Wings for Life has one goal: to find a cure for spinal cord injury. We fund cutting-edge research and clinical trials worldwide.

**$1 DONATION = $1 FOR SPINAL CORD RESEARCH**

- Our mission is clear: to find a cure for spinal cord injuries. We fund cutting-edge scientific research and human clinical trials in the USA and around the globe to heal the injured spinal cord.
- 100% of all donations are used for research purposes because the Red Bull company bears all of the administrative costs of our foundation.
- Progress in spinal cord injury research is largely driven by private funding, so donations from individuals and companies are essential.

Wings for Life USA - Spinal Cord Research Foundation Inc.

High quality medical services for marginalized groups in Cairo and the region.

Mersal Foundation for Charity and Development is a non-profit organization that serves in the health field and works on providing all types of healthcare with high quality to whoever is in need.

**Vision**
To be the number one medical organization in Egypt and the Arab region and proactive in ensuring the right in healthcare for the marginalized groups and those who are in need the most.

**Message**
Working on analyzing and filling the gaps of the healthcare system to provide high quality medical services on the basis of equality and dignity through enabling a charitable healthcare system for whoever cannot afford it, as well as contributing to the development of the health sector.

**Objectives**  

- Providing medical services to whoever deserves them regardless the cost or for how long they will be needed.
- Spreading medical awareness in all the places it serves in.
- Achieving sustainability in funding its activities Core Values.
- Privacy: Mersal ensures the patient's eligibility to receive its services without hurting their dignity or exposing them to any kind of embarrassment.
- Healthcare With No Discrimination: Mersal is an open arm to all patients with no discrimination whatsover; whatever religion, nationality, color, or language, all patients in need are welcomed to receive the organization services.
- High Quality: Mersal provides all types of medical services in the highest possible quality through its network of specialized medical personnel.
- Credibility and Transparency: Mersal announces the size and sources of its fund as well as its administrative and medical expenditures, The foundation financial reports and annual budgets are available through several outlets through which any person can explore how resources are managed. Mersal believes in the importance of being specialized in specific fields and its early choice was the healthcare services.

In the past six years, the organization registered over 25,000 patients from 27 provinces.  Mersal has been seeking to enable access to its services all over the country. And the dream of helping those who are in need whoever they are and whatever the cost and time is still alive, Mersal has worked over the past six years on getting close to its patients throughout their treatment journey.

Mersal Foundation for Charity and Development 

Zig is a general-purpose programming language and toolchain for maintaining robust, optimal, and reusable software.

The Zig Software Foundation is a non-profit corporation founded in 2020 by Andrew Kelley, the creator of Zig, with the goal of supporting the development of the language. Currently, the ZSF is able to offer paid work at competitive rates to a small number of core contributors. We hope to be able to extend this offer to more core contributors in the future.

Zig Software Foundation Inc

Delivering unconditional cash directly to the world's poorest households via secure mobile transfers. 

Since 2009, GiveDirectly has delivered more than $580 million in unconditional cash transfers to families in need. These one-time cash transfers allow recipients to invest in what they need most and have been shown to improve their earnings, children’s school attendance, health, nutrition, and mental well-being.
 
GiveDirectly uses government data to target villages where most or all residents are living in extreme poverty, defined by the World Bank as earning under $2.15/day. In-country GiveDirectly staff enroll one member of each household in the entire village to receive a one-time transfer of about $1,000 USD sent in two installments using mobile money. Recipients can then withdraw the mobile funds as cash with local agents and use the funds to invest in what they need – whether it’s on starting a business, education, making their home safer/sturdier, healthcare, or livestock.
 
GiveDirectly uses rigorous experimental research (randomized controlled trials) to measure the impact of their unconditional cash programs and answer public policy questions, generating evidence on key design and implementation questions across varied contexts. You can find over 300 studies on the positive impacts of cash transfers in GiveDirectly’s Cash Research Explorer.

GiveDirectly

Odylia Therapeutics is a nonprofit biotech working to accelerate the development of treatments for people with rare diseases.

At Odylia, we accelerate therapeutic development for people with rare diseases, changing the way treatments are brought from the lab to the clinic. We strive to bring life altering treatments to people with genetic disease regardless of prevalence or commercial interest. 
Odylia is shifting the paradigm to focus on proven science and removing traditional roadblocks. We work to lower costs, reduce development time, focus research, and continuously drive successful programs towards clinical trials and regulatory approval. Strategic collaborations with patient groups, research labs, and commercial partners facilitate our work to ensure treatments are safe, effective, and ultimately reach patients who need them.

Odylia challenges the traditional approach to drug development through:

1. Lower cost of development
Lower licensing fees to decrease development costs and ensure continued commitment to program success

2. Increase speed of development
Challenge traditional approaches through regulatory engagement

Streamline development through strategic partnerships and a platform approach to drug development

3. Enable the entire ecosystem
Provide expertise through in-house Brydge Solutions and leveraging the Odylia Board

Enable the entire ecosystem through Initiatives that impact the broader field

Odylia Therapeutics

Extending and improving the lives of people with ALK+ lung cancer by raising funds for research and patient support programs.

**Our Vision**

We envision a world where ALK+ lung cancer is a chronic or even curable condition and the next person diagnosed with lung cancer does not have to live under the current stigma.

**Our Start**

\#SweatForBreath started as a grassroots fundraising campaign during Lung Cancer Awareness Month in 2023. After being diagnosed with Stage IV ALK+ lung cancer in November 2022, David Cornbrooks became keenly aware that he was benefiting from the selfless fundraising and awareness efforts of the patients before him.

[Listen to David's story here.](https://www.youtube.com/watch?v=lWcS-yN7Qxw)

The \#SweatForBreath campaign in 2023 became David, and his wife, Lisa’s, way to help the next generation ALK+ lung cancer patients.

\#SweatForBreath accelerated beyond more than just a typical fundraiser.  The initiative quickly evolved into a community of patients, caregivers, family, and friends seeking to make David and Lisa's vision a reality and the road to that vision more tolerable. People donated, sweat at the in-person cycle event, posted on social media, and helped fundraise through organizing group walks, selling art, "gifting" donations on behalf of clients, and much more.

Their success in 2023 compelled David and Lisa to officially transition the \#SweatForBreath campaign into the Sweat For Breath Foundation, operating through a fiscal sponsorship with Players Philanthropy Fund, a Maryland charitable trust recognized by IRS as a tax-exempt public charity under Section 501(c)(3) of the Internal Revenue Code (Federal Tax ID: 27-6601178).

**Our Impact**

Since 2023, over **1,450 donors** have given nearly **$400,000** to the Foundation (or its predecessor campaign). 100% of the proceeds have gone directly to The Johns Hopkins Sidney Kimmel Center in Baltimore, MD to support Dr. Vincent Lam’s ALK+ lung cancer research.

This support provided the critical funding needed to launch Dr. Lam’s clinic trial, which will evaluate the safety of a cancer peptide vaccine to prevent or delay acquired resistance in advanced ALK+ lung cancer patients currently on ALK targeted therapy. Dr. Lam’s vaccine is the **first ALK+ vaccine in the world** to be tested in a clinical trial. Dr. Lam administered the vaccine to the first patient **in clinic on May 13, 2024**!

-----------

*The Sweat for Breath Foundation is a project of Players Philanthropy Fund, Inc. a Texas nonprofit corporation recognized by IRS as a tax-exempt public charity under Section 501(c)(3) of the Internal Revenue Code (Federal Tax ID: 27-6601178,[ppf.org/pp](https://ppf.org/pp)). Contributions to The Sweat for Breath Foundation qualify as tax-deductible to the fullest extent of the law.*


The Sweat For Breath Foundation

We want to help lead the fight against cancer.

The Cancer Association of South Africa (CANSA) is a leader in the fight against cancer since 1931. Our purpose is to lead the fight against cancer. Our mission is to be the preferred non-profit leader that enables research in lowering cancer risk, educating the public regarding symptoms, screening and risk reduction, and providing care and support to all those affected by cancer.


CANSA is committed to connecting people facing cancer with information, day-to-day help and much-needed emotional support. We aim to ensure that cancer survivors and their loved ones do not face cancer alone.


While we are not privy to medical diagnoses and the onus falls on the patient or their family (with their permission) to contact CANSA for assistance, we are here to support them through every step of their cancer journey.


Through the selfless support of our sponsors like yours, we can continue the fight against cancer in South Africa and advance closer to the goal of a cancer-free society in our generation.

OUR SERVICES
CANSA offers a wide range of services to those affected by cancer:
• Health Awareness Programmes - comprises health education campaigns centred on creating awareness of cancer symptoms, the importance of screening and lowering cancer risk.
• Mobile Health Clinics – bring awareness to men and women in rural areas who would otherwise not have access and operates on sponsored funds.
• Promote early detection - CANSA Care Centres countrywide offer screenings and early detection programmes.


