulnerable communities and people by 2030. 


NTDs are a group of parasitic and bacterial diseases largely prevalent in tropical regions that currently receive little attention on the global health agenda yet have a significant impact hampering the potential of individuals and communities at large. The devastating effects of NTDs include irreversible blindness, severe disfigurement, stunted cognitive and physical development, especially in children, malnutrition, social isolation, and more. NTDs also cause 170,000 deaths per year. Their comprehensive impact on all aspects of daily life means that the presence of NTDs costs affected countries billions of dollars per year in lost productivity, out-of-pocket expenses, and reduced socioeconomic and educational attainment. 

Currently, 1.7b individuals are affected by such diseases. However, the treatments and knowledge required to eliminate these diseases are readily available, with the annual cost of treatment per individual averaging 50 cents per year. Demonstrating the uniquely cost-effective impact of NTD treatment, studies have shown treatment is the single most efficient means of improving children’s school attendance and capacity to learn. A recent report by Deloitte on Nigeria showcases the significant gains affected economies stand to make should NTDs be eliminated, with Nigeria’s economy estimated to receive an $18.9b boost from now until 2030. The report is available to view here - https://www2.deloitte.com/za/en/nigeria/pages/strategy/articles/Ending_The_Neglect.html

The END Fund helps ensure those at risk of NTDs need not experience such preventable suffering but can live healthy and prosperous lives instead. We do so by working in close partnership with stakeholders across the global NTD community to identify and fulfill gaps and needs in NTD funding, design programs, strengthen the capacity of local actors, provide technical support, and assist with monitoring and evaluation, amongst various additional activities. Our work helps children stay healthy and in school, prevents advanced cases that cause disability and restrain individuals' productive potential, and alleviates the disproportionate disease burden faced by women and girls, as well as the economic burden of disease on families. We have distributed more than 1.2b treatments since our founding in 2012, with 118m individuals treated in 2021 alone.

We envision living in a world in which all have the opportunity to achieve their full potential, with these diseases that have plagued humans for millennia confined to history once and for all.

The END Fund

LEEP advocates to prevent lead poisoning and improve the health, wellbeing, and potential of children worldwide. 

LEEP advocates for regulation on lead paint to reduce lead poisoning and improve the health, wellbeing, and potential of children worldwide. Lead poisoning is a colossal issue causing disability in 815 million children worldwide.

Currently, we are working on programs in Malawi, Zimbabwe, Madagascar and Pakistan, and are looking to expand to another 7 countries in the next year.

To learn more about our work, check out:
https://leadelimination.org/projects/
https://leadelimination.org/faqs/
https://leadelimination.org/blog/

Thank you for helping us to address the problem of lead poisoning, and improve the health of children worldwide.

Lead Exposure Elimination Project (LEEP)

We reduce deaths from breast cancer by providing access to screening, diagnostics and treatment services for all women.

The Rose addresses any barrier that might keep a woman from caring for her own needs. Studies show women often put personal needs on hold while tending to the needs of others. Many women cite costs and lack of access as reasons they delay preventive services. Yet early detection mammography screenings are the most powerful weapons in the fight against breast cancer—which is 98% curable when detected early.

Every service offered by The Rose is available to the uninsured through one of many sponsorship programs. In fact, the whole purpose of the Empower Her® Sponsorship Program is to ensure any woman has access to breast cancer screening, diagnosis and care. From the initial screening mammogram through diagnostic procedures such as ultrasound and biopsies, as well as access to treatment—all are part of the quality breast health care offered at The Rose.

Because every woman deserves The Rose. Every woman deserves quality breast health care.

The Rose

Compass to Care provides Non Emergency Medical Transportation for children fighting cancer and facing poverty to access treatment.

One in five children diagnosed with cancer lives in poverty.

For children whose families are facing poverty paying for the expenses to get to treatment can be a real problem. The best cancer treatment in the world cannot cure a child if he or she has no way to get there. 

Compass to Care, a 501(c)(3) charitable organization, is proud to have a nationwide non emergency medical transportation (NEMT) solution that directly and immediately remove the transportation barriers to help these children get to the hospital for cancer treatment.

If you fund even one tank of gas, you can change the trajectory of a child's life - giving them hope for a healthier tomorrow and a cancer cure.  

Compass to Care

Nearly every minute, a child dies from malaria, a deadly yet preventable disease. Together, we can beat malaria.

Every person around the world deserves to live a healthy, fulfilled life, but malaria threatens this promise for many of the world’s most vulnerable people, including young children, women, and refugees. For more than 15 years, United to Beat Malaria has helped protect more than 39 million people by providing bed nets and other lifesaving malaria prevention and treatment tools. Yet despite tremendous progress made, a child still dies nearly every minute from this deadly disease. Please join us in the global fight against malaria by donating today!

United to Beat Malaria reflects the collective power that we have: As a united front, we can be the generation to end malaria.

United to Beat Malaria

Providing low-income uninsured neighbors with free medical, dental, and mental health care as an expression of Jesus Christ's love

34,000 low-income uninsured neighbors in Idaho's Treasure Valley can't afford healthcare. 