CANSA ORGANISATIONAL PROFILE
• CANSA Care Centres - offer care and support services to those affected by cancer, including employee wellness programmes, stoma support, wigs, prostheses, assistive devices and medical equipment hire, clinical support, counselling (face-to-face and Tele Counselling), support groups and home-based care.
• CANSA Care Homes – provide patient care and support to the main metropolitan areas for out-of-town cancer patients undergoing treatment.
• CANSA TLC Lodging – provides lodging and support services for parents and guardians of children undergoing cancer treatment.
• CANSA Help Desk - Toll free 0800 22 66 22.
• WhatsApp helplines – offer multilingual support services in English, Afrikaans, isiXhosa, isiZulu, Sesotho and Siswati.
• Online support groups and platforms – help patients and loved one’s cope with a cancer diagnosis or connect with others walking a similar path as they fight cancer.
• Social media platforms and CANSA Website – make information available to the public.
• CANSA Tele-Counselling – offers a confidential, professional, cancer-related telephonic counselling service to cancer patients, caregivers and their families, and parents or guardians of children living with cancer. This service is free of charge and available in seven languages - English, Afrikaans, isiXhosa, isiZulu, siSwati, Sesotho and Setswana.


CANSA VOLUNTEERS
CANSA is a volunteer-driven organisation, relying on our trained volunteers to assist in delivering our services to local communities across South Africa. We have various volunteer opportunities and trainings available.


CANSA IS COMMITTED TO SUPPORTING THE GLOBAL UNITED NATIONS SUSTAINABLE DEVELOPMENT GOALS (SDGs)
The Sustainable Development Goals or Global Goals are a collection of 17 interlinked goals designed to be a ‘blueprint for achieving a better and more sustainable future for all". The SDGs were introduced in 2015 by the United Nations General Assembly and are intended to be achieved by 2030. CANSA strives toward achieving these goals within our capabilities.


We have identified the Global Goals (SDGs) CANSA has contributed to, in some capacity, during the reporting period with an emphasis on Goals 3 (Good health and wellbeing), 4 (Quality Education), 5 (Gender Equality), 7 (Affordable and clean energy),  8 (Decent Work and economic growth), 9 (Industry innovation and infrastructure), 10 (Reduced inequalities), 11 (Sustainable cities and communities), 12 (Responsible consumption and production), 13 (Climate action), 14 (Life below water), 15 (Life on land), 16 (Peace, justice and strong institutions), and 17 (Partnership for the goals).

CANCER SCREENINGS (Stats 2020/21)
• Over 54 210 conducted in total (with abnormalities referred accordingly).
• Conducted over 6 260 pap smears and facilitated 2 989 in partnership with the Department of Health (DoH).
• Carried out more than 20 570 clinical breast examinations.
• 8 848 Prostate Specific Antigen (PSA) tests completed and 351 done in partnership with DoH.
• Over 3 010 skin examinations using the FotoFinder Mole Analysis device took place.
• Expanded workplace screening and wellness programmes.


HEALTH SCREENING, EDUCATION AND AWARENESS (Stats 2020/21)
• Approximately 40 727 individual information and education sessions conducted with screenings.
• Over 7 560 people assessed to determine their lifestyle risk, with 2 361 glucose tests performed for diabetes.
• More than 465 900 people reached through 1 738 talks and 4 531 exhibitions with the help of 795 health promotion volunteers.
• Over 150 radio talks hosted for cancer education.
• Distributed over 71 110 information leaflets to promote health awareness campaigns.


CANSA ORGANISATIONAL PROFILE
• More than 79 700 youth reached through 402 school programmes.
• Our CANSA Helpdesk responded to over 12 680 enquiries for support and information via telephone, WhatsApp, email, website and social media.


CURRENT PLANS AND THE FUTURE
CANSA’s service and income generation is managed and deployed centrally with national teams, placed across the country. We streamline and modernise our service and fundraising efforts regularly. We have CANSA Care Centres around the country with certain CANSA Care Centres operating as ‘Virtual CANSA Care Centres’ where employees work remotely to offer services within their surrounding communities assisted by willing volunteers.


Our country’s economic recovery post COVID-19 will take a few years. The need for our normal services continues and even more patients and caregivers need help. We are aware of our duty to continue to educate South Africa about the cancer burden and find innovative ways to help lower the cancer risk, while providing support and care to the communities we serve.

Cancer Association of South Africa (CANSA)

The Pioneer Academics Opportunity Fund is the non-profit arm that allows us to stay true to our social mission. 

The Pioneer Opportunity Fund is a vital resource that allows us to extend life-changing educational opportunities to high-achieving, low-income students around the globe. Managed by our Fiscal Sponsor, Edward Charles Foundation (ECF), this fund operates under ECF’s 501(c)(3) umbrella, ensuring that your donations are tax-deductible and managed with the highest standards of accountability and integrity.

**Global Non-Profit Partners of Pioneer Academics:**

We are proud partners of leading non-profit organizations supporting high-achieving, low-income students around the world including **Questbridge**, **A Better Chance**, **Jack Kent Cooke Foundation**, **EducationUSA**, **Hali Network**, and **Ukraine Global Scholars**, among many others. 

**Why Your Donation Matters:**

- **Transform Lives**: Your contribution directly supports students who demonstrate exceptional academic potential but lack the financial resources to access co-curricular opportunities.

- **Promote Global Equity**: Pioneer Academics partners with some of the leading domestic and international NGOs that champion equal educational access for the most underserved communities.

- **Empower Future Generations**: Pioneer alumni carry their spirit of trailblazing well beyond their Research Program experience. They become leaders and trailblazers on college campuses and in their careers. 



Pioneer Academics Opportunity Fund

The Top Charities Fund supports the highest-priority funding needs among our top charities.

We find and recommend outstanding giving opportunities and publish our research to help donors give more effectively and with greater confidence.

All donations here support our Top Charities Fund. Donations to the Top Charities Fund are granted on a rolling basis to support cost-effective funding opportunities at our top charities. We use our latest research to grant the funds to the top charity (or charities) where we believe they’ll do the most good.

Learn more and view past grants at https://www.givewell.org/top-charities-fund


Photo caption: At health centers in Sierra Leone supported by Helen Keller Intl, mothers who bring their children in for twice-yearly vitamin A supplemention can also receive comprehensive counseling about birth control options that are available to them free of charge. Combining family planning and children's healthcare services benefits both mother and child. 2019.

Top Charities Fund

Help preserve the Shulgin legacy and build a global community dedicated to scientific, therapeutic, and spiritual insight.

The Shulgin Foundation honors the revolutionary legacy of Ann and Sasha Shulgin while building a vibrant future for psychedelic science, healing, and community.

From an unassuming 200-square-foot lab in Lafayette, California, Sasha Shulgin created over 150 novel psychedelic compounds, including MDMA, while Ann pioneered therapeutic frameworks that continue to guide modern psychedelic therapy. Their historic Farm—a gathering place for four decades of psychedelic research and community—stands as both a monument and a living laboratory.

Today, the Foundation is preserving this irreplaceable heritage site while fostering a global community dedicated to scientific discovery, therapeutic advancement, and spiritual exploration. Through educational programs, archival preservation, and community gatherings, we are carrying forward the Shulgins' vision of responsible inquiry and compassionate care.

Your tax-deductible donation supports:

- Preserving the historic Shulgin Farm property
- Creating accessible psychedelic education
- Archiving invaluable research materials
- Building community across generations of researchers and healers

Join us in honoring the past while creating the future of psychedelic science and healing.

Shulgin Foundation

An endowment protecting the Los Cedros cloud forest forever.

Held in the mists of the Ecuadorian Tropical Andes, a scientific station works with local communities to protect a cloud forest known as Los Cedros (“The Cedars”). The station encourages artists, educators, and researchers to connect with and learn from Los Cedros, whose walking palm trees and old growth lift racket-tail hummingbirds and critically endangered brown-headed spider monkeys into the clouds. Decades of interdependent artwork and scientific discovery from the station—including over 100 publications—factored into the 2021 [decision of Ecuador’s highest court](https://www.theguardian.com/environment/2021/dec/02/plan-to-mine-in-ecuador-forest-violate-rights-of-nature-court-rules-aoe) to ban extractive practices in the forest by upholding Los Cedros’ constitutional rights to exist and to thrive.

This ruling set a monumental precedent for worldwide Rights of Nature efforts. Yet mining companies continue to apply pressure to Los Cedros communities and Ecuadorian authorities—and if mining comes to pass in Los Cedros, it will devastate one of the most biodiverse and endemic forests in the world. Home to thousands of wildlife species, Los Cedros spans 6000 hectares of mostly primary forest habitat. There, the threatened spectacled bear builds a tree bed to feast on aguacatillo berries (tiny avocados), and the elusive jaguar has left her tracks on the banks of waterfalls. In the abundant green shadows, undiscovered fungi, insects, and orchids flourish. A glass frog hides his heartbeat under a leaf.

As one of the rare places where humans can still drink directly from cascading rivers, this refuge also protects numerous watersheds crucial to downstream communities. So, the Los Cedros Fund will prove that the station’s approach of sustainably partnering with the cloud forest and surrounding communities is best for Pachamama—all of Mother Earth, including humans—in the long term.

The Los Cedros Fund is growing an endowment for the cloud forest to be financially self-sufficient. Honoring all who’ve protected the forest for decades, the Los Cedros Fund aims to offer this new watershed of perennial support to the forest to keep artistic, educational, and scientific collaborations flowing.

We can only achieve this mission through the kindness and generosity of thoughtful donors like you.

Los Cedros Fund

Communicating the best research and data to understand big global problems and make progress against them

Poverty, disease, hunger, climate change, war, existential risks, and inequality: The world faces many great and terrifying problems. Our World in Data focuses on communicating the best research and data that helps us understand and find solutions to the world’s largest problems.


Our World in Data publishes an open-access publication where users can understand the state of the world today, where we are making progress and where we are falling behind. Through interactive data visualizations we can see how the world has changed; by summarizing the scientific literature we can understand why. We cover everything from global poverty to natural disasters, education and health, democracy; we have over 13,000 charts across hundreds of topics.


Our World in Data is free, open-source and provided as a public good. It has millions of users every month, and is cited in research and media across the world every day. This allows millions of people to understand the large problems the world is facing, and how we can solve them.

Our World in Data

Aquatic Life Institute is a 501(c)(3) non-profit focused on reducing the suffering of aquatic animals in the global food system.

Aquatic Life Institute (ALI) was founded in 2019 to address the critical and often overlooked issue of aquatic animal welfare. Recognizing that aquatic animals are the most exploited group of animals worldwide yet remain largely unprotected, ALI set out with a mission to drive systemic change and elevate aquatic animal welfare as a priority in global food systems.

Our theory of change is rooted in the belief that by influencing key stakeholders and decision makers, advancing policies, and fostering collaboration, we can drive systemic transformation for billions of aquatic animals. 

Building on this foundation, ALI has emerged as a thought leader, advocating for tangible improvements across the seafood supply chain. By engaging with key stakeholders, including corporations, certification schemes, and policymakers, we work to ensure that aquatic animals trapped in the food system receive the attention they deserve in decision-making processes relating to sustainability and food systems. 

ALI’s work is driven by evidence-based strategies and collaboration. This approach has earned ALI widespread recognition, including a 2024 Top Charity recommendation from Animal Charity Evaluators (ACE). This endorsement solidifies ALI’s position as one of the most effective organizations in the world advancing aquatic animal welfare. 

Aquatic Life Institute Inc

Founders Pledge is a global nonprofit empowering entrepreneurs to do the most good possible with their charitable giving. 

Maximize your philanthropic impact with Founders Pledge. We empower a global community of over 2,100 members, equipping them with everything needed to give effectively: from evidence-led research and expert advice on the world's most pressing problems to comprehensive infrastructure for seamless global grant-making, and a powerful network for collaboration. Together, we've already channeled over $1.5 billion to high-impact causes globally, tackling critical issues like climate change, global health, and emerging existential risks. 

When you donate through every.org today, you're joining this proven movement, and our unique funding model ensures 100% of your contribution goes directly to charity, as our operational costs are generously covered by a dedicated community of philanthropists.

Founders Pledge

Developing the roadmap for a sustainable, secure, and just global protein supply 🧫🌱


Check out what your support makes possible at gfi.org/your-impact. 

The Good Food Institute (GFI) is a global network of nonprofit organizations developing the roadmap for a sustainable, secure, and just protein supply. Industry alone will not meet this challenge at the scale or speed we need. GFI is accelerating the transformation of the food system by identifying solutions and mobilizing resources to make alternative proteins the default way meat is made.

GFI is a network of nonprofits around the world strategically based in the most critical economies for alternative protein advancement. In Asia, Europe, Brazil, India, Israel, and the U.S., GFI’s teams are mobilizing the international community to use markets and technology to replace harmful practices with ones that are better for the climate and biodiversity, for food security, and for global health.

GFI’s Focus
As a nonprofit, GFI is uniquely positioned to accelerate the transition to alternative proteins by focusing on three programmatic priorities:

-Cultivating a strong scientific ecosystem | GFI’s science and technology teams map out the most neglected areas that will allow alternative proteins to compete on taste and price. GFI meets these challenges by developing open-access research and resources, educating and connecting the next generation of scientists and entrepreneurs, and funding research that benefits alternative protein development across the sector. 

-Influencing policy and securing government funding | GFI’s policy teams ensure that alternative proteins are a part of the policy discussion around climate change mitigation and global health. In every region where GFI has a presence, teams advocate for government funding and incentives to transition to alternative proteins and are paving the way for the approval of novel proteins such as cultivated meat.

-Ensuring industry prioritizes alternative proteins | GFI’s corporate teams are creating a transformation of our global meat supply. GFI works to replicate past market transformations by showing companies of all sizes, from startups to multinational corporations, how alternatives to animal products can be profitable while meeting environmental, social, and governance goals.

Reimagining meat
The very real threats of climate change, global food insecurity, antibiotic resistance, and pandemics require us to imagine a different future of food. Alternative proteins are the solution that will securely and sustainably feed the world.

GFI’s global community of scientists, policy experts, and corporate specialists are creating a world where alternative proteins are no longer alternative.



The Good Food Institute

Cuddles Foundation nourishes children in their fight against cancer. Because #Foodheals



**Feed Children. Starve Cancer.**

Every year, approximately 76,000 children in India may develop cancer, with 58% of them being severely malnourished at the time of diagnosis. For these children, nutrition can mean the difference between life and death. Every child deserves a chance at a cure, and we are here to make that happen.

At Cuddles Foundation, we partner with over 40 government and charity cancer hospitals to support children through our FoodHeals program. Our mission is to ensure that children undergoing cancer therapy receive comprehensive nutritional support. This includes access to trained clinical pediatric nutritionists, expert dietary counsel, supplements, hot meals, monthly ration baskets, and caregiver support. Good food helps the medicine work!

This multi-pronged approach tackles a simple but often ignored aspect of a child’s successful recovery from cancer. While undergoing treatment, it is essential that children have freshly prepared, nutritious food in sufficient quantity and don't stay hungry for long periods. The impact of our work is evident. When part of the FoodHeals Program, 82%* of patients improved or maintained their nutritional status, despite cancer therapy like chemotherapy or radiation.

Additionally, 96% of children followed up* on their treatment plan when nutrition was a part of it, demonstrating the program’s effectiveness. Besides the love and affection of our patients, their families, and our supporters, we’ve won some prestigious awards along the way. This includes the National Award for Child Welfare (2015-16), the Akshaya Patra and UN Global Compact Award (2018) and most recently we received the Global CSR & ESG Awards 2024 - Top 10 Best NGOs of the Year (2024).

Join us in our mission to nourish hope and fight childhood cancer. Your support can make a world of difference.

**As per Cuddles annual impact statistics 2023-24*
**Follow-up treatment rate: Patients who returned for a second visit or continued treatment when nutrition was a part of it.*

Cuddles Foundation

Animal Charity Evaluators helps people help the most animals.

Do you want to help animals but find it hard to decide how? That's understandable. Trillions of animals suffer every day on farms and in the wild. The problem is vast and complex, but people around the world are making a difference.

Animal Charity Evaluators (ACE) is a 501(c)(3) nonprofit registered in the United States dedicated to finding and promoting the most effective ways to help animals. We do this by evaluating and recommending high-impact charities, awarding strategic grants to promising projects, and raising critical funds for the animal advocacy movement. Our ultimate goal is to educate and empower individuals and organizations to make a significant and lasting positive impact on the lives of neglected animals who are often forgotten. ACE envisions a future in which no individual is given less than full moral consideration on the basis of any morally irrelevant feature of their identity, including species membership.

ACE has a unique and influential role within the effective animal advocacy movement. Our global team is composed of experienced professionals in animal advocacy, effective altruism, and research methodology. To date, we have rigorously evaluated 85 charities that work to end factory farming and create meaningful change for farmed and wild animals, and recommended 38 high-impact organizations as effective giving opportunities. Through our strategic grantmaking, we have distributed nearly $20 million to our Recommended Charities and promising advocacy projects around the globe. Since ACE began tracking this metric in 2014, we estimate that we’ve helped to influence at least $81 million within the animal advocacy movement. Over the years, we have built strong partnerships with organizations and researchers, amplifying our collective efforts to improve the lives of as many animals as possible. 

Join us! Together, we can build a future that's kind to *all* species.

Animal Charity Evaluators

For cancer information, call 1-800-227-2345 anytime, day or night, or visit www.cancer.org

The American Cancer Society is leading the fight for a world without cancer. 

We’re finding cures and doing so much more. 