Genesis Community Health is a 501(c)(3) nonprofit clinic providing them with free medical dental and mental health care as an expression of the love of Jesus Christ.

We are a grassroots organization supported by over 200 active volunteers as well as donors, businesses, churches, and foundations throughout the Treasure Valley.

Genesis Community Health

Phare Bio is using AI/deep learning to discover novel classes of antibiotics to address a looming crisis in antibiotic resistance.

Phare Bio is an ambitious social venture using novel AI and deep learning approaches to antimicrobial development in collaboration with Professor Jim Collins at MIT, a founder of the field of synthetic biology. Phare is a recipient of the Audacious Project, a collaborative funding initiative between TED and other non-profits to unlock social impact on a grand scale. 

The rapid evolution of antibiotic-resistant bacteria and a dwindling discovery pipeline have resulted in an antimicrobial resistance (AMR) crisis. Today, according to the Centers for Disease Control and Prevention, someone in the U.S. acquires a resistant infection every 11 seconds; every 15 minutes someone dies as a result of one. Covid-19 has only highlighted the urgency with approximately 15% of hospitalized patients suffering from bacterial co-infections. There is a critical need for new antibiotics, and yet, pharmaceutical and biotechnology companies have largely abandoned the space in favor of more lucrative markets. 

Phare Bio launched in 2020 to tackle this critical unmet need with the latest advances in machine learning to develop entirely novel antibiotics. Integrating world-class expertise and decades of experience in artificial intelligence (AI), bioengineering, and life sciences, Phare is targeting the world's most deadly pathogens, such as Acinetobacter and Pseudomonas, with the goal of developing seven novel classes of antibiotics in seven years. 

Phare Bio

Our mission is to put Judeo-Christian principles into practice through programs that build a healthy spirit, mind and body for all.

YMCA of Greensboro

A movement of people revolutionizing charitable giving to end extreme poverty.

We motivate people to donate 1% or more of their income to the world’s most cost-effective charities, every month, for life. We update this portfolio every year, so your donations are always as impactful as possible.

One For The World Inc

Dedicated to the understanding, treatment and ultimate cure of substance use disorder by funding cutting-edge research. 


Cure Addiction Now (CAN) is dedicated to the understanding, treatment and ultimate cure of drug addiction. Funding basic research and its clinical translation through a collaborative program is the core focus of the foundation. In addition to creating new therapies to help stop the deadly cycle of addiction, we hope to eliminate the negative stigma of this disease and ultimately find a cure for the brain’s addiction to drugs. 

Background:
Nancy Davis founded CAN in 2018 with her son Jason Davis who tragically passed away in 2020. Jason’s dream was to fund ground-breaking research to find therapies to help stop the vicious cycle of substance use disorder (SUD) and help people not only detox but stay in permanent recovery. CAN also has plans to fund educational campaigns to remove the negative stigma of SUD and change the narrative. Our mission is to cure addiction now. 

At the beginning of Covid 19, one person in the US would die every 11 minutes of an opioid overdose. That number has multiplied dramatically to one person every minute and a half and this does not include other drug overdoses. 70 percent of all deaths are now caused by Fentanyl. Yes, addiction is a real disease and needs to be treated. There is no other disease claiming so many lives. We need to take the stigma of shame away that addicts suffer and treat them with dignity, kindness and compassion the same way we treat everybody else suffering from any disease. We need to raise important funds for our brilliant doctors that represent Mount Sinai, Harvard, UCLA, Scripps, University of Washington and Johns Hopkins and start saving lives. Please Visit our website for more information and a detailed list of our esteemed Scientific Advisory Board and Collaborating Scientists. Below are the currently funded grants from this year. Thank you for your consideration and support!

2021 Grant Awardees: Research Progress Report as of 10/1/2021

Research Project #1: Developing a Strategy to Prevent Relapse to Opioid, Nicotine, 
Alcohol and Cocaine Use with a Single Use Medication
Courtney A. Miller, PhD, Scripps Research

Substance use disorder (SUD) is a chronic, relapsing disorder with a severe lack of treatment options. Associations that have formed during periods of drug use serve as powerful relapse factors by triggering motivation to seek the drug. Recently, we identified the molecular ATPase and driver of synaptic actin polymerization, nonmuscle myosin II (NMII), as a biological target for the selective disruption of these associations. A single treatment with the NMII inhibitor Blebbistatin (Blebb) produces an immediate, seemingly permanent loss of motivation for methamphetamine (METH) and amphetamine (e.g. Adderall) by targeting the associated memories. This occurs without the need for retrieval and without affecting other types of memories, including those associated with other drugs of abuse. In addition to its efficacy in animal relapse models following a single treatment, several properties made Blebb an excellent starting point for medication development. Paramount among these are the molecule’s high brain penetration (thus, lower doses can be used) and rapid clearance from the body and brain (limiting unwanted peripheral and central effects on the body). Unfortunately, Blebb’s activity at cardiac muscle myosin II (CMMII), a protein critical for heart function, was a liability. Through work funded by the NIH, including NIDA, we have developed a preclinical candidate compound, MT-110, that retains Blebb’s high brain penetrance and rapid clearance, but no longer inhibits CMMII. The result is a dramatically improved safety profile and a therapeutic index (ratio of the lowest dose that achieves the desired effect and the highest tolerable dose) of at least 25x. We have filed a non-provisional patent in the US and ten other countries, declared a preclinical candidate, and are now preparing to file an IND with FDA and designing our first in human Phase 1 trial. Recognizing that it would be powerful to utilize the Blebb-based NMII inhibitor to target motivation for other widely used drugs of abuse, particularly opioids, alcohol, nicotine and cocaine, we have begun working on a strategy. Blebb disrupts restabilization of these memories when animals are exposed to reminders associated with the drug of abuse. However, for individuals that use drugs, associations capable of motivating drug seeking can number in the hundreds and even be unconscious motivators. Therefore, it is not feasible for subjects to actively retrieve all “triggers” in a clinical setting for reconsolidation targeting. Interestingly, recent evidence in animal and human studies indicates a similar disruption can be achieved by pairing a reconsolidation disrupting intervention with a small amount of the drug of abuse itself. We now have promising preliminary preclinical data using this strategy that points to the potential for MT-110 in cocaine, nicotine and opioid use disorders. Additional studies to validate and extend these findings are underway. 

Research Project #2: 
Role of chemosensory processing in choroid plexus circuit in drug addiction
Paul J. Kenny, Ph.D. and Stephanie P.B. Caligiuri, M.D., Mount Sinai, New York

Sensitivity to the aversive properties of addictive drugs influences vulnerability to substance use disorders (SUDs). Indeed, aversive reactions to drugs of abuse upon their first usage decreases the likelihood that subsequent use will transition from occasional to habitual. Little is known about the mechanisms of drug aversion. Taste systems guide ingestive behaviors to ensure survival by detecting sweet, salty, & umami flavors, which represent carbohydrates, electrolytes, and protein respectively. Taste systems also detect sour and bitter tastes, which often reflects spoiled or poisonous substances. Intriguingly, most addictive drugs are bitter-tasting plant-derived alkaloids, a class of compounds known to activate taste-2 receptors (T2Rs). In addition to their abundant expression in the oral cavity, accumulating evidence suggest that T2Rs are also expressed outside the oral cavity. Individuals carrying genetic variation in genes that encode components of the T2Rs and related signaling machineries are at increased risk of developing SUDs. With the support of Cure Addiction Now (CAN), we are testing the hypothesis that oral and/or extra-oral T2Rs are activated by opioids and other classes of addictive drugs, and that this action contributes to their aversive properties that protect against SUDs. Using genome editing technologies and cellular assays of T2R function, we have collected compelling data suggesting that drugs of abuse stimulate T2R signaling. We have also shown that the same neurons in brain aversion centers that are activated by consumption of noxious bitter compounds such as quinine are also recruited by drugs of abuse. Moreover, we have shown that genetic manipulations that selectively perturb T2R signaling attenuated aversive responses to drugs of abuse and increases their consumption. Perhaps most surprisingly, we found that T2R-mediated aversive sensory information related to drugs of abuse is routed to the choroid plexus in the fourth ventricle, a secretory organ in the brain, and that manipulating genes in the choroid plexus regulates aversive behavioral responses to addictive drugs. These data reveal a novel chemosensory mechanism that regulates addiction-relevant behavioral responses to drugs of abuse that may serve as a substrate for the development of target therapeutics for SUDs. 

Research Project #3
The Kappa Opioid Receptor: A Therapeutic Target for Negative Affect in Pain and Addiction
Catherine Cahill, Ph.D. and Edythe London, Ph.D., UCLA

Anhedonia is the impaired capacity to experience pleasure from naturally rewarding objects and events.  It is defined as a state of ‘markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day’.  While it is relatively undertreated, it occurs in many neuropsychiatric disorders including substance use disorders and chronic pain. Considering the high comorbidity between negative affective states, such as depression and chronic pain, it is not surprising that anhedonia may be a driver of opioid addiction, where opioid misuse is a predictor of anhedonia. 

Kappa opioid receptor agonists produce dysphoria, depressive-like symptoms and psychotomimetic effects in humans, and they elicit aversion and depressive-like behaviors in preclinical models. A novel kappa receptor antagonist JNJ-67953964 produced anti-anhedonic effects in a recent, multicenter, double-blind, placebo-controlled, randomized clinical trial.  Given the involvement of this receptor in negative affective states and the positive preliminary clinical study in alleviating anhedonia, our studies focus on kappa receptors with the goal of facilitating the development of medications for Opioid Use Disorder.

Our first aim was to determine the association of kappa binding in limbic regions of brain with measures of negative affect in a model of chronic pain. To date, we have demonstrated kappa receptor binding in the striatum using microPET and 18F]LY2459989, a novel kappa radiotracer. Binding of this tracer was blocked by both a kappa-receptor selective antagonist the nonselective opioid antagonist naloxone.  We have also conducted longitudinal studies were animals were imaged over time to correlate changes in receptor binding with the development of negative affective states.  Analysis of these data are ongoing.

Studies in people who misuse heroin show that acute opioid withdrawal increases opioid craving and seeking behavior, and that the severity of withdrawal predicts the response to treatment.  We therefore have conducted microPET imaging in opioid-dependent rats during the acute phase of opioid withdrawal. Analysis of these studies are ongoing.