The ACS supports patients with free lodging near hospitals, free rides to treatment, and our live 24/7 cancer helpline.  

We’re providing information, tools and services to help people cope with the challenges and questions that come with a cancer diagnosis.  

We’re making breakthroughs in research and urging lawmakers to improve access to care.

When it comes to cancer, we are the only organization attacking from every angle.

American Cancer Society

Eliminating obstacles on the path to the comprehensive medical control of aging and age-related disease.

Longevity Escape Velocity (LEV) Foundation exists to conduct and inspire research to proactively identify and address the most challenging obstacles on the path to the widespread availability of comprehensively effective treatments to prevent and reverse human age-related disease.

Longevity Escape Velocity Foundation

The Taube Center is committed to strengthening the bonds between Jews and Jewish communities worldwide.

The Taube Center provides innovative educational programs and extensive resources with the aim to enrich Jewish life in Poland and to connect Jews from around the world with their Eastern European heritage. The Taube Center has developed an array of programs, which serve the Jewish communities in Poland and engage audiences from around the world. Constantly expanding its network of partner organizations, the Center has recently become a member of the European Association for the Preservation and Promotion of Jewish Culture and Heritage. Taube Jewish Heritage Tours Taube Jewish Heritage Tours is a mission-driven, on-the-ground Jewish heritage tour service based in Poland. Our professional team of academics, guides, educators, and community leaders provide meaningful and engaging customized tours of Poland's multicultural landscape, infusing each encounter with illuminating personal stories and insights from those engaged in Polish Jewish life and committed to the preservation of Polish Jewish heritage. TJHTalks Series Having suspended our flagship program, Taube Jewish Heritage Tours, we launched TJHTalks in April 2020 as an interactive way to maintain contact with past and future tour participants and to broaden the Center's audience. Yerusha: Professional Development Program The year-long program, now in its second year, distinguishes itself from other Jewish professional development opportunities in that the operative language is Polish and all workshop facilitators are based in Poland. Resource and Educational Materials The Taube Center has developed a sophisticated set of resource materials in several languages that support our educational programs and are especially valuable for our study tour program. Our publications have been disseminated at the POLIN Museum and the Galicia Jewish Museum and through Polish embassies and cultural institutions around the world.

Taube Center for Jewish Life & Learning

We are a think tank dedicated to figuring out the best ways to make the world a better place.

Rethink Priorities is a think-and-do tank that informs nonprofits, funders and policymakers about how to most effectively improve the lives of humans and animals—both now and in the future.

Through rigorous analysis and strategic action, we identify high-leverage interventions across animal welfare, global health and development, and other neglected but promising areas. We maintain the highest standards of rigor while equally valuing curiosity and open-mindedness, working to drive evidence-based change where it's needed most.

If you'd like to support one of our fiscally sponsored projects (e.g. Epoch), you can give via Every.org, and let us know how to allocate your gift at info@rethinkpriorities.org.

Rethink Priorities

Al-Mawrid United States is a nonprofit religious organization based in Carrollton, TX. It received its nonprofit status in 2015.

Al-Mawrid is a foundation for Islamic research and education established by Javed Ahmed Ghamidi that emphasizes on learning Islam purely through its established sources, Quran and Sunnah, without external factors that have influenced the Muslim thought over the last several centuries.

Javed Ahmed Ghamidi formed Al-Mawrid back in 1983 in Lahore, Pakistan in order to propagate Islam as instituted by prophet Muhammad (peace and blessings be upon him). Al-Mawrid U.S. was established in 2014 in order to expand the reach of Ghamidi’s effort. In 2019, Al-Mawrid U.S. took on the initiative of establishing the Ghamidi Center of Islamic Learning in Dallas, Texas as a formal educational institute.

Since inception, Al-Mawrid’s aim has been to conduct research, educate people, and disseminate Islam based purely on Quran and sunnah, freeing it from external influences that have gradually clouded the religious thought of Muslims over the last 14 centuries.

Our Mission
Our mission is to teach people how to explore, understand, discuss, and practice Islam based on reason, rationality, and objective thinking.

Our Values

KNOWLEDGE
Teach Islam as a form of knowledge rather than as a creed.

TOLERANCE
Encourage students to explore faith in a welcoming, open, and an inquisitive manner.

OBJECTIVITY
Equip students with tools necessary to understand Islam based on evidence from Quran and sunnah.

DIVERSITY
Be open to all truth seekers without gender, age, religion, or any other discriminating factors.

Ghamidi Center Of Islamic Learning

Pediatric malnutrition treatment – reimagined for scale.

Taimaka has reimagined pediatric malnutrition treatment to make it **more cost-effective and scalable**. We’ve developed a malnutrition treatment model that is:

1. 53% cheaper than legacy approaches and:
2. Leverages digitally-enabled community health workers (CHWs) to deliver care to the most vulnerable communities. 

So far, we’ve used our model to treat 6,000+ children out of existing government hospitals in northeastern Nigeria with world-class recovery rates of 95%+. Our track record has led charity evaluators like [Founder’s Pledge](https://www.founderspledge.com/funds/global-health-and-development-fund) to identify us as one of the most cost-effective nonprofits in global health, with a [cost-per-life saved of $1,644](https://docs.google.com/spreadsheets/d/16czhbk2xjA1EkhQxebnTV_49cwVC9XYFE23Jal2Yhu4/edit#gid=0). Over the next five years, we’re on track to expand our program to treat tens of thousands of children, while helping governments revamp their outdated programs so that they can double the number of children they reach. 

Read more at taimaka.org. 

Taimaka

MAPS works towards a post-prohibition world by advancing research, changing policies, and shaping culture. 

Since our founding in 1986, the Multidisciplinary Association for Psychedelic Studies (MAPS) has been the leading organization building the movement to foster evidence-based approaches to psychedelics and the people who use them. When used safely and responsibly, psychedelics have the potential to promote personal growth and well-being and treat various mental health conditions. Three pillars guide our efforts: advancing research, changing policies, and shaping culture. 

[Advancing Research](https://maps.org/advancing-research/)

MAPS spent decades developing MDMA-assisted therapy for the clinical utilization of psychedelic-assisted therapies. With the road paved for the next generation of research and drug development, MAPS now stewards the research landscape we helped cultivate.

We are dedicated to fostering new research directions that prioritize public benefit, supporting international researchers and pilot programs, and ensuring the accessibility and culturally appropriate integration of psychedelics as a tool for individual and community wellness. We center research that contributes to knowledge in the public domain.

[Changing Policy](https://maps.org/changing-policy/)

The cultivation, use, and trade of psychoactive substances — including psychedelics — has been a consistent aspect of human history, but prohibition, criminalization, and militarization — and their inherent oppression — have led to drastic consequences. The ongoing, global War on Drugs has been justified by bad science, racism, and fear for too long: it has led to mass incarceration; erosion of civil liberties; ecological damage; economic waste; and the public health polycrisis of adulteration, poisoning, and overdose. Many of these harmful effects have disproportionately impacted the most historically exploited and oppressed communities. Consequently, we believe societies worldwide have an obligation to account for and repair those harms, to the extent possible. 

MAPS envisions a post-prohibition future based on Consciousness, not Criminalization.

[Shaping Culture](https://maps.org/shaping-culture/)

For psychedelics to be most safely integrated into society, we need to be honest about the implications. MAPS recognizes the importance of a comprehensive understanding of their risks and potential benefits, teaching people how to navigate altered states of consciousness and how policies impact individuals and communities. 

We create cutting-edge education for professionals and the public, provide expert support for the psychedelic and drug policy movement, and convene people who share our vision—all to lay the groundwork and create the guardrails necessary for responsible social transformation. 

As psychedelics become more mainstream and an increasing number of people seek to use them for healing and personal growth, we are more dedicated than ever to making resources available for people and communities to safely and responsibly integrate psychedelics into medical, legal, and spiritual contexts.

MAPS

SEF designs and implements state-wide training programs for teachers & principals, to make learning more engaging & impactful.

**About Us**

Founded in 2013, **Simple Education Foundation (SEF)** is dedicated to transforming education in India’s government schools by empowering teachers to create meaningful and impactful learning experiences. Our work began with **Prayog Shala**, a community learning center in Delhi, and has since expanded across multiple states, impacting over 160,000 teachers and students.

At SEF, we collaborate with state governments to design and implement **statewide teacher training programs**, focusing on sustainable, region-specific solutions. We co-design frameworks with educators to ensure that these programs are scalable and self-sustaining. Through our programs, we aim to bridge the gap in education quality between government and private schools, equipping teachers with the skills and support needed to provide excellent education to all children.

With our latest initiative, **Teachers for Tomorrow**, we’re preparing the next generation of educators to lead classrooms that inspire learning, growth, and social change. Our mission is to reach **1 million teachers by 2028**, ensuring that every child in India has access to high-quality education.