Cure Addiction Now

We help people in crisis by providing emergency health services, and then promote self-reliance through training.

We are a global humanitarian organization dedicated to saving lives and relieving suffering. Established in 1984 by volunteer doctors and nurses, we are a nonprofit with no political or religious affiliation, and now have more than 7,500 staff members around the world, more than 97% of whom are local. Our mission is to improve the quality of life through health interventions and related activities that strengthen underserved communities worldwide. With the flexibility to respond rapidly to emergencies, we offer medical services and training to people at the highest risk, always working to strengthen local healthcare systems and promote self-reliance.

International Medical Corps

Seeking economic justice for the family-scale farming community. Through research, advocacy, and economic development our goal is to empower farmers - partnered with consumers - in support of ecologically produced local, organic and authentic food.

The Cornucopia Institute

Whistler Adaptive Sports offers a full range of adaptive sports programs and a dynamic learning centre in Whistler, BC. Canada. 

For over 20 years, the Whistler Adaptive Sports Program Society has been removing barriers to adventure for people with disabilities and neurodiversity, offering a full range of adaptive sports programs and a dynamic learning centre in Whistler, BC. Canada. We currently operate in Squamish, Whistler, Pemberton and Mount Currie. We also serve locals from across B.C. and visitors from Canada and around the world. 
 
Whistler Adaptive is committed to introducing individuals with a disability to sport, recreation and therapeutic sport programming. Whistler Adaptive supports sport for life by breaking down the financial, physical and social barriers as well as creating skills that will lead to future employment within sport and beyond. Whistler Adaptive empowers individuals through access to one of the world's best mountain resorts, providing them with the environment, support and opportunity to become physically active and focus on their abilities rather than disabilities. Programs are accessible to both children and adults with cognitive and physical disabilities. 

Whistler Adaptive serves locals in its community and visitors from across Canada and around the globe. All activities are run in a safe and supportive environment, allowing athletes to learn at their own pace. We pride ourselves on being able to change lives through the innovative sports programs we offer and the help we provide. Whistler Adaptive paves the way by increasing knowledge of adaptive sports through training and coaching clinics and values the consistent support that we receive from our volunteers. We seek to remove barriers to adventure and learning by training athletes with a real sense of passion. OVER 20 YEARS, 18 SPORTS PROGRAMS AND GROWING… The Whistler Adaptive Sports Program Society has been in operation for over 20 years with a record 3,000+ lessons taught in 18 adaptive sports. Through generous donations, we allocate resources for equipment and volunteer training to work with a range of individuals and athletes. Alpine skiing and racing, snowboarding, Nordic skiing, hiking and trail riders, hand-cycling, biking, canoeing, kayaking, rowing, swimming, triathlons, running, yoga and gymnastics are all part of Whistler Adaptive programming and our philosophies on "Grassroots to the Podium" and "Sport for Life". How we do it...The people here at Whistler Adaptive feel that sport builds socialization, leadership skills, healthy growth and development for everyone, whether they have just acquired a disability or have been active all their lives. By providing access to a vast number of sports across the winter and summer seasons, we are opening doors to endless opportunities and creating new levels of independence for individuals with disabilities. 

Whistler Adaptive Sports Program Society

Help us prevent, diagnose and cure heart rhythm diseases

Preventing, diagnosing, and curing heart rhythm diseases Bringing together national and international expertise from many disciplines within a single institute, Liryc is committed to  advancing medicine and providing better care for patients with heart rhythm disorders. Bringing innovative and personalized therapies to life Liryc teams aim to develop innovative technologies for diagnosing and treating heart rhythm disorders. Liryc, through its unique multidisciplinary and international infrastructure, promotes collaboration between research teams, clinical teams and economic players, which enables the emergence of innovative projects to invent diagnostic tools, cutting-edge medical devices, and therapies of the future. Why support Liryc? 30% of cardiovascular diseases are caused by a heart rhythm disorder. There are three heart rhythm disorders related to failures in the electrical activity of the heart: atrial fibrillation, ventricular fibrillation and heart failure. These diseases affect millions of people worldwide, either chronically or acutely, or even immediately and fatally. Regardless of your age, you can be affected. As can your loved ones. Heart rhythm disorders cause each year: 
 20 % of strokes in the world 
 325,000 sudden cardiac deaths in the United States, 90% of which are fatal 
 1M hospitalizations for heart failure in the United States 
 Donate to advance cardiology research Regarding all these broken lives and the suffering of patients and their loved ones, it is urgent to find solutions. Your support helps us fight these disorders through the prevention and treatment of cardiac arrhythmias and training for healthcare professionals by: 
 Funding new research projects to further understand cardiac electrical disorders, 
 Purchasing new equipment to provide experts with the best technology and tools available to advance medical innovation, 
 Supporting education and training programs to disseminate knowledge in more healthcare centers worldwide and to ensure all patients benefit from therapeutic advances. 
 " It is a real public health issue. Sudden death cause as many deaths in France as breast, lung and colon cancer combined, or 50,000 deaths per year, or 1 death every 10 minutes ," according to Professor Michel Haïssaguerre, Founder and Honorary President of Liryc. 