**Our Mission**

At SEF, our mission is to empower **1 million teachers by 2028**, transforming classrooms across India and ensuring every student receives a high-quality education. We aim to equip teachers to become catalysts for change, creating equitable learning environments where every child can thrive, regardless of their socio-economic background.

**Our Vision**

Our vision is clear: every child in India should have access to high-quality education that paves the way for a brighter future. We are committed to breaking down barriers to education, ensuring that no child’s potential is limited by their circumstances.

**Our Programs and Journey**

In 2016, SEF took a significant step by partnering with the state government of Jammu & Kashmir to launch a teacher training program for over 85,000 teachers. This success marked a turning point, allowing us to dive deeper into our mission of teacher development and educational transformation.

That same year, we started working in Uttarakhand, where we established a community learning center in the village of Gular. This program has since evolved into several initiatives, including the Sashak Prathamik program, which today works with five primary schools in the Tehri Garhwal region. We also collaborate with the Narendra Nagar block to develop and facilitate their mentor teacher coaching and training programs.

In 2017, we launched our Centers of Excellence program in Delhi, working with seven government primary schools. Today, we continue to partner with three of these schools, focusing on enhancing learning outcomes and teacher effectiveness.

By 2021, SEF had extended its partnership with the Delhi government and SCERT to design and implement a competency-based teacher training program aimed at strengthening teacher competencies and the mentor teacher program across the state.

This year, we expanded our work to include collaborations with the state governments of Uttarakhand and Punjab. Our efforts focus on delivering comprehensive teacher development programs that include both training and coaching, developed in close partnership with block and district resource officials.

Our newest initiative, Teachers for Tomorrow (formerly Future Teacher Program), launched in 2022, is designed to equip aspiring teachers with the skills and mindset necessary to become exceptional educators. Under this program, we aim to ensure that these future educators are fully prepared to lead classrooms that inspire and nurture the next generation.

**Our Achievements**

•	Impacted more than 160,000 teachers across Delhi, Uttarakhand, Punjab, and Jammu & Kashmir.

•	Established eight government partnership schools, setting new standards for quality education.

•	Team members and individuals associated with SEF have been selected as fellows with prestigious global organizations such as Acumen, the Dalai Lama Program, WISE Qatar, Teach for All, and more.

•	SEF has participated in and presented at national and international conferences, contributing to thought leadership in the field of education through research papers and findings.

•	Recognized as a “Great Place to Work” for three consecutive years.

**Future Plans**

Looking ahead, SEF is focused on scaling our impact across multiple states and programs. Currently, under the Centers of Excellence program within our Government Partner School Program, we work with eight schools in Uttarakhand and Delhi. Our State In-Service Teacher Training Programs span Delhi, Punjab, and Uttarakhand, and in 2024, we aim to cumulatively impact over 1.5 lakh teachers through workshops, coaching programs, training sessions, and the provision of tools and resources.

Through our Teachers for Tomorrow program, which focuses on pre-service teacher education, we will work with over 2,000 aspiring teachers across several institutes in Delhi. This year, we also plan to pilot innovative programs that will help define and refine our strategy for developing the teachers of the future.

Our journey has been bolstered by the support of several esteemed organizations, including the Wipro Foundation, InfoEdge, Max India Foundation, Anu Agha and Meher Padamji Family Office, the Bikchandani Family Office, Padmini, V&A, Forest Essentials, Boston Consulting Group, and others. We have also built strong partnerships with government agencies across Jammu & Kashmir, Delhi, Uttarakhand, and Punjab.

As we move forward, SEF remains committed to building sustainable, scalable solutions for India’s education system, driven by the belief that every child deserves access to high-quality education.

**Looking Forward**

As we look ahead to 2028, SEF’s goal is to continue expanding our impact, reaching 1 million teachers and transforming classrooms across India. By strengthening teachers, we strengthen the future of our children and our nation.

**For more information, visit our website at www.simpleeducationfoundation.org.**

Simple Education Foundation

Prevention, control and treatment of malaria and other communicable diseases among vulnerable populations.

Malaria Consortium US, Inc. (MC-US) is a registered 501(c)(3) public charity and shares the mission of Malaria Consortium, a globally recognized organization committed to reducing deaths and illnesses caused by malaria and other preventable and treatable diseases across Africa and Asia.

Our mission is to save lives and improve health in Africa and Asia through evidence-based programs that tackle malaria and other priority diseases while advancing universal health coverage (UHC). In the US, we build partnerships with foundations, donors, and philanthropic organizations to ensure that every contribution makes a lasting impact for those most in need.

As a leader in malaria control and elimination, our work focuses on interventions such as seasonal malaria chemoprevention (SMC), malaria vaccines, disease surveillance, and integrated child health services. We work in collaboration with governments, communities, and health systems to improve access to essential healthcare and strengthen delivery of services in underserved and hard-to-reach areas.

As a leader in interventions such as chemoprevention and vector control, we rely on evidence and our expertise to deliver established interventions, influence other effective interventions and guide new strategies to reduce the burden of malaria, pneumonia, dengue, malnutrition and diarrhea. We work with communities and all levels of the health system to improve access to and demand for primary healthcare services and overall quality of care.

Our tailored interventions seek to improve equity by providing quality, affordable health services to marginalized populations (particularly women and girls and those living in hard-to-reach areas). To ensure barriers to achieving UHC are addressed and to encourage sustainability, we work closely with governments to integrate our programs within existing health systems and structures in the countries in which we work.

We promote disease surveillance as a core intervention to engage communities to improve the quality and accessibility of routine health information by using digital tools and approaches that strengthen the linkages between case-level data and national health information systems. We combine capacity development at community level with the use of innovative tools and platforms to enhance local capabilities to interpret and use these data most effectively.

All of our work is informed by our core values: accountability, integrity, dignity and equity.

Malaria Consortium

Support our mission to ensure trustworthy and safe AI at Apart Research.

We are active contributors and enablers of AI safety research. Our mission is to minimize the risks posed by large-scale AI applications to society. To this end, we conduct research to develop safer AI and nurture talent for AI safety research roles. We organize international research sprints focused on safety topics and support talented researchers in transforming their work into fully published articles.

Apart Research

The Fungi Foundation is a global organization that works for the Fungi, their habitats, and the people who depend on them.

Launched in 2012, the Fungi Foundation is the first NGO dedicated to the fungi kingdom. Since its inception, it has achieved numerous milestones while dedicating itself to exploring the fungi world in view of increasing knowledge of their diversity, educating about their applications, and recommending public policy for their conservation. As part of our ongoing 3F initiative, the foundation played a key role in enabling Chile to become the first country in the world to include protection of fungi in its environmental legislation. More recently, the foundation proudly announced the Fantastic Fungi Education Curriculum, the world's first mycological set of courses designed for schools.

In short, the Fungi Foundation envisions a healthy planet in which Fungi are recognized, protected, and embraced as the interconnectors of nature; a mission that would be impossible without the essential support of our kind, engaged donors.

Fungi Foundation

The IWM is a non-profit institution that promotes intellectual work and enables encounters of people around ideas. 

The Institute for Human Sciences (IWM Vienna) is an institute of advanced studies in the humanities and social sciences founded in 1982. We promote intellectual exchange across disciplines, between academia and society, and among regions that now embrace Eastern, Central and Western Europe, the Global South and North. We aim to reframe larger questions of academic debate and public interest that address today's complex challenges. We believe that sustained intellectual work and its broad dissemination is essential to a humane future of open, just, and sustainable societies. 

Institut für die Wissenschaften vom Menschen (IWM)

CETI is a nonprofit org applying advanced machine learning and gentle robotics to listen to and translate whale communication. 

Founded in 2020 as a TED Audacious Project, the organization’s science team is made up of the world's leading artificial intelligence and natural language processing experts, marine biologists, cryptographers, linguists, roboticists and underwater acousticians. CETI’s research is taking place off of the island of Dominica in the Caribbean.

In the late 1960s, scientists, including Dr. Roger Payne, a principal advisor of CETI, discovered that whales sing to one another. His recordings, Songs of the Humpback Whale, sparked the “Save the Whales” movement, one of the most successful conservation initiatives in history. The campaign eventually led to the Marine Mammal Protection Act that marked the end of large-scale whaling and saved several whale populations from extinction. 

All this by just hearing the sounds of whales. Imagine what would happen if we could understand them?