Liryc Heart Rhythm Disease Institute

Re-imagining healthcare for vulnerable and underprivileged people in Athens, Greece.

IRIS Humanitarian Response is a health focused non-profit organisation based in Athens, Greece.

We are dedicated to advancing access to healthcare and delivering high quality medical care for individuals and communities in need. Our goal is to bridge the gap in health disparities and improve health outcomes for disadvantaged and underserved people. Through our work, we strive to make a lasting impact by promoting health equity and the human right to health.

Our mission is to serve vulnerable, marginalised, underprivileged individuals and communities by improving their health and wellbeing - with the ultimate goal to alleviate suffering and restore their dignity and hope.

We are committed to achieving this through:

• upholding the right to health
• providing medical services in the areas of promotion, prevention, treatment and rehabilitation
• ensuring access to medicines and health products
• implementing public health interventions
• removing obstacles and creating innovative ways to access and navigate essential healthcare services

IRIS Humanitarian Response

We give small mills everything they need to add vital nutrients into the food that millions of malnourished people eat the most.

Sanku combats hidden hunger and saves lives by giving small mills the tools needed to fortify maize flour, an East African staple. Our mission: Guarantee that every meal consumed by every mother & child contains vital nutrients, forever. 

Worldwide, 8,000 children die every day and 2 billion suffer from preventable illness because their diets lack basic vitamins and minerals. Fortification (adding life-saving micronutrients to processed foods) is the most cost-effective nutrition intervention, but it has failed to reach the 6.5 billion people in developing countries who rely on small, often rural, mills for most of their food.

Sanku developed a technology and business model to enable the small mills that feed the most malnourished people to conveniently and affordably fortify staple grains. Our technology adds precise levels of nutrients into flour during processing and our business model leverages economies of scale to offset any additional costs for millers and their customers, providing Sanku with revenue margins that increase as we scale. We are currently reaching 3 million East Africans with the basic human right of nutritious food and have a plan to reach 100 million this decade, which will prevent millions from death and disease, boost productivity, and save billions of dollars in GDP.  

A donation of ~$1 is enough to give one person access to nutritious food for an entire year, so even a small donation can go a long way in the fight against malnutrition.

Sanku

Connecting scientists and public officials to improve the management of Global Catastrophic Risks in Latin America and Spain.

Riesgos Catastróficos Globales is a science policy organization on a mission to improve the management of Global Catastrophic Risk in Latin America and Spain.

Our team works together with experts and public officials to co-create policies that identify, prevent and mitigate the effects of global risk.

Our current focus areas include 1) food security during abrupt sun-reducing scenarios, 2) monitoring and responding to disease outbreaks in Latin America, and 3) Artificial Intelligence regulation in Spain.

Your support will enable our research and advocacy efforts.

Riesgos Catastroficos Globales(RCG) is a project of Players Philanthropy Fund a Maryland charitable trust recognized by IRS as a tax-exempt public charity under Section 501(c)(3) of the Internal Revenue Code (Federal Tax ID: 27-6601178).  Contributions to Riesgos Catastroficos Globales(RCG)  qualify as tax-deductible to the fullest extent of the law.

Riesgos Catastróficos Globales (RCG)

At Noora Health, we believe no human being should suffer because of a preventable medical condition.

Noora Health is focused on improving patient outcomes in public health systems in India, Bangladesh, and Indonesia by training the family caregivers of patients admitted to government hospitals - making them an integral part of healthcare delivery. They develop high quality training and education materials (videos, flipcharts etc) delivered through a train the trainer model for healthcare professionals to use in-hospital to upskill and train the family and patient. They also have a post-discharge follow-up on mobile (via WhatsApp, teletraining, and voice messages) that allows them to share content with families when they return home, be there in a moment of need, answer questions etc. 

They have seen remarkable outcomes – in a cohort of patients, the program reduced post-surgical cardiac complications by 71%, maternal complications by 12%, newborn complications by 16%, newborn readmissions by 56%, and newborn mortality by 18%. 

Noora Health is in the scale-up phase of their work, aiming to reach 70 million caregivers in the next five years (they recently surpassed 3 million), and they are eager to leverage their digital capabilities to achieve this with high fidelity to the quality they are known for. 

Noora Health

Lebanon Community Hospital Foundation exists to support the improvement and expansion of Samaritan Lebanon Community Hospital.

Founded in 1998, the Lebanon Community Hospital Foundation solicits and administer funds and provides financial support for improvement and for expansion of Samaritan Lebanon Community Hospital facilities and services. Samaritan Lebanon Community Hospital is a 25- bed critical access hospital serving the east Linn County region including Lebanon, Sweet Home, Brownsville and surrounding communities. Since establishment, over $18 million has been raised and distributed to upgrade the hospital and associated clinics, expand services, and enhance the patient experience. Projects funded by the foundation include the addition of healing gardens designed by internationally renowned landscape architect Hoichi Kurisu, a significant remodel of the emergency room and operating rooms at the hospital, and the building of a new 15,000 sq. ft. facility to support patients undergoing treatment for substance use disorders.

The current foundation priority is raising funds to support the construction of a new 17,000 sq. ft. family medicine clinic and urgent care in the community of Sweet Home. This project will open in fall 2023 and will include a helipad and pharmacy. This project will significantly increase access to health care. 

Lebanon Community Hospital Foundation 

Our purpose is to lead the fight against cancer. 

The Cancer Association of South Africa (CANSA) is a leader in the fight against cancer since 1931. Our purpose is to lead the fight against cancer. Our mission is to be the preferred non-profit leader that enables research in lowering cancer risk, educating the public regarding symptoms, screening and risk reduction, and providing care and support to all those affected by cancer.
CANSA is committed to connecting people facing cancer with information, day-to-day help and much-needed emotional support. We aim to ensure that cancer survivors and their loved ones do not face cancer alone.
While we are not privy to medical diagnoses and the onus falls on the patient or their family (with their permission) to contact CANSA for assistance, we are here to support them through every step of their cancer journey.
Through the selfless support of our sponsors like yours, we can continue the fight against cancer in South Africa and advance closer to the goal of a cancer-free society in our generation.

OUR SERVICES
CANSA offers a wide range of services to those affected by cancer:
• Health Awareness Programmes - comprises health education campaigns centred on creating awareness of cancer symptoms, the importance of screening and lowering cancer risk
• Mobile Health Clinics – bring awareness to men and women in rural areas who would otherwise not have access and operates on sponsored funds.
• Promote early detection - CANSA Care Centres countrywide offer screenings and early detection programmes.
CANSA ORGANISATIONAL PROFILE
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• CANSA Care Centres - offer care and support services to those affected by cancer, including employee wellness programmes, stoma support, wigs, prostheses, assistive devices and medical equipment hire, clinical support, counselling (face-to-face and Tele Counselling), support groups and home-based care.
• CANSA Care Homes – provide patient care and support to the main metropolitan areas for out-of-town cancer patients undergoing treatment.
• CANSA TLC Lodging – provides lodging and support services for parents and guardians of children undergoing cancer treatment.
• CANSA Help Desk - Toll free 0800 22 66 22
• WhatsApp helplines – offer multilingual support services in English, Afrikaans, isiXhosa, isiZulu, Sesotho and Siswati.
• Online support groups and platforms – help patients and loved one’s cope with a cancer diagnosis or connect with others walking a similar path as they fight cancer.
• Social media platforms and CANSA Website – make information available to the public.
• CANSA Tele-Counselling – offers a confidential, professional, cancer-related telephonic counselling service to cancer patients, caregivers and their families, and parents or guardians of children living with cancer. This service is free of charge and available in seven languages - English, Afrikaans, isiXhosa, isiZulu, siSwati, Sesotho and Setswana.
CANSA VOLUNTEERS
CANSA is a volunteer-driven organisation, relying on our trained volunteers to assist in delivering our services to local communities across South Africa. We have various volunteer opportunities and trainings available.
CANSA IS COMMITTED TO SUPPORTING THE GLOBAL UNITED NATIONS SUSTAINABLE DEVELOPMENT GOALS (SDGs)
The Sustainable Development Goals or Global Goals are a collection of 17 interlinked goals designed to be a ‘blueprint for achieving a better and more sustainable future for all". The SDGs were introduced in 2015 by the United Nations General Assembly and are intended to be achieved by 2030. CANSA strives toward achieving these goals within our capabilities.
We have identified the Global Goals (SDGs) CANSA has contributed to, in some capacity, during the reporting period with an emphasis on Goals 3 (Good health and wellbeing), 4 (Quality Education) 5 (Gender Equality), 7(Affordable and clean energy) 8Decemt Work and economic growth),9 (Industry innovation and infrastructure) 10 (Reduced inequalities), 11 (Sustainable cities and communities), 12(Responsible consumption and production), 13 (Climate action), 14 (Life below water), 15 (Life on land), 16 (Peace, justice and strong institutions, and 17(Partnership for the goals).

CANCER SCREENINGS (Stats 2020/21)
• Over 54 210 conducted in total (with abnormalities referred accordingly)
• Conducted over 6 260 pap smears and facilitated 2 989 in partnership with the Department of Health (DoH)
• Carried out more than 20 570 clinical breast examinations.
• 8 848 Prostate Specific Antigen (PSA) tests completed and 351 done in partnership with DoH.
• Over 3 010 skin examinations using the FotoFinder Mole Analysis device took place.
• Expanded workplace screening and wellness programmes.
HEALTH SCREENING, EDUCATION AND AWARENESS (Stats 2020/21)
• Approximately 40 727 individual information and education sessions conducted with screenings.
• Over 7 560 people assessed to determine their lifestyle risk, with 2 361 glucose tests performed for diabetes.
• More than 465 900 people reached through 1 738 talks and 4 531 exhibitions with the help of 795 health promotion volunteers.
• Over 150 radio talks hosted for cancer education.
• Distributed over 71 110 information leaflets to promote health awareness campaigns.
CANSA ORGANISATIONAL PROFILE
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• More than 79 700 youth reached through 402 school programmes.
• Our CANSA Helpdesk responded to over 12 680 enquiries for support and information via telephone, WhatsApp, email, website and social media.
CURRENT PLANS AND THE FUTURE
CANSA’s service and income generation is managed and deployed centrally with national teams, placed across the country. We streamline and modernise our service and fundraising efforts regularly. We have CANSA Care Centres around the country with certain CANSA Care Centres operating as ‘Virtual CANSA Care Centres’ where employees work remotely to offer services within their surrounding communities assisted by willing volunteers.
2022, is showing us that our country’s economic recovery post COVID-19 will take a few years. The need for our normal services continues and even more patients and caregivers need help. We are aware of our duty to continue to educate South Africa about the cancer burden and find innovative ways to help lower the cancer risk, while providing support and care to the communities we serve.