WHY WHALES 
Sperm whales specifically share traits strikingly similar to humans. They live in matriarchal and multicultural societies and share dialects and strong multigenerational family bonds. Sperm whales have the largest brains of any species and have higher-level functions such as conscious thought and future planning, as well as speech and feelings of compassion, love, suffering and intuition. Their vocalizations, among the loudest animal sounds on the planet, have a Morse code-like structure that shares the hallmarks of a highly-evolved language. Our understanding of these animals and their dialects is still in its infancy. Only in the last fifteen years have we begun to learn how some of their vocalizations are used for communication.  
WHAT CETI IS DOING
CETI is:
-Developing non-invasive robotics to listen to a population of whales in the Caribbean and put their sounds into context.
-Deploying a “Core Whale Listening System,” an innovative hydrophone array, underwater robotic gliders, custom bioinspired whale tags and other technology to gently study the whales.
-Building on substantial data on the whales’ sounds, social lives, and behavior already obtained by the Dominica Sperm Whale Project. 
-Creating a bespoke, big-data pipeline to examine the recorded data and decode it using advanced machine learning, natural language processing and data science.
-Publishing a series of academic papers beginning with the CETI roadmap.
-Collaborating with the National Geographic Society, including their Exploration Technology Lab, and amplifying the project across National Geographic’s storytelling and education channels.
-Implementing community-based programs like the Dominica Marine Conservation Fellowship, a community-based 10-month multi- module training program for young Dominicans interested in marine science, that was developed in partnership with National Geographic.
-Launching various communications projects to tell CETI’s story including a public interface for the citizen science community, resources for educators and children and arts programs.

IMPACT
Now, for the first time in history, it’s possible to use artificial intelligence to identify and interpret deep structure within animal communication. Using these technologies, CETI is building on the legacy of the “Save the Whales” movement with the goal of having an impact by contributing the following:
Interspecies Communication - A new data set of unprecedented size to the rapidly expanding field of interspecies communication and a roadmap of how humans could translate the communication of any other species
Marine Biology - A substantive contribution to the field of whale research within marine biology that opens gateways for future research initiatives. 
Policy - New information about whales that can bolster policy efforts to protect marine mammals and ocean habitats. Policy advances in this area are crucial as six out of the 13 “great” whale species (the largest whales) are still endangered (World Wildlife Federation). To ensure impact in this area, CETI plans to build out policy campaigns and initiatives. 
Perspective - It is widely endorsed that connectivity with nature can improve mental health. By sharing its journey and findings with the public, CETI hopes to contribute to a feeling of increased wonder and connectedness to whales and the ocean that can inspire action. CETI will build out arts and childrens’ initiatives in support of this impact goal.
Conservation - CETI’s first phase of research is taking place in Dominica in the Caribbean, a region that is one of the world’s greatest centers of diversity. By carrying out its research in partnership with local stakeholders, CETI hopes to contribute to regionally-led research and conservation efforts.

HOW CETI IS SUPPORTING DOMINICA
-CETI’s capacity-building initiative, Dominica Marine Conservation Fellowship is a 10-month, nine module training program for young Dominicans interested in marine science) in partnership with National Geographic.  The program has three 2022/2023 fellows and partnerships with the Dominica National Youth Council, Dominica State College and Dominica’s Ministry of Education. The program’s curriculum (co-created with National Geographic) includes modules on marine science, scientific research/techniques, water and vessel skills and storytelling and leadership among other topics.
-All research and findings by CETI in Dominica are all open-source and will be available for Dominica. The organization’s sailing research vessel (CETI-1), a Rigid Inflatable Boat (CETI-2) and Dominican made boat (CETI-3) are in operation in Dominican waters; these boats along with other CETI equipment will be donated to the local entity at the completion of the project.
-A temporary field station has been established in Dominica and has the capacity to host 10-12 researchers, fellows and students. In the long-term, CETI plans to build a permanent field station in Dominica 
-In 2023, CETI will continue local engagement and presentations with primary and secondary schools, development of video content for use in classrooms, collaborations with local artists and collaborations with local stakeholders such as marine and dive operators, civil society organizations and schools.



Project CETI

ARC is a non-profit research organization whose mission is to align future machine learning systems with human interests. 

See our website for more info about our work. 

Alignment Research Center

Nonpartisan nonprofit dedicated to empowering people with voting methods that strengthen democracy.

Founded in 2011, The Center for Election Science is a national, nonpartisan nonprofit dedicated to helping the world use better election systems. We study and advance alternative voting methods, with an emphasis on a method called approval voting. We’re passionate about voting methods because the collective decisions we make through voting dramatically impact our day-to-day lives. Smarter collective decisions, whether in government or in private organizations, promise to provide us all with a better quality of life.

The Center for Election Science

ConnectMyVariant's mission is to end hereditary disease by bringing families together.

ConnectMyVariant is an educational health-focused 501(c)3 nonprofit organization that supports individuals and families with hereditary disease in their early detection and prevention efforts. We provide unique value by leveraging our evidenced-based family connection protocols to help people identify other at-risk relatives and help those relatives access genetic testing so that they can get optimal medical care. ConnectMyVariant brings people with the same genetic risk together through our variant database and community engagement events to share experiences and find common ancestors. ConnectMyVariant also works to increase awareness of the benefits of family outreach among physicians, others who provide prevention care, and the broader genealogy community.
 
Our key activities are:

- Working with patients to implement personalized family outreach plans
- Interactive educational workshops about sharing information on inherited disease risk
- Variant specific family reunions to share stories and plan outreach to cousins
- Genealogy assistance to help connect individuals in variant groups
- Individual equity and inclusion grants for family and community outreach

Need and Impact:
When hereditary disease risk is known, family outreach has been proven to be the most effective and cost-effective intervention for early detection and prevention. This family outreach, also known as cascade testing, is recommended by multiple guidelines. Despite overwhelming evidence, family outreach assistance is not reimbursed by insurance or integrated into healthcare. Many people suffer and die from hereditary disease that could have been prevented or caught early.
 
We have shown that our strategies to encourage family outreach can act as a communication multiplier. Our pilot research at the University of Washington showed that this approach enhanced patient experience, was considered ethical, and was appreciated by newly identified relatives. Our approach is low-cost and is 25 to 50 times more effective than awareness and education interventions that target the general population.

Equity and Inclusion:
ConnectMyVariant is committed to being a leader for equity, diversity, and inclusion in hereditary disease prevention. ConnectMyVariant’s goal is to spread awareness among all individuals and families about inherited disease risk. All project staff, participants, and partners in ConnectMyVariant have an equal voice in developing innovative ways to improve hereditary disease outreach and prevention for all people. By fostering a diverse and inclusive community, we can provide knowledge and opportunities that have been historically inaccessible to millions of people.

ConnectMyVariant

FLI catalyzes and supports research and initiatives for safeguarding life and developing optimistic visions of the future.

To catalyze and support research and initiatives for safeguarding life and developing optimistic visions of the future, including positive ways for humanity to steer its own course considering new technologies and challenges.

Future of Life Institute

Spritely Institute builds, researches, and standardizes networked technology which put people and communities first.


Centralized social media is harmful to society. We are building a gatekeeper-free decentralized system. Our mission is “social media done right”, to put people in control of their own identity and build the technology that would enable a shift to collaborative and intentional security models prioritizing active consent. To accomplish this, we will build a new architecture for the internet: removing the necessity of client-server architecture, replacing it with a participatory peer-centric model.

Spritely’s technology is being released as free and open source software aiming for multiple programming language implementations and eventual open standardization. All of our work, ranging from decentralized identity, peer-to-peer user agents, decentralized social networks, encrypted and portable storage, and distributed object programming infrastructure is being built to enable a gatekeeper-free path where users and content are not tied to a specific server.

Spritely Networked Communities Institute

We do foundational mathematical research to ensure smarter-than-human artificial intelligence has a positive impact.

The Machine Intelligence Research Institute is a research nonprofit studying the mathematical underpinnings of intelligent behavior. Our mission is to develop formal tools for the clean design and analysis of general-purpose AI systems, with the intent of making such systems safer and more reliable when they are developed.

The field of AI has a reputation for overselling its progress. In the “AI winters” of the late 1970s and 1980s, researchers’ failures to make good on ambitious promises led to a collapse of funding and interest in AI. Although the field is now undergoing a renaissance, overconfidence is still a major fear; discussion of the possibility of human-equivalent general intelligence is still largely relegated to the science fiction shelf.

At the same time, researchers largely agree that AI is likely to begin outperforming humans on most cognitive tasks in this century. Given how disruptive domain-general AI could be, we think it is prudent to begin a conversation about this now, and to investigate whether there are limited areas in which we can predict and shape this technology’s societal impact.

Researchers at MIRI tend to be relatively agnostic about how the state of the art in AI will change over the coming decades, and how many years off smarter-than human AI systems are. 

Machine Intelligence Research Institute

Terra Praxis designs and implements strategies that leverage science, technology and energy innovation for a prosperous planet

We co-founded TerraPraxis to design and implement strategies that leverage science, technology and energy innovation for a prosperous planet. Our mission is to innovate and accelerate scalable, equitable solutions for unsolved areas of the climate challenge. 

Our special focus is on enabling high-impact rapid transitions for neglected parts of the decarbonization challenge. 

We work with an extensive global network to define, incubate and initiate scalable strategies that fulfil the twin missions of prosperity and decarbonization. 

Terra Praxis

North America’s nonprofit that documents and protects fungi and their habitats through mobilizing community scientists.

FUNDIS is working to protect fungal diversity through conservation, education, and community engagement for a well-documented fungal world. We envision a world in which the fungal kingdom is fully documented, appreciated and protected.

FUNDIS is a nonprofit designed to document and protect fungi and their habitats across North America. Our goals are to help create a detailed inventory of fungal diversity across continental regions and ecosystems, identify key ecological interactions, contribute to the broader scientific knowledge of fungal ecosystems, and execute conservation strategies that actually include our beloved Fungal Kingdom. 

We exist to remedy the lack of knowledge about Kingdom Fungi due to chronic underfunding. We have 38 staff, hundreds of volunteers, and thousands of people rooting us on. 

Please visit https://fundis.substack.com/ to sign up for our newsletter. Invite your friends to follow us, too. We can't protect fungi without community.

Fungal Diversity Survey (FUNDIS)

A policy shop working to implement the civilizational low-hanging fruit.

Balsa Research is a nonpartisan 501(c)(3) non-profit focused on crafting shovel-ready policies that actually address core underlying human needs. We model issues, draft viable legislation, commission academic studies, spread ideas, and work to enact change.

Balsa will focus initially on some combination of four fronts: Repealing the Jones Act, Reimagining NEPA, ensuring housing gets built where people want to live, and protecting against the risk that AI will cause human extinction.

We take a full stack approach to policy:
1. Model the world. Find improvements that balance viability with physical impact.
2. Compile options into Official Policy Binder and Official Solutions Website.
3. Commission proper academic work to credibly quantify impacts on all fronts.
4. Use this as an opportunity to run experiments and learn more.
5. Draft model legislation using learnings.
6. Spread the world via media and writing.
7. Lobby. Pitch members of Congress and their staff. Do the work. Find champions.
8. Start small if necessary. Wins beget wins.


Balsa Policy Institute Inc.

Our School's global impact would not be possible without the crucial support of our community of committed donors and friends. 

The London School of Hygiene & Tropical Medicine (LSHTM) is renowned for its world-leading research, postgraduate studies and continuing education in public and global health.

With your help, we can increase the number of scholarships we are able to offer. We receive thousands of applications every year, with funding only available to support a small number. 

Our diverse student body is what makes our community so special. Each year, your support funds our LSHTM Fund Scholars, enabling exceptional students to study at our School. We receive thousands of applications every year, with funding only available to support a small number. Without support, many brilliant students like this year's LSHTM Fund Scholar, Judy Baariu (MSc Public Health for Development, 2023) would not have been able to study with us.

LSHTM has over 3,500 staff conducting research in more than 100 countries, with core hubs in London and at the MRC Units in The Gambia and Uganda. Our outstanding, diverse and committed staff make an impact where it is most needed - deploying research in real time in response to crises, developing innovative programmes for major health threats, or training the next generations of public and global health leaders and researchers.

We help shape health policy and translate research findings into tangible impact. We are uniquely placed to lead on transformative approaches to global health and have 120 years of experience tackling big challenges. We are focused on finding new solutions to complex problems and acting upon this knowledge.

We work in collaboration with friends, partners, and supporters to achieve large-scale, long-term impact. Researchers at LSHTM explore all aspects of health challenges, from fundamental laboratory science to policy appraisal and analysis, encompassing statistical, clinical, laboratory, epidemiological and social science research globally.

Our aim is to build strong and dynamic leadership, push the frontiers of knowledge and make an impact where it is most needed. Philanthropy helps us achieve our mission; to improve health and health equity worldwide; working in partnership to achieve excellence in public and global health research, education and translation of knowledge into policy and practice.

London School of Hygiene & Tropical Medicine

We want to make life better for wild animals.

We are dedicated to finding evidence-backed ways to improve the lives of animals in the wild.

We depend on individual donors to help us make life better for wild animals. To a small nonprofit working hard on a big problem, your support is more crucial now than ever!

Wild Animal Initiative

Promoting more innovation and entrepreneurship to help address the challenges faced by wheelchair users.

Karim Slaoui was born in Belgium in 1987. After a thesis in applied mathematics to forecast the impact of tsunamis on the coastline, he launched Take Eat Easy, a food delivery company by bicycle, pioneering in South Europe. Next, he started the venture Cowboy, promoting urban cycling.
Karim was driven by optimism and innovation.

Karim was obsessed with ‘equality of opportunities’. He encouraged youngsters to be ambitious and to follow their dreams while pursuing an engineering degree. He was also involved in charities dedicated to help underprivileged teenagers in France to choose wisely for their future. With his Moroccan name, he faced prejudices and he was determined to change biased mindsets.

In 2018 Karim wanted to run a marathon but had something odd in the knee. By the end of the year, he was diagnosed with a synovial sarcoma. After 5 years of experimental treatment in 3 different countries, surgeries, and other fights, he became paralyzed because of a metastatic tumor in his spine. He lost the ability to walk and to move from the chest down.


His wife Aurore Balsan and he discovered the lack of innovation in addressing the challenges faced by wheelchair users. Before his death on September 29th 2023, Aurore Balsan, his wife, and Moncef Slaoui, his father, committed to pursue his dream and vision of promoting more innovation and entrepreneurship to help address the challenges faced by wheelchair users.

Karim Slaoui Fund

We empower animal advocates with research, analysis & strategies that maximize their effectiveness to reduce animal suffering.

We conduct essential research, maintain an online research library, and directly support advocates and organizations in their work to save lives. The range of data we offer helps our movement understand how people think about and respond to advocacy, providing advocates with the best strategies to inspire change for animals.

Our Original Studies are carefully selected, designed, and conducted to provide actionable and insightful data for the animal protection movement. Our research prioritization process helps us identify studies that have a high potential impact for animals, and our commitment to transparency and rigorous methodology ensures that our studies are of the highest quality. Our studies have been covered in hundreds of publications across animal advocacy circles as well as in mainstream media, and have been used by animal advocacy groups worldwide.

The Faunalytics Library is completely free, and houses summaries of over 4,000 peer-reviewed research articles, public opinion surveys, and blog posts offering deep analysis on every animal issue you can think of. It’s the world’s biggest collection of opinion and behavior research about animal issues, and it’s presented with an emphasis on effectiveness, readability, and useability. Sign up for our email alerts and you’ll get weekly or monthly updates on the latest research we cover, delivered straight to your inbox.

Get a comprehensive overview of a particular topic area by exploring our Faunalytics Fundamentals, a series that provides infographics and visualizations of data to help you get informed and stay informed. The Fundamentals series has everything you need to get started or update your knowledge in a familiar area, and the visuals are highly shareable beyond an advocacy audience.

Have a research question that you don’t know how to solve? Want to dive deep into a particular issue but don’t know where to start? Just ask us! Faunalytics’ Office Hours give you the opportunity to connect with us directly and get one-on-one help with research design, strategy, and general knowledge questions. We also engage in select partner projects with advocacy groups.

Faunalytics

RCI works to create a world where every caregiver is seen, heard, and supported.

The Rosalynn Carter Institute For Caregivers drives transformative systems change to improve the strength, health, and resilience of family caregivers. People of all identities provide care to their family members, **but the experience falls disproportionately on women and girls**, with serious effects on their mental, physical, and economic health.

- 3 out of 5 caregivers in the US are women, and a significant number are women over 50.
- Caregiving disproportionately impacts women’s health. Female caregivers report higher levels of stress at every age, and also report that their health is negatively impacted. 
- More than half of all women caregivers in the US feel they did not have a choice in taking on their role.

RCI advances collaborative solutions rooted in evidence, driven by caregivers, and focused on achieving sustained impact. Together, we can work to change this experience and create a better world for family caregivers. Give today and help us create a world where every caregiver is seen, heard, and supported.

Source List:

1. AARP/NAC caregiving in the US (2020)
2. CDC Healthy Aging Data (2021) 
3. Gender Differences in Family Caregiving. BMC Health Services Research. Volume 24; Article number: 730 (2024) 
4. AARP/NAC caregiving in the US (2020)

Rosalynn Carter Institute for Caregivers

Committed to stamping out muscular dystrophy

Strongest Hearts is so excited to have you here.  We founded Strongest Hearts in 2022 after our son’s diagnosis with Becker’s Muscular Dystrophy.  BMD is an incredibly serious disease that affects the muscle systems of young boys and men.  Like the more common and more severe Duchenne’s, it is progressive and life threatening.

Strongest Hearts intends to end that threat.  Our non-profit is designed to exclusively work to find a cure or treatment, educate and advocate for this deadly disease.  DMD is the number one killer for adolescents in the US and we search to find a solution that will help over 90% of the DMD and BMD community.  

Like so many people and families, we have felt fear, anxiety and hopelessness and have received massively conflicting data from doctors and websites.  It is time to stop that cycle and move towards a day when we can say that a diagnosis of any muscular dystrophy, while unsettling, is no longer a tragedy.  We truly believe that we have the people, the skill and the technology to end this scourge once and for all.  