Cancer Association of South Africa (CANSA)

Supports highly-impactful, evidence-based solutions to the challenges of global poverty and inequality.

The Global Health & Development Fund addresses the vast inequalities in health, wealth, and opportunity.

While many people alive today can expect to have greater wealth than generations before us, millions of people live in poverty, and billions more struggle to get by. They may lack access to basic healthcare and vaccinations, making them far more vulnerable to deadly diseases, or to quality education, which strengthens their economic future. These are complex, but not unsolvable, problems. Researchers, advocates, and organizations around the world are working to scale up solutions to these problems. By taking a thoughtful, evidence-based approach to philanthropy that accelerates the best of these solutions, we can do immense good.

The Founders Pledge Global Health and Development Fund identifies and supports highly-impactful and neglected development initiatives. By pooling donations and collaborating with other funding and research organizations, this Fund allows individuals to make contributions when and where they will have the largest impact. We aim to:

- Significantly improve the lives of the world's most vulnerable people;
- Eliminate deaths from easily preventable disease;
- Support sustainable, systemic change.

### Our Approach to Grantmaking

When evaluating potential grants, we consider several key points:

- **Counterfactual impact**. Our grants are designed to create a meaningful outcome that would not otherwise have happened. This means that you can rely on the Funds to create meaningful, real change, rather than just maintaining the status quo.
- **Impact-driven philanthropy**. This fund prioritizes the highest-impact solutions to challenges. We assess where the gaps are, which opportunities may be neglected by other funders, and where the biggest wins are in terms of making the biggest difference.
-  **The organization’s funding gap**. Not all organizations are set up to scale up their programming and some may not be able to productively absorb large amounts of unsolicited funding at any given point. We evaluate all potential grantees’ capacity for growth and consider how much money they could put to good use.
-  **Organizational strength**. Particularly with unrestricted funding, it’s important to have trust in the leadership and capacity of the organizations we support. We look at their track record of success and their transparency about failures as well as successes, and we only support those organizations which are exceptionally well run.
- **Time-critical opportunities and funding certainty**. While Founders Pledge members give to our top climate charities regularly, sometimes there are time-critical opportunities which require fast decisions. We will use the Fund to make grants that enable such short-term opportunities and stability for high-impact funding opportunities thereby increasing the impact compared to individual giving to specific organizations.

### Frequently-Asked Questions

**Can charities apply for money from the Fund?**

The Funds do not generally accept applications from charities, and we request that charities do not send unsolicited applications for funding. If the Fund Managers choose to open up an application round, this will be publicized. 

**How frequently will you make grants from the Fund?**

In general, Fund Managers will review grantmaking decisions on a quarterly basis. Decisions will be made based on the value of Funds and the available options for high-impact grantmaking. We may disburse funds outside of quarterly review dates if we become aware of a particularly promising and time-sensitive funding.

**How will my contribution be used?**

All funds are granted out. The Fund is not an investment vehicle. The Fund does not use any percentage of contributions to cover staff time or other overhead costs. Every dollar contributed to the Fund will be used to make grants directly to end-user organizations creating a real difference.

### More Questions?

To learn more about the Founders Pledge Global Health and Development Fund, please visit [founderspledge.com](https://founderspledge.com/funds/global-health-and-development-fund) or email the Fund Managers at [funds@founderspledge.com](mailto:funds@founderspledge.com).

Founders Pledge: Global Health & Development Fund

Dedicated to the sustainable elimination of iodine deficiency worldwide.

According to the World Health Organization, iodine deficiency is the world’s most prevalent, yet easily preventable, cause of brain damage in children. Nearly 50 million people have stunted cognitive and motor development as a result. Severe stunting can be as bad as a loss of 15 IQ points, meaning children who don't get enough iodine struggle at school and in later life. The solution is simple, and has already been implemented in many countries: national level fortification of salt with iodine. IGN works with governments to implement such programmes. Despite not being directly related to schools, removing this barrier to healthy development is one of the cheapest and easiest ways to include children's educational outcomes.

Iodine Global Network

Health & Help assists people in places where it is difficult or impossible to access basic medical care. 

What do we do?

• Provide access to basic medical services and prescriptions.
• Hold educational lectures about health and ways to prevent illness in the
future.
• Prepare volunteers for their time on site at the clinics, as well as help all
employees learn and grow.
• Provide medical students with the opportunity to get hands-on experience
under the guidance of skilled doctors.
• Develop and implement medical programs on a continuous basis.