Join us in our fight.  Many Hearts, One Mission

Strongest Hearts Foundationis a project of Players Philanthropy Fund a Maryland charitable trust recognized by IRS as a tax-exempt public charity under Section 501(c)(3) of the Internal Revenue Code (Federal Tax ID: 27-6601178). Contributions to Strongest Hearts Foundationqualify as tax-deductible to the fullest extent of the law. 




Strongest Hearts Foundation

Neuromatch is democratizing science by creating opportunities in education, networking, and scientific communication. 

Neuromatch enables more people to participate in scientific research by overcoming barriers in the form of education, social networks, and accessibility of science communication. 

Specifically, we find innovative new ways to allow collaborative access in these areas by enabling groups of scientists to work together to make these platforms as public goods that can scale up to be used by many. 

Our Academy provides live instruction, open source education that is contributed to by hundreds of researchers to provide always affordable education to people around the world. We are active in 15 different countries and teach undergraduate and PhD level science in 20 different languages. 

Our Community program creates online-first scientific conferences and community events that focus on human interaction, allowing us to leverage the equitable nature of online work without significant sacrifices in the networking and connection aspect of these events. 

The NMDA program provides researchers with real on the job experience in internships, job matching, and career guidance. 

Our large buy in to these communities we serve provides us the ability to conquer problems in science dependent on large network effects, such as issues in academic publishing, job matching, and large research collaborations.

Neuromatch

Krista's Legacy Foundation (KLF) extends Krista Roth’s impact by advancing the causes about which she was most passionate.

Krista's Legacy Foundation (KLF) extends the late Krista Roth’s impact (4/22/99 - 1/20/21) by advancing the causes about which she was most passionate - Rainforest Restoration, Clean Water and Education. As the result of a childhood dream, Krista's Rainforest Sanctuary project started in the Monteverde Cloud Forest of Costa Rica with funds raised on what would have been Krista's 22nd birthday on Earth Day (April 22) 2021. In honor of her desire to help solve the world's water crisis, KLF works in partnership with Can Do Kids International in Kenya. KLF also sponsors projects supporting the education of underprivileged kids with potential to make the world a better place.

Krista's Legacy Foundation

Myriad USA facilitates thoughtful, effective giving across borders.

Myriad USA provides donors with a simple and efficient platform to support nonprofit initiatives overseas, anywhere across the globe. Myriad USA brings together the expertise and networks of the King Baudouin Foundation United States (KBFUS) and Give2Asia, and builds on their shared history, their shared belief that local knowledge counts, and their shared objective of improving the lives of people around the world. 

Myriad USA

The world's-first funding vehicle to collectively grow our resources to support the long-term flourishing of humanity. 


Join this first-of-its-kind philanthropic fund designed for the long-term future. Our Patient Philanthropy Fund addresses a crucial gap: humans spend too little on protecting and benefiting our future generations. However, we can positively affect the lives of our descendants, and avoid major catastrophes that could destroy their future.
 
Contributions are invested for long-term gains, initially in a low-fee Global Stock Index Fund. When a critical time, need, or opportunity arises, we step in to make a grant. Taking a patient approach allows us to wait for a point in time when the highest-impact opportunities are available, which may be years, decades, or even centuries ahead.

### Our Approach to Grantmaking
We're not designed to be a frequent grantmaker; we are primarily an investment account until we reach an extraordinary time and opportunity. Until those moments arise, each year we will make small grants at less than 1% of the Fund's size to the best available opportunities we are able to find in that year. These small grants will build up our grant-making infrastructure and track record. Grant decisions will be made by a dedicated management committee, all with a strong network and expertise on how well-timed grant-making can safeguard the future.

### Frequently-Asked Questions
**Can charities apply for money from the Fund?**
The Funds do not generally accept applications from charities, and we request that charities do not send unsolicited applications for funding. If the Fund Managers choose to open up an application round, this will be publicized. 

### More Questions? 

To learn more about the Founders Pledge Patient Philanthropy Fund, please visit [www.founderspledge.com](https://www.founderspledge.com/funds/patient-philanthropy-fund) or email the Fund Managers at funds@founderspledge.com.

Founders Pledge: Patient Philanthropy Fund

Closegap is a 501(c)(3) non-profit technology company on a mission to improve the emotional and mental health of K-12 students.

Closegap is a nonprofit tech startup that’s created a free daily mental health check-in for K-12 students. Each day, students complete a developmentally appropriate and interactive check-in, which asks a series of questions about their emotions, energy level, physical needs and more. Students then have the option to request to speak with a trusted adult or choose from a library of self-guided, social-emotional learning activities on the digital platform. School staff receive alerts, a daily triaged list of their students, and data visualizations to spot trends over time. Founded on the idea that every kid needs at least one trusted adult and self-regulation skills to navigate tough circumstances, we’re working to transform the way kids are cared for and supported within schools. 

THE PROBLEM 
Closegap is addressing the youth mental health crisis, and schools’ inability to meet student mental and emotional health needs. Youth anxiety, depression and suicide have been on the rise for the past decade. In 2019, one in three high school students reported persistent feelings of sadness or hopelessness, an increase of 40% from 2009. The pandemic exacerbated the crisis. In 2020, there was a 30% increase in emergency room visits for mental health reasons for youth ages 12-17. Today, suicide is the second leading cause of death among 15-24 year olds. 

Schools are on the frontlines of this crisis, and represent an enormous opportunity to strengthen our mental health safety net—most students (and BIPOC students, disproportionately) receive mental health services at schools. Yet, schools are often understaffed and under-resourced. When something is wrong, we don’t have mechanisms in place to catch it. Nationally, there are over 415 students for every 1 school counselor, almost double the recommended ratio. School staff are largely unequipped to monitor the needs of all their students or intervene in real time; it’s unrealistic that they can check-in with each student, and implicit bias can cloud judgment. Additionally, not all students feel comfortable asking for help. For this reason, many students slip through the cracks. Schools desperately need a way to gauge the mental health needs of their students both in real-time (for immediate individual support) and over time (for systemic support) to adequately address the youth mental health crisis. 

THE SOLUTION 
Closegap equips schools with the technology and data to more effectively support the mental health of K-12 students. 

The check-in is developmentally appropriate and backed by research from mental health experts and leading institutions, enabling schools to ask the right questions early and often. It first asks students about their feelings, needs, and challenges. Then the more foundational questions. Are they eating enough? Sleeping well? Is everything okay in their peer group? At the end, students are given the opportunity to privately ask for help from an adult or choose from a library of self-guided, evidence-based social-emotional learning activities, such as box breathing, shaking out parts of their body and making a gratitude list. Students learn to label, understand and regulate their emotions, and are provided with a new, direct line to school staff to express their emotional needs; this is particularly important for students who may not feel comfortable walking to the counselor’s office.

Check-in data enables school staff to monitor and intervene on student needs in real time and at scale; they receive alerts, a daily triaged list of students, and data visualizations to spot trends over time.  Schools move from a disjointed, reactive approach when serious crises occur to a proactive approach to care. 


IMPACT
Schools using Closegap have prevented suicides and uncovered cases of self-harm, sexual assault, bullying and trouble at home that would have otherwise gone unnoticed. The check-in leverages technology to bolster the current support system in schools—meeting kids right where they are, fostering more genuine connection between school staff and students, and increasing empathy and understanding. We’ve served over 200,000 students across all 50 states, with over 5.8 million check-ins completed to date.

Read about one school counselor who was able to help prevent a student suicide using Closegap: https://www.closegap.org/closegap-saving-lives-the-story

“I open up my dashboard and see 14 kids marked as urgent. That’s 14 kids that I wouldn’t have known needed me. Closegap brought those kids to my office.”
— Melena, School Counselor

“Some kids fly under the radar, but with Closegap they have an opportunity to say something that they’re not saying to anyone else.”
— Katie, School Counselor

“When I submit my Closegap for the day, it makes me feel that someone is actually listening to me, or cares about how I might feel that day.”
— Jaylynn, student




Closegap

We search for the charities that save or improve lives the most per dollar.

Our goal is to produce the world's top research on where to give. Free, for everyone.

We recommend a small number of charities that do an incredible amount of good. 

If you would like to donate to our giving funds or individual top charities, please see our projects below. You can donate here or on the Unrestricted Fund page below to make an unrestricted gift to GiveWell to support the full spectrum of our grantmaking and underwrite our ability to continue doing what we do.

GiveWell

1067431123

1431630327

148788709

1675433849

1873740264

2310049938

2352003526

2551237796

2595251256

281961830

2883383521

2899462032

316638097

338811242

3705164611

3874769064

3934974605

4083678788

4124487947

4167807122

440668958

698107245

91415239

1287028958

2729980760

3440869557

671754822

87081813

1014384873

1112422858

153399038

2028390811

220342792

2266630408

2519810400

2539558839

2826465835

We are a nonprofit, so instead of charging fees we rely on the generosity of donors like you.