For whom?
• For unprotected and discriminated groups within the population.
• For those who cannot pay for treatment or buy medications because it is
too expensive or simply not available.
• For socially responsible, generous patrons, both private and corporate.
• For everyone who wants to become better versions of themselves by
helping others.

Where?
• In regions with limited resources and developing infrastructure
• In locations where medical care does not exist or is extremely
underdeveloped (lacking sufficient personnel, equipment, medicine).

How?
• About 70 volunteers from all over the world work for the project online. The
clinics have up to 20 medical specialists and volunteers in other professions from different countries working 24/7.
• Many generous people and companies from different countries around the world support the project through financial donations, and by providing medications, equipment, and other supplies.

Health & Help

Global nonprofit that harnesses the power of data science and AI in the service of humanity.

DataKind leverages data science and artificial intelligence (AI) to aid social impact organizations, enhancing their effectiveness and understanding to tackle global issues. With our expertise and volunteer network, we accelerate progress in economic opportunity, humanitarian aid, frontline health, and climate resilience. DataKind transforms the promise of "data for good" into tangible solutions.

DataKind

We provide comprehensive oral health care for people in need of all ages. Serving 50,000 patients annually at 5 clinics in MN. 

Our mission is to provide culturally sensitive community oral health care, preventive education, professional training, and to advocate for access for all. 

Our vision is that all people will have access to high quality, affordable dental care to improve their overall health in a convenient, caring, and respectful environment.

We are a nonprofit organization, and we serve patients from all walks of life and economic circumstances. We want to make high-quality dentistry available to anyone who needs care. We have over 200 dedicated employees, including dentists, hygienists, assistants, and an administrative team who are continually improving care and delivering the best possible dentistry.

Community Dental Care

We enable working professionals to maximize their positive impact by supporting them in donating their various resources.

We empower working professionals to have the biggest positive impact possible. We are building a community of professionals working together for the greater good, contributing not only through their money but also with their time and skills according to the principles of effective altruism.

High Impact Professionals is a project of Charity Entrepreneurship operating through a fiscal sponsorship with Players Philanthropy Fund (Federal Tax ID: 27-6601178), a Maryland charitable trust with federal tax-exempt status as a public charity under Section 501(c)(3) of the Internal Revenue Code. Contributions to High Impact Professionals are tax-deductible to the fullest extent of the law.

High Impact Professionals

Providing affordable, quality, medical, dental, mental health & pharmacy services through our 5 Los Angeles locations since 1967. 

We’ve come a long way since we opened our doors as the Los Angeles Free Clinic in the Summer of Love, 1967. From a single storefront on Fairfax Avenue, we are now the Saban Community Clinic, with four health centers and one satellite site providing comprehensive medical, behavioral health and dental care plus access to social services.

While a lot has changed over the past 50 years, our founding belief remains the same: that healthcare is a right, not a privilege. The integrated and holistic approach to treating the entire individual, which we pioneered five decades ago, is practiced today as Whole Person Care.

Saban Community Clinic

ANR/F saves lives from secondhand smoke with grassroots organizing, advocacy, and education.

ANRF is a 501(c)(3) educational nonprofit organization advancing health equity with comprehensive programs to prevent the harmful effects of secondhand smoke and smoking among youth and adults. 40 years of experience promoting prevention and education about smoking, secondhand smoke, and exposing tobacco industry interference with public health policies. Our goals include educating the public about the health effects of secondhand smoke and the benefits of smokefree environments. Ultimately, our efforts are intended to create a smokefree generation in America that rejects tobacco use and is savvy to tobacco industry tactics. Our sister organization Americans for Nonsmokers' Rights (ANR) is a 501(c)(4) and is the leading lobbying organization dedicated to nonsmokers' rights, working to close the gaps in smokefree protections in thousands of communities nationwide.

American Nonsmokers' Rights Foundation

Common Threads aspires to build communities that embrace healthy cooking, healthy eating and celebration of culture.

Common Threads is a national nonprofit that provides children and families cooking and nutrition education to encourage healthy habits that contribute to wellness. We equip under-resourced communities with information to make affordable, nutritious and appealing food choices wherever they live, work, learn, and play. We know that food is rooted in culture and tradition so we promote diversity in our lessons and recipes, encouraging our participants to celebrate the world around them.

Common Threads

Palm Health Foundation Palm Beach County's community foundation for health. Over $90 million invested in community.

Palm Health Foundation is Palm Beach County’s community foundation for health. With the support of donors and a focus on results, the foundation builds strong community partnerships, respects diverse opinions, advocates for its most vulnerable neighbors and inspires innovative solutions to lead change for better health now and for generations to come. The foundation supports health equity for Palm Beach County residents of all backgrounds, heritage, education, incomes and states of well-being. Palm Health Foundation has invested more than $90 million in Palm Beach County health since 2001. 

Palm Health Foundation 

Founders Pledge is a global nonprofit empowering entrepreneurs to do the most good possible with their charitable giving. 

We equip members with everything needed to maximize their impact, from evidence-led research and advice on the world’s most pressing problems, to comprehensive infrastructure for global grant-making, alongside opportunities to learn and connect. We’re grateful to be funded by our members and other generous donors. 